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Intracellular signaling in tumor and endothelial cells: The expected and, yet again, the unexpected.
Stoeltzing O, Meric-Bernstam F, Ellis LM. Stoeltzing O, et al. Cancer Cell. 2006 Aug;10(2):89-91. doi: 10.1016/j.ccr.2006.07.013. Cancer Cell. 2006. PMID: 16904605 Review.
The inhibition of tyrosine kinase receptor signalling in leiomyosarcoma cells using the small molecule kinase inhibitor PTK787/ZK222584Ā (VatalanibĀ®).
Gaumann AK, Drexler HC, Lang SA, Stoeltzing O, Diermeier-Daucher S, Buchdunger E, Wood J, Bold G, Breier G. Gaumann AK, et al. Among authors: stoeltzing o. Int J Oncol. 2014 Dec;45(6):2267-77. doi: 10.3892/ijo.2014.2683. Epub 2014 Sep 29. Int J Oncol. 2014. PMID: 25340839 Free PMC article.
Oncogenic MST1R activity in pancreatic and gastric cancer represents a valid target of HSP90 inhibitors.
Moser C, Lang SA, Hackl C, Zhang H, Lundgren K, Hong V, McKenzie A, Weber B, Park JS, Schlitt HJ, Geissler EK, Jung YD, Stoeltzing O. Moser C, et al. Among authors: stoeltzing o. Anticancer Res. 2012 Feb;32(2):427-37. Anticancer Res. 2012. PMID: 22287729
Implication of heat shock protein 90 (HSP90) in tumor angiogenesis: a molecular target for anti-angiogenic therapy?
Staufer K, Stoeltzing O. Staufer K, et al. Among authors: stoeltzing o. Curr Cancer Drug Targets. 2010 Dec;10(8):890-7. doi: 10.2174/156800910793357934. Curr Cancer Drug Targets. 2010. PMID: 20718699 Review.
Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition.
Hackl C, Lang SA, Moser C, Mori A, Fichtner-Feigl S, Hellerbrand C, Dietmeier W, Schlitt HJ, Geissler EK, Stoeltzing O. Hackl C, et al. Among authors: stoeltzing o. BMC Cancer. 2010 Dec 3;10:668. doi: 10.1186/1471-2407-10-668. BMC Cancer. 2010. PMID: 21129190 Free PMC article.
Effect of heat-shock protein-90 (HSP90) inhibition on human hepatocytes and on liver regeneration in experimental models.
Hackl C, Mori A, Moser C, Lang SA, Dayoub R, Weiss TS, Schlitt HJ, Geissler EK, Hellerbrand C, Stoeltzing O. Hackl C, et al. Among authors: stoeltzing o. Surgery. 2010 May;147(5):704-12. doi: 10.1016/j.surg.2009.10.061. Epub 2009 Dec 16. Surgery. 2010. PMID: 20015528
STAT5b as molecular target in pancreatic cancer--inhibition of tumor growth, angiogenesis, and metastases.
Moser C, Ruemmele P, Gehmert S, Schenk H, Kreutz MP, Mycielska ME, Hackl C, Kroemer A, Schnitzbauer AA, Stoeltzing O, Schlitt HJ, Geissler EK, Lang SA. Moser C, et al. Among authors: stoeltzing o. Neoplasia. 2012 Oct;14(10):915-25. doi: 10.1593/neo.12878. Neoplasia. 2012. PMID: 23097626 Free PMC article.
Targeting HSP90 by the novel inhibitor NVP-AUY922 reduces growth and angiogenesis of pancreatic cancer.
Moser C, Lang SA, Hackl C, Wagner C, Scheiffert E, Schlitt HJ, Geissler EK, Stoeltzing O. Moser C, et al. Among authors: stoeltzing o. Anticancer Res. 2012 Jul;32(7):2551-61. Anticancer Res. 2012. PMID: 22753713
Targeting FGFR/PDGFR/VEGFR impairs tumor growth, angiogenesis, and metastasis by effects on tumor cells, endothelial cells, and pericytes in pancreatic cancer.
Taeger J, Moser C, Hellerbrand C, Mycielska ME, Glockzin G, Schlitt HJ, Geissler EK, Stoeltzing O, Lang SA. Taeger J, et al. Among authors: stoeltzing o. Mol Cancer Ther. 2011 Nov;10(11):2157-67. doi: 10.1158/1535-7163.MCT-11-0312. Epub 2011 Sep 1. Mol Cancer Ther. 2011. PMID: 21885862 Free article.
Implication of RICTOR in the mTOR inhibitor-mediated induction of insulin-like growth factor-I receptor (IGF-IR) and human epidermal growth factor receptor-2 (Her2) expression in gastrointestinal cancer cells.
Lang SA, Hackl C, Moser C, Fichtner-Feigl S, Koehl GE, Schlitt HJ, Geissler EK, Stoeltzing O. Lang SA, et al. Among authors: stoeltzing o. Biochim Biophys Acta. 2010 Apr;1803(4):435-42. doi: 10.1016/j.bbamcr.2010.01.009. Epub 2010 Jan 28. Biochim Biophys Acta. 2010. PMID: 20116405
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