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Structure of a ubiquitin E1-E2 complex: insights to E1-E2 thioester transfer.
Olsen SK, Lima CD. Olsen SK, et al. Mol Cell. 2013 Mar 7;49(5):884-96. doi: 10.1016/j.molcel.2013.01.013. Epub 2013 Feb 14. Mol Cell. 2013. PMID: 23416107 Free PMC article.
How the E1 and E2 active sites come together during thioester transfer and how Ub E1 interacts with diverse Ub E2s remains unclear. Here we present a crystal structure of a Ub E1-E2(Ubc4)/Ub/ATP.Mg complex that was stabilized by induction …
How the E1 and E2 active sites come together during thioester transfer and how Ub E1 interacts with diverse Ub E2s remains unc …
Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer.
Afsar M, Liu G, Jia L, Ruben EA, Nayak D, Sayyad Z, Bury PDS, Cano KE, Nayak A, Zhao XR, Shukla A, Sung P, Wasmuth EV, Gack MU, Olsen SK. Afsar M, et al. Nat Commun. 2023 Aug 8;14(1):4786. doi: 10.1038/s41467-023-39780-z. Nat Commun. 2023. PMID: 37553340 Free PMC article.
Despite its biological importance, the molecular basis by which Uba7 catalyzes ISG15 activation and transfer to UBE2L6 is unknown as there is no available structure of Uba7. Here, we present cryo-EM structures of human Uba7 in complex with UBE2L6, ISG1 …
Despite its biological importance, the molecular basis by which Uba7 catalyzes ISG15 activation and transfer to UBE2L6 is unknown as …
Chemical Tools for Probing the Ub/Ubl Conjugation Cascades.
Kochańczyk T, Fishman M, Lima CD. Kochańczyk T, et al. Chembiochem. 2025 Jan 2;26(1):e202400659. doi: 10.1002/cbic.202400659. Epub 2024 Nov 6. Chembiochem. 2025. PMID: 39313481 Free PMC article. Review.
Conjugation of ubiquitin (Ub) and structurally related ubiquitin-like proteins (Ubls), essential for many cellular processes, employs multi-step reactions orchestrated by specific E1, E2 and E3 enzymes. ...The E1-E2-E3 enzymatic ca …
Conjugation of ubiquitin (Ub) and structurally related ubiquitin-like proteins (Ubls), essential for many cellular proc …
NMR and X-RAY structures of human E2-like ubiquitin-fold modifier conjugating enzyme 1 (UFC1) reveal structural and functional conservation in the metazoan UFM1-UBA5-UFC1 ubiquination pathway.
Liu G, Forouhar F, Eletsky A, Atreya HS, Aramini JM, Xiao R, Huang YJ, Abashidze M, Seetharaman J, Liu J, Rost B, Acton T, Montelione GT, Hunt JF, Szyperski T. Liu G, et al. J Struct Funct Genomics. 2009 Apr;10(2):127-36. doi: 10.1007/s10969-008-9054-7. Epub 2008 Dec 20. J Struct Funct Genomics. 2009. PMID: 19101823 Free PMC article.
For cell regulation, E2-like ubiquitin-fold modifier conjugating enzyme 1 (Ufc1) is involved in the transfer of ubiquitin-fold modifier 1 (Ufm1), a ubiquitin like protein which is activated by E1-like enzyme Uba5, to various target proteins. ...The act …
For cell regulation, E2-like ubiquitin-fold modifier conjugating enzyme 1 (Ufc1) is involved in the transfer of ubiquitin