Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

My NCBI Filters
Text availability
Article attribute
Article type
Publication date

Search Results

785 results
Filters applied: . Clear all Results are displayed in a computed author sort order. Results by year timeline is unavailable
Page 1
Effects of a dominant interfering mutant of FADD on signal transduction in activated T cells.
Newton K, Kurts C, Harris AW, Strasser A. Newton K, et al. Among authors: strasser a. Curr Biol. 2001 Feb 20;11(4):273-6. doi: 10.1016/s0960-9822(01)00067-7. Curr Biol. 2001. PMID: 11250157
Using transgenic mice expressing a dominant-negative mutant of FADD (FADD-DN), we show that functional FADD is required for T cells to proliferate in response to antigens in vivo as well as to mitogens in culture. The costimulation of wild-type and FADD-DN T cells with mit …
Using transgenic mice expressing a dominant-negative mutant of FADD (FADD-DN), we show that functional FADD is required for T cells t …
The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis.
Alvarez-Diaz S, Dillon CP, Lalaoui N, Tanzer MC, Rodriguez DA, Lin A, Lebois M, Hakem R, Josefsson EC, O'Reilly LA, Silke J, Alexander WS, Green DR, Strasser A. Alvarez-Diaz S, et al. Among authors: strasser a. Immunity. 2016 Sep 20;45(3):513-526. doi: 10.1016/j.immuni.2016.07.016. Epub 2016 Aug 11. Immunity. 2016. PMID: 27523270 Free PMC article.
The kinases RIPK1 and RIPK3 and the pseudo-kinase MLKL have been identified as key regulators of the necroptotic cell death pathway, although a role for MLKL within the whole animal has not yet been established. ...
The kinases RIPK1 and RIPK3 and the pseudo-kinase MLKL have been identified as key regulators of the necroptotic cell death pathway, althoug …
Role of Bim and other Bcl-2 family members in autoimmune and degenerative diseases.
Hughes P, Bouillet P, Strasser A. Hughes P, et al. Among authors: strasser a. Curr Dir Autoimmun. 2006;9:74-94. doi: 10.1159/000090773. Curr Dir Autoimmun. 2006. PMID: 16394656 Review.
Abnormalities in Bim expression and the thymic deletion of auto-reactive lymphocytes have also been implicated as a component of the complex, polygenic predisposition to autoimmune diabetes seen in NOD mice. ...
Abnormalities in Bim expression and the thymic deletion of auto-reactive lymphocytes have also been implicated as a component of the …
Role of proapoptotic BH3-only proteins in Listeria monocytogenes infection.
Margaroli C, Oberle S, Lavanchy C, Scherer S, Rosa M, Strasser A, Pellegrini M, Zehn D, Acha-Orbea H, Ehirchiou D. Margaroli C, et al. Among authors: strasser a. Eur J Immunol. 2016 Jun;46(6):1427-37. doi: 10.1002/eji.201545857. Eur J Immunol. 2016. PMID: 27064265
The ability of pathogens to influence host cell survival is a crucial virulence factor. Listeria monocytogenes (Lm) infection is known to be associated with severe apoptosis of hepatocytes and spleen cells. ...Our data show a novel pathway of infection-induced apopt …
The ability of pathogens to influence host cell survival is a crucial virulence factor. Listeria monocytogenes (Lm) infection is know …
XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation.
Yabal M, Müller N, Adler H, Knies N, Groß CJ, Damgaard RB, Kanegane H, Ringelhan M, Kaufmann T, Heikenwälder M, Strasser A, Groß O, Ruland J, Peschel C, Gyrd-Hansen M, Jost PJ. Yabal M, et al. Among authors: strasser a. Cell Rep. 2014 Jun 26;7(6):1796-808. doi: 10.1016/j.celrep.2014.05.008. Epub 2014 May 29. Cell Rep. 2014. PMID: 24882010
X-linked inhibitor of apoptosis protein (XIAP) has been identified as a potent regulator of innate immune responses, and loss-of-function mutations in XIAP cause the development of the X-linked lymphoproliferative syndrome type 2 (XLP-2) in humans. ...
