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Structure of the inner kinetochore CCAN complex assembled onto a centromeric nucleosome.
Yan K, Yang J, Zhang Z, McLaughlin SH, Chang L, Fasci D, Ehrenhofer-Murray AE, Heck AJR, Barford D. Yan K, et al. Nature. 2019 Oct;574(7777):278-282. doi: 10.1038/s41586-019-1609-1. Epub 2019 Oct 2. Nature. 2019. PMID: 31578520 Free PMC article.
In eukaryotes, accurate chromosome segregation in mitosis and meiosis maintains genome stability and prevents aneuploidy. Kinetochores are large protein complexes that, by assembling onto specialized Cenp-A nucleosomes(1,2), function to connect …
In eukaryotes, accurate chromosome segregation in mitosis and meiosis maintains genome stability and prevents aneuploidy. Kinetochores
Crystal structure of the Cenp-HIKHead-TW sub-module of the inner kinetochore CCAN complex.
Zhang Z, Bellini D, Barford D. Zhang Z, et al. Nucleic Acids Res. 2020 Nov 4;48(19):11172-11184. doi: 10.1093/nar/gkaa772. Nucleic Acids Res. 2020. PMID: 32976599 Free PMC article.
Kinetochores are large multi-subunit complexes that attach centromeric chromatin to microtubules of the mitotic spindle, enabling sister chromatid segregation in mitosis. The inner kinetochore constitutive centromere associated network (
Kinetochores are large multi-subunit complexes that attach centromeric chromatin to microtubules of the mitotic spindle
The CENP-T C-terminus is exclusively proximal to H3.1 and not to H3.2 or H3.3.
Abendroth C, Hofmeister A, Hake SB, Kamweru PK, Miess E, Dornblut C, Küffner I, Deng W, Leonhardt H, Orthaus S, Hoischen C, Diekmann S. Abendroth C, et al. Int J Mol Sci. 2015 Mar 12;16(3):5839-63. doi: 10.3390/ijms16035839. Int J Mol Sci. 2015. PMID: 25775162 Free PMC article.
The inner kinetochore proteins bind centromeres while most outer kinetochore proteins assemble at centromeres during mitosis, connecting the complex to microtubules. The centromere-kinetochore complex contains …
The inner kinetochore proteins bind centromeres while most outer kinetochore proteins assemble at cent