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Somatostatin inhibits insulin and glucagon secretion via two receptors subtypes: an in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice.
Strowski MZ, Parmar RM, Blake AD, Schaeffer JM. Strowski MZ, et al. Endocrinology. 2000 Jan;141(1):111-7. doi: 10.1210/endo.141.1.7263. Endocrinology. 2000. PMID: 10614629
Somatostatin receptor subtypes 2 and 5 inhibit corticotropin-releasing hormone-stimulated adrenocorticotropin secretion from AtT-20 cells.
Strowski MZ, Dashkevicz MP, Parmar RM, Wilkinson H, Kohler M, Schaeffer JM, Blake AD. Strowski MZ, et al. Neuroendocrinology. 2002 Jun;75(6):339-46. doi: 10.1159/000059430. Neuroendocrinology. 2002. PMID: 12065886
Somatostatin receptor subtype 5 regulates insulin secretion and glucose homeostasis.
Strowski MZ, Kohler M, Chen HY, Trumbauer ME, Li Z, Szalkowski D, Gopal-Truter S, Fisher JK, Schaeffer JM, Blake AD, Zhang BB, Wilkinson HA. Strowski MZ, et al. Mol Endocrinol. 2003 Jan;17(1):93-106. doi: 10.1210/me.2001-0035. Mol Endocrinol. 2003. PMID: 12511609
Somatostatin stimulates ductal bile absorption and inhibits ductal bile secretion in mice via SSTR2 on cholangiocytes.
Gong AY, Tietz PS, Muff MA, Splinter PL, Huebert RC, Strowski MZ, Chen XM, LaRusso NF. Gong AY, et al. Among authors: strowski mz. Am J Physiol Cell Physiol. 2003 May;284(5):C1205-14. doi: 10.1152/ajpcell.00313.2002. Am J Physiol Cell Physiol. 2003. PMID: 12676656
Small-molecule insulin mimetic reduces hyperglycemia and obesity in a nongenetic mouse model of type 2 diabetes.
Strowski MZ, Li Z, Szalkowski D, Shen X, Guan XM, Jüttner S, Moller DE, Zhang BB. Strowski MZ, et al. Endocrinology. 2004 Nov;145(11):5259-68. doi: 10.1210/en.2004-0610. Epub 2004 Aug 5. Endocrinology. 2004. PMID: 15297448
Hepatic glucagon receptor binding and glucose-lowering in vivo by peptidyl and non-peptidyl glucagon receptor antagonists.
Dallas-Yang Q, Shen X, Strowski M, Brady E, Saperstein R, Gibson RE, Szalkowski D, Qureshi SA, Candelore MR, Fenyk-Melody JE, Parmee ER, Zhang BB, Jiang G. Dallas-Yang Q, et al. Among authors: strowski m. Eur J Pharmacol. 2004 Oct 6;501(1-3):225-34. doi: 10.1016/j.ejphar.2004.08.023. Eur J Pharmacol. 2004. PMID: 15464082
Evidence that orexins A and B stimulate insulin secretion from rat pancreatic islets via both receptor subtypes.
Nowak KW, Strowski MZ, Switonska MM, Kaczmarek P, Singh V, Fabis M, Mackowiak P, Nowak M, Malendowicz LK. Nowak KW, et al. Among authors: strowski mz. Int J Mol Med. 2005 Jun;15(6):969-72. Int J Mol Med. 2005. PMID: 15870901
Antidiabetic activity of a highly potent and selective nonpeptide somatostatin receptor subtype-2 agonist.
Strowski MZ, Cashen DE, Birzin ET, Yang L, Singh V, Jacks TM, Nowak KW, Rohrer SP, Patchett AA, Smith RG, Schaeffer JM. Strowski MZ, et al. Endocrinology. 2006 Oct;147(10):4664-73. doi: 10.1210/en.2006-0274. Epub 2006 Jul 20. Endocrinology. 2006. PMID: 16857751
Characterization of somatostatin receptor subtype-specific regulation of insulin and glucagon secretion: an in vitro study on isolated human pancreatic islets.
Singh V, Brendel MD, Zacharias S, Mergler S, Jahr H, Wiedenmann B, Bretzel RG, Plöckinger U, Strowski MZ. Singh V, et al. Among authors: strowski mz. J Clin Endocrinol Metab. 2007 Feb;92(2):673-80. doi: 10.1210/jc.2006-1578. Epub 2006 Nov 14. J Clin Endocrinol Metab. 2007. PMID: 17105845
Somatostatin receptor subtype-2-deficient mice with diet-induced obesity have hyperglycemia, nonfasting hyperglucagonemia, and decreased hepatic glycogen deposition.
Singh V, Grötzinger C, Nowak KW, Zacharias S, Göncz E, Pless G, Sauer IM, Eichhorn I, Pfeiffer-Guglielmi B, Hamprecht B, Wiedenmann B, Plöckinger U, Strowski MZ. Singh V, et al. Among authors: strowski mz. Endocrinology. 2007 Aug;148(8):3887-99. doi: 10.1210/en.2006-1659. Epub 2007 May 24. Endocrinology. 2007. PMID: 17525126
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