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Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus.
Rabinovitch A, Suarez-Pinzon WL. Rabinovitch A, et al. Biochem Pharmacol. 1998 Apr 15;55(8):1139-49. doi: 10.1016/s0006-2952(97)00492-9. Biochem Pharmacol. 1998. PMID: 9719467 Review.
Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta-cells from cytokine-induced destruction.
Rabinovitch A, Suarez-Pinzon W, Strynadka K, Ju Q, Edelstein D, Brownlee M, Korbutt GS, Rajotte RV. Rabinovitch A, et al. Diabetes. 1999 Jun;48(6):1223-9. doi: 10.2337/diabetes.48.6.1223. Diabetes. 1999. PMID: 10342808
Testicular sertoli cells protect islet beta-cells from autoimmune destruction in NOD mice by a transforming growth factor-beta1-dependent mechanism.
Suarez-Pinzon W, Korbutt GS, Power R, Hooton J, Rajotte RV, Rabinovitch A. Suarez-Pinzon W, et al. Diabetes. 2000 Nov;49(11):1810-8. doi: 10.2337/diabetes.49.11.1810. Diabetes. 2000. PMID: 11078447
Beta-cell destruction in NOD mice correlates with Fas (CD95) expression on beta-cells and proinflammatory cytokine expression in islets.
Suarez-Pinzon W, Sorensen O, Bleackley RC, Elliott JF, Rajotte RV, Rabinovitch A. Suarez-Pinzon W, et al. Diabetes. 1999 Jan;48(1):21-8. doi: 10.2337/diabetes.48.1.21. Diabetes. 1999. PMID: 9892218
Cytokine gene expression in pancreatic islet-infiltrating leukocytes of BB rats: expression of Th1 cytokines correlates with beta-cell destructive insulitis and IDDM.
Rabinovitch A, Suarez-Pinzon W, El-Sheikh A, Sorensen O, Power RF. Rabinovitch A, et al. Diabetes. 1996 Jun;45(6):749-54. doi: 10.2337/diab.45.6.749. Diabetes. 1996. PMID: 8635648
Both CD4+ and CD8+ T-cells in syngeneic islet grafts in NOD mice produce interferon-gamma during beta-cell destruction.
Suarez-Pinzon W, Rajotte RV, Mosmann TR, Rabinovitch A. Suarez-Pinzon W, et al. Diabetes. 1996 Oct;45(10):1350-7. doi: 10.2337/diab.45.10.1350. Diabetes. 1996. PMID: 8826970
Combination therapy with epidermal growth factor and gastrin increases beta-cell mass and reverses hyperglycemia in diabetic NOD mice.
Suarez-Pinzon WL, Yan Y, Power R, Brand SJ, Rabinovitch A. Suarez-Pinzon WL, et al. Diabetes. 2005 Sep;54(9):2596-601. doi: 10.2337/diabetes.54.9.2596. Diabetes. 2005. PMID: 16123347 Free article.
Combination therapy with epidermal growth factor and gastrin induces neogenesis of human islet {beta}-cells from pancreatic duct cells and an increase in functional {beta}-cell mass.
Suarez-Pinzon WL, Lakey JR, Brand SJ, Rabinovitch A. Suarez-Pinzon WL, et al. J Clin Endocrinol Metab. 2005 Jun;90(6):3401-9. doi: 10.1210/jc.2004-0761. Epub 2005 Mar 15. J Clin Endocrinol Metab. 2005. PMID: 15769977
Role of cytokines in the pathogenesis of autoimmune diabetes mellitus.
Rabinovitch A, Suarez-Pinzon WL. Rabinovitch A, et al. Rev Endocr Metab Disord. 2003 Sep;4(3):291-9. doi: 10.1023/a:1025160614313. Rev Endocr Metab Disord. 2003. PMID: 14501180 Review. No abstract available.
Poly (ADP-ribose) polymerase inhibition prevents spontaneous and recurrent autoimmune diabetes in NOD mice by inducing apoptosis of islet-infiltrating leukocytes.
Suarez-Pinzon WL, Mabley JG, Power R, Szabó C, Rabinovitch A. Suarez-Pinzon WL, et al. Diabetes. 2003 Jul;52(7):1683-8. doi: 10.2337/diabetes.52.7.1683. Diabetes. 2003. PMID: 12829633
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