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The 3' untranslated region of messenger RNA: A molecular 'hotspot' for pathology?
Conne B, Stutz A, Vassalli JD. Conne B, et al. Among authors: stutz a. Nat Med. 2000 Jun;6(6):637-41. doi: 10.1038/76211. Nat Med. 2000. PMID: 10835679 Review.
Induction of enhanced green fluorescent protein expression in response to lesions in the nervous system.
Dubois-Dauphin M, Eder-Colli L, Vallet P, Stutz A, Nef S, Vassalli JD. Dubois-Dauphin M, et al. Among authors: stutz a. J Comp Neurol. 2004 Jun 14;474(1):108-22. doi: 10.1002/cne.20122. J Comp Neurol. 2004. PMID: 15156581
We have generated a mouse strain carrying a transgene driven by a strong and ubiquitous promoter (human cytomegalovirus hCMV/beta-actin) and containing an enhanced green fluorescent protein (eGFP) coding sequence upstream of the 3' untranslated region (3'UTR) …
We have generated a mouse strain carrying a transgene driven by a strong and ubiquitous promoter (human cytomegalovirus …
Masking, unmasking, and regulated polyadenylation cooperate in the translational control of a dormant mRNA in mouse oocytes.
Stutz A, Conne B, Huarte J, Gubler P, Völkel V, Flandin P, Vassalli JD. Stutz A, et al. Genes Dev. 1998 Aug 15;12(16):2535-48. doi: 10.1101/gad.12.16.2535. Genes Dev. 1998. PMID: 9716406 Free PMC article.
We show that binding of a approximately 80-kD protein to a UA-rich element in the 3' UTR of tissue-type plasminogen activator mRNA, a mouse oocyte mRNA that is translated during meiotic maturation, silences the mRNA in primary oocytes. Translation can be trig …
We show that binding of a approximately 80-kD protein to a UA-rich element in the 3' UTR of tissue-type plasminogen activator …
In vivo antisense oligodeoxynucleotide mapping reveals masked regulatory elements in an mRNA dormant in mouse oocytes.
Stutz A, Huarte J, Gubler P, Conne B, Belin D, Vassalli JD. Stutz A, et al. Mol Cell Biol. 1997 Apr;17(4):1759-67. doi: 10.1128/mcb.17.4.1759. Mol Cell Biol. 1997. PMID: 9121423 Free PMC article.
During the first hour of meiotic maturation, part of the ACE and the AAUAAA hexanucleotide became accessible to hybridization, suggesting a partial unmasking of the 3'UTR of this mRNA before it becomes translationally competent. Our results demonstrate that in vivo antisen …
During the first hour of meiotic maturation, part of the ACE and the AAUAAA hexanucleotide became accessible to hybridization, suggesting …
Transient translational silencing by reversible mRNA deadenylation.
Huarte J, Stutz A, O'Connell ML, Gubler P, Belin D, Darrow AL, Strickland S, Vassalli JD. Huarte J, et al. Among authors: stutz a. Cell. 1992 Jun 12;69(6):1021-30. doi: 10.1016/0092-8674(92)90620-r. Cell. 1992. PMID: 1606611
Dormancy is associated with an unusually short poly(A) tail, and poly(A) tail elongation controls tPA mRNA translational activation during meiotic maturation. ...The translation of a reporter mRNA in primary oocytes is prevented upon inclusion of an ACE in it …
Dormancy is associated with an unusually short poly(A) tail, and poly(A) tail elongation controls tPA mRNA translational activ …
Translational control. Awakening dormant mRNAs.
Vassalli JD, Stutz A. Vassalli JD, et al. Among authors: stutz a. Curr Biol. 1995 May 1;5(5):476-9. doi: 10.1016/s0960-9822(95)00095-9. Curr Biol. 1995. PMID: 7583092 Review.
The translational control of many maternal mRNAs in oocytes and early embryos relies on changes in poly(A) tail length; the factors controlling poly(A) tail length are being identified in a range of species....
The translational control of many maternal mRNAs in oocytes and early embryos relies on changes in poly(A) tail length; the factors c …
Acquisition of meiotic competence in growing mouse oocytes is controlled at both translational and posttranslational levels.
de Vantéry C, Stutz A, Vassalli JD, Schorderet-Slatkine S. de Vantéry C, et al. Among authors: stutz a. Dev Biol. 1997 Jul 1;187(1):43-54. doi: 10.1006/dbio.1997.8599. Dev Biol. 1997. PMID: 9224673
Entry into M phase of the eukaryotic cell cycle is controlled by MPF, a catalytically active complex comprising p34cdc2 kinase and cyclin B. ...Thus, endogenous cyclin B1 in incompetent oocytes is not available for interaction with p34cdc2, suggesting that a posttra …
Entry into M phase of the eukaryotic cell cycle is controlled by MPF, a catalytically active complex comprising p34cdc2 kinase and cy …
The MIntAct project--IntAct as a common curation platform for 11 molecular interaction databases.
