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Inhibitors of the protease from human immunodeficiency virus: design and modeling of a compound containing a dihydroxyethylene isostere insert with high binding affinity and effective antiviral activity.
Thaisrivongs S, Tomasselli AG, Moon JB, Hui J, McQuade TJ, Turner SR, Strohbach JW, Howe WJ, Tarpley WG, Heinrikson RL. Thaisrivongs S, et al. Among authors: strohbach jw. J Med Chem. 1991 Aug;34(8):2344-56. doi: 10.1021/jm00112a005. J Med Chem. 1991. PMID: 1875334
Inhibitors of the protease from human immunodeficiency virus: synthesis, enzyme inhibition, and antiviral activity of a series of compounds containing the dihydroxyethylene transition-state isostere.
Thaisrivongs S, Turner SR, Strohbach JW, TenBrink RE, Tarpley WG, McQuade TJ, Heinrikson RL, Tomasselli AG, Hui JO, Howe WJ. Thaisrivongs S, et al. Among authors: strohbach jw. J Med Chem. 1993 Apr 16;36(8):941-52. doi: 10.1021/jm00060a001. J Med Chem. 1993. PMID: 8478908
Structure-based design of HIV protease inhibitors: sulfonamide-containing 5,6-dihydro-4-hydroxy-2-pyrones as non-peptidic inhibitors.
Thaisrivongs S, Skulnick HI, Turner SR, Strohbach JW, Tommasi RA, Johnson PD, Aristoff PA, Judge TM, Gammill RB, Morris JK, Romines KR, Chrusciel RA, Hinshaw RR, Chong KT, Tarpley WG, Poppe SM, Slade DE, Lynn JC, Horng MM, Tomich PK, Seest EP, Dolak LA, Howe WJ, Howard GM, Watenpaugh KD, et al. Thaisrivongs S, et al. Among authors: strohbach jw. J Med Chem. 1996 Oct 25;39(22):4349-53. doi: 10.1021/jm960541s. J Med Chem. 1996. PMID: 8893827 No abstract available.
Structure-based design of HIV protease inhibitors: 5,6-dihydro-4-hydroxy-2-pyrones as effective, nonpeptidic inhibitors.
Thaisrivongs S, Romero DL, Tommasi RA, Janakiraman MN, Strohbach JW, Turner SR, Biles C, Morge RR, Johnson PD, Aristoff PA, Tomich PK, Lynn JC, Horng MM, Chong KT, Hinshaw RR, Howe WJ, Finzel BC, Watenpaugh KD. Thaisrivongs S, et al. Among authors: strohbach jw. J Med Chem. 1996 Nov 8;39(23):4630-42. doi: 10.1021/jm960228q. J Med Chem. 1996. PMID: 8917652
Tipranavir (PNU-140690): a potent, orally bioavailable nonpeptidic HIV protease inhibitor of the 5,6-dihydro-4-hydroxy-2-pyrone sulfonamide class.
Turner SR, Strohbach JW, Tommasi RA, Aristoff PA, Johnson PD, Skulnick HI, Dolak LA, Seest EP, Tomich PK, Bohanon MJ, Horng MM, Lynn JC, Chong KT, Hinshaw RR, Watenpaugh KD, Janakiraman MN, Thaisrivongs S. Turner SR, et al. Among authors: strohbach jw. J Med Chem. 1998 Aug 27;41(18):3467-76. doi: 10.1021/jm9802158. J Med Chem. 1998. PMID: 9719600
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