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Structural basis of Focal Adhesion Kinase activation on lipid membranes.
Acebrón I, Righetto RD, Schoenherr C, de Buhr S, Redondo P, Culley J, Rodríguez CF, Daday C, Biyani N, Llorca O, Byron A, Chami M, Gräter F, Boskovic J, Frame MC, Stahlberg H, Lietha D. Acebrón I, et al. EMBO J. 2020 Oct 1;39(19):e104743. doi: 10.15252/embj.2020104743. Epub 2020 Aug 11. EMBO J. 2020. PMID: 32779739
Focal adhesion kinase (FAK) is a key component of the membrane proximal signaling layer in focal adhesion complexes, regulating important cellular processes, including cell migration, proliferation, and survival. In the cytosol, FAK adopts an
Focal adhesion kinase (FAK) is a key component of the membrane proximal signaling layer in focal adhesion
Molecular basis for autoinhibition of RIAM regulated by FAK in integrin activation.
Chang YC, Su W, Cho EA, Zhang H, Huang Q, Philips MR, Wu J. Chang YC, et al. Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3524-3529. doi: 10.1073/pnas.1818880116. Epub 2019 Feb 7. Proc Natl Acad Sci U S A. 2019. PMID: 30733287 Free PMC article.
This autoinhibitory configuration of RIAM can be released by phosphorylation at Tyr45 in the IN segment. Specific inhibitors of focal adhesion kinase (FAK) blocked phosphorylation of Tyr45, inhibited stimulated translocation of RIAM to the plasma membrane, an …
This autoinhibitory configuration of RIAM can be released by phosphorylation at Tyr45 in the IN segment. Specific inhibitors of focal
Structural basis for the autoinhibition of focal adhesion kinase.
Lietha D, Cai X, Ceccarelli DF, Li Y, Schaller MD, Eck MJ. Lietha D, et al. Cell. 2007 Jun 15;129(6):1177-87. doi: 10.1016/j.cell.2007.05.041. Cell. 2007. PMID: 17574028 Free PMC article.
Appropriate tyrosine kinase signaling depends on coordinated sequential coupling of protein-protein interactions with catalytic activation. Focal adhesion kinase (FAK) integrates signals from integrin and growth factor receptors to …
Appropriate tyrosine kinase signaling depends on coordinated sequential coupling of protein-protein interactions …
Structural Insights How PIP2 Imposes Preferred Binding Orientations of FAK at Lipid Membranes.
Herzog FA, Braun L, Schoen I, Vogel V. Herzog FA, et al. J Phys Chem B. 2017 Apr 20;121(15):3523-3535. doi: 10.1021/acs.jpcb.6b09349. Epub 2017 Feb 10. J Phys Chem B. 2017. PMID: 28124908
Focal adhesion kinase (FAK) is a multidomain protein (FERM-kinase-FAT) with important signaling functions in the regulation of cell-substrate adhesions. ...To elucidate the molecular basis of activation, we performed a systematic screenin
Focal adhesion kinase (FAK) is a multidomain protein (FERM-kinase-FAT) with important signaling functions