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Mitofusin 2 tethers endoplasmic reticulum to mitochondria.
de Brito OM, Scorrano L. de Brito OM, et al. Nature. 2008 Dec 4;456(7222):605-10. doi: 10.1038/nature07534. Nature. 2008. PMID: 19052620
An in vitro assay as well as genetic and biochemical evidences support a model in which mitofusin 2 on the ER bridges the two organelles by engaging in homotypic and heterotypic complexes with mitofusin 1 or 2 on the surface of mitochondria. Thus, m …
An in vitro assay as well as genetic and biochemical evidences support a model in which mitofusin 2 on the ER bridges the two organel …
Structural basis of mitochondrial tethering by mitofusin complexes.
Koshiba T, Detmer SA, Kaiser JT, Chen H, McCaffery JM, Chan DC. Koshiba T, et al. Science. 2004 Aug 6;305(5685):858-62. doi: 10.1126/science.1099793. Science. 2004. PMID: 15297672
Vesicle fusion involves vesicle tethering, docking, and membrane merger. We show that mitofusin, an integral mitochondrial membrane protein, is required on adjacent mitochondria to mediate fusion, which indicates that mitofusin complexes …
Vesicle fusion involves vesicle tethering, docking, and membrane merger. We show that mitofusin, an integral mitochondrial …
Structural basis for GTP hydrolysis and conformational change of MFN1 in mediating membrane fusion.
Yan L, Qi Y, Huang X, Yu C, Lan L, Guo X, Rao Z, Hu J, Lou Z. Yan L, et al. Nat Struct Mol Biol. 2018 Mar;25(3):233-243. doi: 10.1038/s41594-018-0034-8. Epub 2018 Feb 26. Nat Struct Mol Biol. 2018. PMID: 29483649
Fusion of the outer mitochondrial membrane is mediated by the dynamin-like GTPase mitofusin (MFN). Here, we determined the structure of the minimal GTPase domain (MGD) of human MFN1 in complex with GDP-BeF(3)(-). ...Enzymatic analysis has confirmed tha …
Fusion of the outer mitochondrial membrane is mediated by the dynamin-like GTPase mitofusin (MFN). Here, we determined the …