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Prosubstrates of CYP3A4, the major human hepatic cytochrome P450: transformation into substrates by other P450 isoforms.
Stresser DM, Kupfer D. Stresser DM, et al. Biochem Pharmacol. 1998 Jun 1;55(11):1861-71. doi: 10.1016/s0006-2952(98)00060-4. Biochem Pharmacol. 1998. PMID: 9714305
CYP3A4 does not catalyze the O-demethylation or hydroxylation of methoxychlor, but does hydroxylate mono-OH-M (ortho to the phenolic hydroxyl) (Stresser DM and Kupfer D, Biochemistry 36: 2203-2210, 1997). A combination of reconstituted CYP2C19 and 3A4 in the same ve …
CYP3A4 does not catalyze the O-demethylation or hydroxylation of methoxychlor, but does hydroxylate mono-OH-M (ortho to the phenolic hydroxy …
45 results