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Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis.
Scapin G, Dandey VP, Zhang Z, Prosise W, Hruza A, Kelly T, Mayhood T, Strickland C, Potter CS, Carragher B. Scapin G, et al. Nature. 2018 Apr 5;556(7699):122-125. doi: 10.1038/nature26153. Epub 2018 Feb 28. Nature. 2018. PMID: 29512653 Free PMC article.
Here we report single-particle cryo-electron microscopy reconstructions of the 1:2 (4.3 A) and 1:1 (7.4 A) complexes of the insulin receptor ECD dimer with insulin. ...The 7.4 A structure has only one similarly bound insulin …
Here we report single-particle cryo-electron microscopy reconstructions of the 1:2 (4.3 A) and 1:1 (7.4 A) complexes of …
Cryo-EM structure of orphan G protein-coupled receptor GPR21.
Wong TS, Gao W, Chen G, Qiu C, He G, Ye F, Wu Z, Zeng Z, Du Y. Wong TS, et al. MedComm (2020). 2023 Jan 25;4(1):e205. doi: 10.1002/mco2.205. eCollection 2023 Feb. MedComm (2020). 2023. PMID: 36721851 Free PMC article.
To gain further insights into the structural mechanisms of GPR21 activation, we employed cryo-electron microscopy (cryo-EM) and single-particle analysis to resolve the high-resolution structure of GPR21-Galphas complexes. .. …
To gain further insights into the structural mechanisms of GPR21 activation, we employed cryo-electron microscopy (cryo-EM …
Visualization of Ligand-Bound Ectodomain Assembly in the Full-Length Human IGF-1 Receptor by Cryo-EM Single-Particle Analysis.
Zhang X, Yu D, Sun J, Wu Y, Gong J, Li X, Liu L, Liu S, Liu J, Wu Y, Li D, Ma Y, Han X, Zhu Y, Wu Z, Wang Y, Ouyang Q, Wang T. Zhang X, et al. Structure. 2020 May 5;28(5):555-561.e4. doi: 10.1016/j.str.2020.03.007. Epub 2020 Apr 9. Structure. 2020. PMID: 32275863 Free article.
However, the complete structure of the receptor and the signal transduction mechanism remains unclear. Here, we report the cryo-EM structure of the ligand-bound ectodomain in the full-length human IGF-1R. We reconstructed the IGF-1R/insulin …
However, the complete structure of the receptor and the signal transduction mechanism remains unclear. Here, we report the …