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The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C.
Facchinetti V, Ouyang W, Wei H, Soto N, Lazorchak A, Gould C, Lowry C, Newton AC, Mao Y, Miao RQ, Sessa WC, Qin J, Zhang P, Su B, Jacinto E. Facchinetti V, et al. EMBO J. 2008 Jul 23;27(14):1932-43. doi: 10.1038/emboj.2008.120. Epub 2008 Jun 19. EMBO J. 2008. PMID: 18566586 Free PMC article.
Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells.
Lazorchak AS, Liu D, Facchinetti V, Di Lorenzo A, Sessa WC, Schatz DG, Su B. Lazorchak AS, et al. Mol Cell. 2010 Aug 13;39(3):433-43. doi: 10.1016/j.molcel.2010.07.031. Mol Cell. 2010. PMID: 20705244 Free PMC article.
PI3K signaling regulates B cell development, homeostasis, and immune responses. However, the function and molecular mechanism of mTOR-mediated PI3K signaling in B cells has not been fully elucidated. ...Our study reveals that the Sin1/mTORC2-Akt2 signaling axis is a …
PI3K signaling regulates B cell development, homeostasis, and immune responses. However, the function and molecular mechanism of mTOR …
mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide.
Oh WJ, Wu CC, Kim SJ, Facchinetti V, Julien LA, Finlan M, Roux PP, Su B, Jacinto E. Oh WJ, et al. EMBO J. 2010 Dec 1;29(23):3939-51. doi: 10.1038/emboj.2010.271. Epub 2010 Nov 2. EMBO J. 2010. PMID: 21045808 Free PMC article.
mTOR complex 2 targets Akt for proteasomal degradation via phosphorylation at the hydrophobic motif.
Wu YT, Ouyang W, Lazorchak AS, Liu D, Shen HM, Su B. Wu YT, et al. J Biol Chem. 2011 Apr 22;286(16):14190-8. doi: 10.1074/jbc.M111.219923. Epub 2011 Feb 14. J Biol Chem. 2011. PMID: 21321111 Free PMC article.
The protein kinase Akt (also known as protein kinase B) is a critical signaling hub downstream of various cellular stimuli such as growth factors that control cell survival, growth, and proliferation. ...
The protein kinase Akt (also known as protein kinase B) is a critical signaling hub downstream of various cellular stimuli such as gr …
Perspectives on the role of mTORC2 in B lymphocyte development, immunity and tumorigenesis.
Lazorchak AS, Su B. Lazorchak AS, et al. Protein Cell. 2011 Jul;2(7):523-30. doi: 10.1007/s13238-011-1077-3. Epub 2011 Aug 6. Protein Cell. 2011. PMID: 21822797 Free PMC article. Review.
We have recently explored the functions of mTORC2 in B cells and show that mTORC2 plays a key role in regulating survival and immunoglobulin (Ig) gene recombination of bone marrow B cells through an Akt2-FoxO1 dependent mechanism. ...Our results raise the possibilit …
We have recently explored the functions of mTORC2 in B cells and show that mTORC2 plays a key role in regulating survival and immunog …
Regulatory effects of mTORC2 complexes in type I IFN signaling and in the generation of IFN responses.
Kaur S, Sassano A, Majchrzak-Kita B, Baker DP, Su B, Fish EN, Platanias LC. Kaur S, et al. Proc Natl Acad Sci U S A. 2012 May 15;109(20):7723-8. doi: 10.1073/pnas.1118122109. Epub 2012 May 1. Proc Natl Acad Sci U S A. 2012. PMID: 22550181 Free PMC article.
mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8.
Kim SJ, DeStefano MA, Oh WJ, Wu CC, Vega-Cotto NM, Finlan M, Liu D, Su B, Jacinto E. Kim SJ, et al. Mol Cell. 2012 Dec 28;48(6):875-87. doi: 10.1016/j.molcel.2012.09.029. Epub 2012 Nov 8. Mol Cell. 2012. PMID: 23142081 Free PMC article.
Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.
Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, Lee TH, Asara JM, Manning BD, Blenis J, Su B, Wei W. Liu P, et al. Nat Cell Biol. 2013 Nov;15(11):1340-50. doi: 10.1038/ncb2860. Epub 2013 Oct 27. Nat Cell Biol. 2013. PMID: 24161930 Free PMC article.
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