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Prosubstrates of CYP3A4, the major human hepatic cytochrome P450: transformation into substrates by other P450 isoforms.
Stresser DM, Kupfer D. Stresser DM, et al. Biochem Pharmacol. 1998 Jun 1;55(11):1861-71. doi: 10.1016/s0006-2952(98)00060-4. Biochem Pharmacol. 1998. PMID: 9714305
CYP3A4 does not catalyze the O-demethylation or hydroxylation of methoxychlor, but does hydroxylate mono-OH-M (ortho to the phenolic hydroxyl) (Stresser DM and Kupfer D, Biochemistry 36: 2203-2210, 1997). A combination of reconstituted CYP2C19 and 3A4 in the same ve …
CYP3A4 does not catalyze the O-demethylation or hydroxylation of methoxychlor, but does hydroxylate mono-OH-M (ortho to the phenolic hydroxy …
In vitro and pharmacophore insights into CYP3A enzymes.
Ekins S, Stresser DM, Williams JA. Ekins S, et al. Among authors: stresser dm. Trends Pharmacol Sci. 2003 Apr;24(4):161-6. doi: 10.1016/s0165-6147(03)00049-x. Trends Pharmacol Sci. 2003. PMID: 12707001 Review.
In Vitro Drug Metabolism Using Liver Microsomes.
Knights KM, Stresser DM, Miners JO, Crespi CL. Knights KM, et al. Among authors: stresser dm. Curr Protoc Pharmacol. 2016 Sep 16;74:7.8.1-7.8.24. doi: 10.1002/cpph.9. Curr Protoc Pharmacol. 2016. PMID: 27636111
45 results