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MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM.
Casaletto JB, Geddie ML, Abu-Yousif AO, Masson K, Fulgham A, Boudot A, Maiwald T, Kearns JD, Kohli N, Su S, Razlog M, Raue A, Kalra A, Håkansson M, Logan DT, Welin M, Chattopadhyay S, Harms BD, Nielsen UB, Schoeberl B, Lugovskoy AA, MacBeath G. Casaletto JB, et al. Proc Natl Acad Sci U S A. 2019 Apr 9;116(15):7533-7542. doi: 10.1073/pnas.1819085116. Epub 2019 Mar 21. Proc Natl Acad Sci U S A. 2019. PMID: 30898885 Free PMC article.
Durable anticancer immunity from intratumoral administration of IL-23, IL-36γ, and OX40L mRNAs.
Hewitt SL, Bai A, Bailey D, Ichikawa K, Zielinski J, Karp R, Apte A, Arnold K, Zacharek SJ, Iliou MS, Bhatt K, Garnaas M, Musenge F, Davis A, Khatwani N, Su SV, MacLean G, Farlow SJ, Burke K, Frederick JP. Hewitt SL, et al. Among authors: su sv. Sci Transl Med. 2019 Jan 30;11(477):eaat9143. doi: 10.1126/scitranslmed.aat9143. Sci Transl Med. 2019. PMID: 30700577
mRNA structure regulates protein expression through changes in functional half-life.
Mauger DM, Cabral BJ, Presnyak V, Su SV, Reid DW, Goodman B, Link K, Khatwani N, Reynders J, Moore MJ, McFadyen IJ. Mauger DM, et al. Among authors: su sv. Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24075-24083. doi: 10.1073/pnas.1908052116. Epub 2019 Nov 11. Proc Natl Acad Sci U S A. 2019. PMID: 31712433 Free PMC article.
Impact of mRNA chemistry and manufacturing process on innate immune activation.
Nelson J, Sorensen EW, Mintri S, Rabideau AE, Zheng W, Besin G, Khatwani N, Su SV, Miracco EJ, Issa WJ, Hoge S, Stanton MG, Joyal JL. Nelson J, et al. Among authors: su sv. Sci Adv. 2020 Jun 24;6(26):eaaz6893. doi: 10.1126/sciadv.aaz6893. eCollection 2020 Jun. Sci Adv. 2020. PMID: 32637598 Free PMC article.
Gene set enrichment in eQTL data identifies novel annotations and pathway regulators.
Wu C, Delano DL, Mitro N, Su SV, Janes J, McClurg P, Batalov S, Welch GL, Zhang J, Orth AP, Walker JR, Glynne RJ, Cooke MP, Takahashi JS, Shimomura K, Kohsaka A, Bass J, Saez E, Wiltshire T, Su AI. Wu C, et al. Among authors: su sv. PLoS Genet. 2008 May 9;4(5):e1000070. doi: 10.1371/journal.pgen.1000070. PLoS Genet. 2008. PMID: 18464898 Free PMC article.
12 results