Orchard S, Ammari M, Aranda B, Breuza L, Briganti L, Broackes-Carter F, Campbell NH, Chavali G, Chen C, del-Toro N, Duesbury M, Dumousseau M, Galeota E, Hinz U, Iannuccelli M, Jagannathan S, Jimenez R, Khadake J, Lagreid A, Licata L, Lovering RC, Meldal B, Melidoni AN, Milagros M, Peluso D, Perfetto L, Porras P, Raghunath A, Ricard-Blum S, Roechert B, Stutz A, Tognolli M, van Roey K, Cesareni G, Hermjakob H. Orchard S, et al. Among authors: stutz a. Nucleic Acids Res. 2014 Jan;42(Database issue):D358-63. doi: 10.1093/nar/gkt1115. Epub 2013 Nov 13. Nucleic Acids Res. 2014. PMID: 24234451 Free PMC article.
IntAct has developed a sophisticated web-based curation tool, capable of supporting both IMEx- and MIMIx-level curation. This tool is now utilized by multiple additional curation teams, all of whom annotate data directly into the IntAct database. ...
IntAct has developed a sophisticated web-based curation tool, capable of supporting both IMEx- and MIMIx-level curation. This tool is …
Gene Ontology annotations and resources.
Gene Ontology Consortium, Blake JA, Dolan M, Drabkin H, Hill DP, Li N, Sitnikov D, Bridges S, Burgess S, Buza T, McCarthy F, Peddinti D, Pillai L, Carbon S, Dietze H, Ireland A, Lewis SE, Mungall CJ, Gaudet P, Chrisholm RL, Fey P, Kibbe WA, Basu S, Siegele DA, McIntosh BK, Renfro DP, Zweifel AE, Hu JC, Brown NH, Tweedie S, Alam-Faruque Y, Apweiler R, Auchinchloss A, Axelsen K, Bely B, Blatter M-, Bonilla C, Bouguerleret L, Boutet E, Breuza L, Bridge A, Chan WM, Chavali G, Coudert E, Dimmer E, Estreicher A, Famiglietti L, Feuermann M, Gos A, Gruaz-Gumowski N, Hieta R, Hinz C, Hulo C, Huntley R, James J, Jungo F, Keller G, Laiho K, Legge D, Lemercier P, Lieberherr D, Magrane M, Martin MJ, Masson P, Mutowo-Muellenet P, O'Donovan C, Pedruzzi I, Pichler K, Poggioli D, Porras Millán P, Poux S, Rivoire C, Roechert B, Sawford T, Schneider M, Stutz A, Sundaram S, Tognolli M, Xenarios I, Foulgar R, Lomax J, Roncaglia P, Khodiyar VK, Lovering RC, Talmud PJ, Chibucos M, Giglio MG, Chang H-, Hunter S, McAnulla C, Mitchell A, Sangrador A, Stephan R, Harris MA, Oliver SG, Rutherford K, Wood V, Bahler J, Lock A, Kersey PJ, McDowall DM, Staines DM, Dwinell M, Shimoyama M, Laulederkind S, Hayman T, Wang S-, Petri V, Lowry T, D'Eustachio P, Matthews L, Balakrishnan R, Binkley G, Cherry JM, Costanzo MC, Dwight SS, Engel SR, Fisk DG, Hitz BC, Hong EL, Karra K, Miyasato SR, Nash RS, Park J, Skrzypek MS, Weng S, Wong ED, Berardini TZ, Huala E, Mi H, Thomas PD, Chan J, Kishore R, Sternberg P, Van Auken K, Howe D, Westerfield M. Gene Ontology Consortium, et al. Among authors: stutz a. Nucleic Acids Res. 2013 Jan;41(Database issue):D530-5. doi: 10.1093/nar/gks1050. Epub 2012 Nov 17. Nucleic Acids Res. 2013. PMID: 23161678 Free PMC article.
Second, as a result of a new 'phylogenetic annotation' process, manually reviewed, homology-based annotations are becoming available for a broad range of species. Third, the quality of GO annotations has been improved through a streamlined process for, …
Second, as a result of a new 'phylogenetic annotation' process, manually reviewed, homology-based annotations are becoming ava …
The UniProt-GO Annotation database in 2011.
Dimmer EC, Huntley RP, Alam-Faruque Y, Sawford T, O'Donovan C, Martin MJ, Bely B, Browne P, Mun Chan W, Eberhardt R, Gardner M, Laiho K, Legge D, Magrane M, Pichler K, Poggioli D, Sehra H, Auchincloss A, Axelsen K, Blatter MC, Boutet E, Braconi-Quintaje S, Breuza L, Bridge A, Coudert E, Estreicher A, Famiglietti L, Ferro-Rojas S, Feuermann M, Gos A, Gruaz-Gumowski N, Hinz U, Hulo C, James J, Jimenez S, Jungo F, Keller G, Lemercier P, Lieberherr D, Masson P, Moinat M, Pedruzzi I, Poux S, Rivoire C, Roechert B, Schneider M, Stutz A, Sundaram S, Tognolli M, Bougueleret L, Argoud-Puy G, Cusin I, Duek-Roggli P, Xenarios I, Apweiler R. Dimmer EC, et al. Among authors: stutz a. Nucleic Acids Res. 2012 Jan;40(Database issue):D565-70. doi: 10.1093/nar/gkr1048. Epub 2011 Nov 28. Nucleic Acids Res. 2012. PMID: 22123736 Free PMC article.
Currently supplying over 100 million annotations to 11 million proteins in more than 360,000 taxa, this resource has increased 2-fold over the last 2 years and has benefited from a wealth of checks to improve annotation correctness and consistency as well as now supplying …
Currently supplying over 100 million annotations to 11 million proteins in more than 360,000 taxa, this resource has increased 2-fold over t …
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