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Structural basis of DNA targeting by a transposon-encoded CRISPR-Cas system.
Halpin-Healy TS, Klompe SE, Sternberg SH, Fernández IS. Halpin-Healy TS, et al. Nature. 2020 Jan;577(7789):271-274. doi: 10.1038/s41586-019-1849-0. Epub 2019 Dec 18. Nature. 2020. PMID: 31853065
Type I CRISPR-Cas systems typically target foreign DNA for degradation via joint action of the ribonucleoprotein complex Cascade and the helicase-nuclease Cas3(4,5), but nuclease-deficient type I systems lacking Cas3 have been repurposed …
Type I CRISPR-Cas systems typically target foreign DNA for degradation via joint action of the ribonucleo …