X-linked inhibitor of apoptosis protein (XIAP) has been identified as a potent regulator of innate immune responses, and loss-of-func …
Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim.
Kaufmann T, Jost PJ, Pellegrini M, Puthalakath H, Gugasyan R, Gerondakis S, Cretney E, Smyth MJ, Silke J, Hakem R, Bouillet P, Mak TW, Dixit VM, Strasser A. Kaufmann T, et al. Among authors: strasser a. Immunity. 2009 Jan 16;30(1):56-66. doi: 10.1016/j.immuni.2008.10.017. Immunity. 2009. PMID: 19119023 Free PMC article.
Apoptotic death of hepatocytes, a contributor to many chronic and acute liver diseases, can be a consequence of overactivation of the immune system and is often mediated by TNFalpha. ...Loss of Bid, the proapoptotic BH3-only protein activated by caspase-8 and essent …
Apoptotic death of hepatocytes, a contributor to many chronic and acute liver diseases, can be a consequence of overactivation …
Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation.
Jabbour AM, Daunt CP, Green BD, Vogel S, Gordon L, Lee RS, Silke N, Pearson RB, Vandenberg CJ, Kelly PN, Nutt SL, Strasser A, Borner C, Ekert PG. Jabbour AM, et al. Among authors: strasser a. Blood. 2010 Jan 14;115(2):344-52. doi: 10.1182/blood-2009-07-230730. Epub 2009 Nov 17. Blood. 2010. PMID: 19965665 Free PMC article.
A survival advantage was also observed in untransformed p53(-/-) hematopoietic progenitor cells cultured in the presence or absence of cytokines. ...
A survival advantage was also observed in untransformed p53(-/-) hematopoietic progenitor cells cultured in the presence or absence o
The histone deacetylase inhibitors LAQ824 and LBH589 do not require death receptor signaling or a functional apoptosome to mediate tumor cell death or therapeutic efficacy.
Ellis L, Bots M, Lindemann RK, Bolden JE, Newbold A, Cluse LA, Scott CL, Strasser A, Atadja P, Lowe SW, Johnstone RW. Ellis L, et al. Among authors: strasser a. Blood. 2009 Jul 9;114(2):380-93. doi: 10.1182/blood-2008-10-182758. Epub 2009 Apr 21. Blood. 2009. PMID: 19383971 Free PMC article.
Emu-myc lymphomas lacking a functional apoptosome displayed morphologic and biochemical features of autophagy after treatment with LAQ824 and LBH589, indicating that, in the absence of a complete intrinsic apoptosis pathway involving apoptosome formation, these HDAC …
Emu-myc lymphomas lacking a functional apoptosome displayed morphologic and biochemical features of autophagy after treatment with LA …
Loss of the proapoptotic BH3-only protein BCL-2 modifying factor prolongs the fertile life span in female mice.
Liew SH, Vaithiyanathan K, Cook M, Bouillet P, Scott CL, Kerr JB, Strasser A, Findlay JK, Hutt KJ. Liew SH, et al. Among authors: strasser a. Biol Reprod. 2014 Apr 10;90(4):77. doi: 10.1095/biolreprod.113.116947. Print 2014 Apr. Biol Reprod. 2014. PMID: 24571986
Cell death, both during ovarian development in the embryo and in the postnatal ovary, plays a critical role in determining how many primordial follicles are established and maintained within the ovary. ...Bmf(-/-) females were fertile and produced the same number pups/litt …
Cell death, both during ovarian development in the embryo and in the postnatal ovary, plays a critical role in determining how many p …
The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells.
Bauer A, Villunger A, Labi V, Fischer SF, Strasser A, Wagner H, Schmid RM, Häcker G. Bauer A, et al. Among authors: strasser a. Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):10979-84. doi: 10.1073/pnas.0603625103. Epub 2006 Jul 10. Proc Natl Acad Sci U S A. 2006. PMID: 16832056 Free PMC article.
Our data define interrelations and a Bim-independent pathway to activated T cell death....
Our data define interrelations and a Bim-independent pathway to activated T cell death....
785 results
Jump to page
Feedback