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Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase that favorably modulates lipid mediator biosynthesis in inflammation.
Cheung SY, Werner M, Esposito L, Troisi F, Cantone V, Liening S, König S, Gerstmeier J, Koeberle A, Bilancia R, Rizza R, Rossi A, Roviezzo F, Temml V, Schuster D, Stuppner H, Schubert-Zsilavecz M, Werz O, Hanke T, Pace S. Cheung SY, et al. Among authors: stuppner h. Eur J Med Chem. 2018 Aug 5;156:815-830. doi: 10.1016/j.ejmech.2018.07.031. Epub 2018 Jul 25. Eur J Med Chem. 2018. PMID: 30053720
11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches.
Rollinger JM, Kratschmar DV, Schuster D, Pfisterer PH, Gumy C, Aubry EM, Brandstötter S, Stuppner H, Wolber G, Odermatt A. Rollinger JM, et al. Among authors: stuppner h. Bioorg Med Chem. 2010 Feb 15;18(4):1507-15. doi: 10.1016/j.bmc.2010.01.010. Epub 2010 Jan 11. Bioorg Med Chem. 2010. PMID: 20100662
Pharmacophore-based discovery of a novel cytosolic phospholipase A(2)α inhibitor.
Noha SM, Jazzar B, Kuehnl S, Rollinger JM, Stuppner H, Schaible AM, Werz O, Wolber G, Schuster D. Noha SM, et al. Among authors: stuppner h. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1202-7. doi: 10.1016/j.bmcl.2011.11.093. Epub 2011 Nov 30. Bioorg Med Chem Lett. 2012. PMID: 22192589 Free PMC article.
273 results