Visualization of Ligand-Bound Ectodomain Assembly in the Full-Length Human IGF-1 Receptor by Cryo-EM Single-Particle Analysis.
Zhang X, Yu D, Sun J, Wu Y, Gong J, Li X, Liu L, Liu S, Liu J, Wu Y, Li D, Ma Y, Han X, Zhu Y, Wu Z, Wang Y, Ouyang Q, Wang T.
Zhang X, et al.
Structure. 2020 May 5;28(5):555-561.e4. doi: 10.1016/j.str.2020.03.007. Epub 2020 Apr 9.
Structure. 2020.
PMID: 32275863
Free article.
However, the complete structure of the receptor and the signal transduction mechanism remains unclear. Here, we report the cryo-EM structure of the ligand-bound ectodomain in the full-length human IGF-1R. We reconstructed the IGF-1R/insulin …
However, the complete structure of the receptor and the signal transduction mechanism remains unclear. Here, we report the …