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Structural basis of Focal Adhesion Kinase activation on lipid membranes.
Acebrón I, Righetto RD, Schoenherr C, de Buhr S, Redondo P, Culley J, Rodríguez CF, Daday C, Biyani N, Llorca O, Byron A, Chami M, Gräter F, Boskovic J, Frame MC, Stahlberg H, Lietha D. Acebrón I, et al. EMBO J. 2020 Oct 1;39(19):e104743. doi: 10.15252/embj.2020104743. Epub 2020 Aug 11. EMBO J. 2020. PMID: 32779739 Free PMC article.
Focal adhesion kinase (FAK) is a key component of the membrane proximal signaling layer in focal adhesion complexes, regulating important cellular processes, including cell migration, proliferation, and survival. In the cytosol, FAK adopts an
Focal adhesion kinase (FAK) is a key component of the membrane proximal signaling layer in focal adhesion
Structural basis for the autoinhibition of focal adhesion kinase.
Lietha D, Cai X, Ceccarelli DF, Li Y, Schaller MD, Eck MJ. Lietha D, et al. Cell. 2007 Jun 15;129(6):1177-87. doi: 10.1016/j.cell.2007.05.041. Cell. 2007. PMID: 17574028 Free PMC article.
Focal adhesion kinase (FAK) integrates signals from integrin and growth factor receptors to regulate cellular responses including cell adhesion, migration, and survival. Here, we describe crystal structures representing both autoinhibited
Focal adhesion kinase (FAK) integrates signals from integrin and growth factor receptors to regulate cellular responses
Molecular basis for autoinhibition of RIAM regulated by FAK in integrin activation.
Chang YC, Su W, Cho EA, Zhang H, Huang Q, Philips MR, Wu J. Chang YC, et al. Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3524-3529. doi: 10.1073/pnas.1818880116. Epub 2019 Feb 7. Proc Natl Acad Sci U S A. 2019. PMID: 30733287 Free PMC article.
The RAS-association (RA) segment of the RA-PH module of RIAM interacts with GTP-bound RAP1 and phosphoinositol 4,5 bisphosphate but this interaction is inhibited by the N-terminal segment of RIAM. Here we report the structural basis for the autoinhibition of …
The RAS-association (RA) segment of the RA-PH module of RIAM interacts with GTP-bound RAP1 and phosphoinositol 4,5 bisphosphate but this int …
Structural Insights How PIP2 Imposes Preferred Binding Orientations of FAK at Lipid Membranes.
Herzog FA, Braun L, Schoen I, Vogel V. Herzog FA, et al. J Phys Chem B. 2017 Apr 20;121(15):3523-3535. doi: 10.1021/acs.jpcb.6b09349. Epub 2017 Feb 10. J Phys Chem B. 2017. PMID: 28124908
Focal adhesion kinase (FAK) is a multidomain protein (FERM-kinase-FAT) with important signaling functions in the regulation of cell-substrate adhesions. ...To elucidate the molecular basis of activation, we performed a systematic screening of bi
Focal adhesion kinase (FAK) is a multidomain protein (FERM-kinase-FAT) with important signaling functions in the