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2003 3
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77 results

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Page 1
A broadly-neutralizing antibody against Orthoebolavirus glycoprotein that potentiates the breadth and neutralization of other antibodies.
Donnellan FR, Rayaprolu V, Rijal P, O'Dowd V, Parvate A, Callaway H, Hariharan C, Parekh D, Hui S, Shaffer KCL, Avalos RD, Hastie KM, Schimanski L, Müller-Kräuter H, Strecker T, Balaram A, Halfmann P, Saphire EO, Lightwood DJ, Townsend AR, Draper SJ. Donnellan FR, et al. Among authors: strecker t. Npj Viruses. 2026 May 7. doi: 10.1038/s44298-026-00192-7. Online ahead of print. Npj Viruses. 2026. PMID: 42098405 Free article.
Monoclonal antibodies (mAbs) against the virus glycoprotein (GP) are the only class of therapeutic approved for treatment of EVD caused by Orthoebolavirus zairense (Ebola virus, EBOV). ...
Monoclonal antibodies (mAbs) against the virus glycoprotein (GP) are the only class of therapeutic approved for treatment of EVD caus …
Serosurveillance Identifies an Endemic Hotspot of Lassa Fever in Faranah, Upper Guinea.
Mariën J, Nuismer SL, Magassouba N, Soropogui B, Günther S, Becker-Ziaja B, Gabriel M, Müller-Kräuter H, Strecker T, Saez AM, Borchert M, Fichet-Calvet E. Mariën J, et al. Among authors: strecker t. J Infect Dis. 2025 Nov 14;232(5):e830-e838. doi: 10.1093/infdis/jiaf308. J Infect Dis. 2025. PMID: 40509999 Free PMC article.
BACKGROUND: Lassa fever, caused by Lassa virus (LASV), is a rodent-borne disease endemic to West Africa. Despite growing interest from the global health community, the overall disease burden remains poorly understood due to persistent underreporting and inadequate diagnost …
BACKGROUND: Lassa fever, caused by Lassa virus (LASV), is a rodent-borne disease endemic to West Africa. Despite growing interest fro …
Lassa Virus Infection of Primary Human Airway Epithelial Cells.
Müller-Kräuter H, Fehling SK, Sauerhering L, Ehlert B, Koepke J, Schilling J, Matrosovich M, Maisner A, Strecker T. Müller-Kräuter H, et al. Among authors: strecker t. Viruses. 2025 Apr 22;17(5):592. doi: 10.3390/v17050592. Viruses. 2025. PMID: 40431605 Free PMC article.
Lassa mammarenavirus (LASV), a member of the family Arenaviridae, is a highly pathogenic virus capable of causing severe systemic infections in humans. The primary host reservoir is the Natal multimammate mouse (Mastomys natalensis), with human infections typically occurri …
Lassa mammarenavirus (LASV), a member of the family Arenaviridae, is a highly pathogenic virus capable of causing severe systemic inf …
rVSV-ZEBOV vaccination in people with pre-existing immunity to Ebolavirus: an open-label safety and immunogenicity study in Guinean communities affected by Ebola virus disease (l'essai proches).
Watson CH, Gsell PS, Hall Y, Camacho A, Riveros X, Enwere G, Vicari A, Nadlaou SD, Toure A, Sani IM, Diallo A, Kolie C, Duraffour S, Ifono K, Maomou A, Dore K, Djidonou HA, Bagayoko A, Damey PP, Camara MN, Diallo FB, Oumar FT, Toure K, Diaby ML, Sylla L, Conde D, Kaba IL, Tipton T, Eggo RM, Marks M, Roberts CH, Strecker T, Günther S, Keita S, Edmunds WJ, Carroll MW, Henao-Restrepo AM. Watson CH, et al. Among authors: strecker t. BMC Med. 2024 Nov 7;22(1):523. doi: 10.1186/s12916-024-03726-z. BMC Med. 2024. PMID: 39511527 Free PMC article.
Therefore, we assessed the impact pre-existing immunity had on post-vaccination IgG titre, virus neutralisation, and reactogenicity following vaccination. METHODS: In this prospective cohort study, 2115 consenting close contacts ("proches") of EVD survivors were recruited. …
Therefore, we assessed the impact pre-existing immunity had on post-vaccination IgG titre, virus neutralisation, and reactogenicity f …
Distinct negative-sense RNA viruses induce a common set of transcripts encoding proteins forming an extensive network.
Hofmann N, Bartkuhn M, Becker S, Biedenkopf N, Böttcher-Friebertshäuser E, Brinkrolf K, Dietzel E, Fehling SK, Goesmann A, Heindl MR, Hoffmann S, Karl N, Maisner A, Mostafa A, Kornecki L, Müller-Kräuter H, Müller-Ruttloff C, Nist A, Pleschka S, Sauerhering L, Stiewe T, Strecker T, Wilhelm J, Wuerth JD, Ziebuhr J, Weber F, Schmitz ML. Hofmann N, et al. Among authors: strecker t. J Virol. 2024 Oct 22;98(10):e0093524. doi: 10.1128/jvi.00935-24. Epub 2024 Sep 16. J Virol. 2024. PMID: 39283124 Free PMC article.
A newly developed open access web application allows downloads and visualizations of all gene expression comparisons for individual viruses over time or between several viruses. Most of the genes included in the core set of commonly differentially expressed genes (D …
A newly developed open access web application allows downloads and visualizations of all gene expression comparisons for individual virus …
Defining bottlenecks and opportunities for Lassa virus neutralization by structural profiling of vaccine-induced polyclonal antibody responses.
Brouwer PJM, Perrett HR, Beaumont T, Nijhuis H, Kruijer S, Burger JA, Bontjer I, Lee WH, Ferguson JA, Schauflinger M, Müller-Kräuter H, Sanders RW, Strecker T, van Gils MJ, Ward AB. Brouwer PJM, et al. Among authors: strecker t. Cell Rep. 2024 Sep 24;43(9):114708. doi: 10.1016/j.celrep.2024.114708. Epub 2024 Sep 6. Cell Rep. 2024. PMID: 39243373 Free PMC article.
The isolation of protective neutralizing antibodies against the Lassa virus glycoprotein complex (GPC) justifies the development of vaccines that can elicit strong neutralizing antibody responses. ...By applying this method to rabbits vaccinated with a recombinant GPC vacc …
The isolation of protective neutralizing antibodies against the Lassa virus glycoprotein complex (GPC) justifies the development of v …
Hexestrol, an estrogen receptor agonist, inhibits Lassa virus entry.
Zhang Z, Takenaga T, Fehling SK, Igarashi M, Hirokawa T, Muramoto Y, Yamauchi K, Onishi C, Nakano M, Urata S, Groseth A, Strecker T, Noda T. Zhang Z, et al. Among authors: strecker t. J Virol. 2024 Jul 23;98(7):e0071424. doi: 10.1128/jvi.00714-24. Epub 2024 May 29. J Virol. 2024. PMID: 38809021 Free PMC article.
Lassa virus (LASV) is the causative agent of human Lassa fever which in severe cases manifests as hemorrhagic fever leading to thousands of deaths annually. ...Through the generation of a HES-resistant virus, we found that phenylalanine at position 446 (F446) within …
Lassa virus (LASV) is the causative agent of human Lassa fever which in severe cases manifests as hemorrhagic fever leading to thousa …
A broadly-neutralizing antibody against Ebolavirus glycoprotein that potentiates the breadth and neutralization potency of other antibodies.
Donnellan FR, Rayaprolu V, Rijal P, O'Dowd V, Parvate A, Callaway H, Hariharan C, Parekh D, Hui S, Shaffer K, Avalos RD, Hastie K, Schimanski L, Müller-Kräuter H, Strecker T, Balaram A, Halfmann P, Saphire EO, Lightwood DJ, Townsend AR, Draper SJ. Donnellan FR, et al. Among authors: strecker t. bioRxiv [Preprint]. 2024 Jun 25:2024.06.21.600001. doi: 10.1101/2024.06.21.600001. bioRxiv. 2024. Update in: Npj Viruses. 2026 May 7. doi: 10.1038/s44298-026-00192-7. PMID: 38979279 Free PMC article. Updated. Preprint.
Monoclonal antibodies (mAbs) against the virus glycoprotein (GP) are the only class of therapeutic approved for treatment of EVD caused by Zaire ebolavirus (EBOV). ...
Monoclonal antibodies (mAbs) against the virus glycoprotein (GP) are the only class of therapeutic approved for treatment of EVD caus …
Serological evidence of zoonotic filovirus exposure among bushmeat hunters in Guinea.
Akoi Boré J, Timothy JWS, Tipton T, Kekoura I, Hall Y, Hood G, Longet S, Fornace K, Lucien MS, Fehling SK, Koivogui BK, Coggins SA, Laing ED, Broder CC, Magassouba NF, Strecker T, Rossman J, Konde K, Carroll MW. Akoi Boré J, et al. Among authors: strecker t. Nat Commun. 2024 May 16;15(1):4171. doi: 10.1038/s41467-024-48587-5. Nat Commun. 2024. PMID: 38755147 Free PMC article.
Human Ebola virus (EBOV) outbreaks caused by persistent EBOV infection raises questions on the role of zoonotic spillover in filovirus epidemiology. ...
Human Ebola virus (EBOV) outbreaks caused by persistent EBOV infection raises questions on the role of zoonotic spillover in filoviru …
Defining bottlenecks and opportunities for Lassa virus neutralization by structural profiling of vaccine-induced polyclonal antibody responses.
Brouwer PJM, Perrett HR, Beaumont T, Nijhuis H, Kruijer S, Burger JA, Lee WH, Müller-Kraüter H, Sanders RW, Strecker T, van Gils MJ, Ward AB. Brouwer PJM, et al. Among authors: strecker t. bioRxiv [Preprint]. 2023 Dec 23:2023.12.21.572918. doi: 10.1101/2023.12.21.572918. bioRxiv. 2023. Update in: Cell Rep. 2024 Sep 24;43(9):114708. doi: 10.1016/j.celrep.2024.114708. PMID: 38187682 Free PMC article. Updated. Preprint.
The isolation of potent and protective neutralizing antibodies against the Lassa virus glycoprotein complex (GPC) justifies the development of vaccines that can elicit strong neutralizing antibody responses. ...By applying this method to rabbits vaccinated with a recombina …
The isolation of potent and protective neutralizing antibodies against the Lassa virus glycoprotein complex (GPC) justifies the devel …
77 results