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Hydrophilic anilinogeranyl diphosphate prenyl analogues are Ras function inhibitors.
Roberts MJ, Troutman JM, Chehade KA, Cha HC, Kao JP, Huang X, Zhan CG, Peterson YK, Subramanian T, Kamalakkannan S, Andres DA, Spielmann HP. Roberts MJ, et al. Among authors: subramanian t. Biochemistry. 2006 Dec 26;45(51):15862-72. doi: 10.1021/bi061704+. Epub 2006 Dec 6. Biochemistry. 2006. PMID: 17176109
Anticancer activity of novel unnatural synthetic isoprenoids.
Adams VR, Deremer DL, Stevich B, Mattingly CA, Gallt B, Subramanian T, Troutman JM, Spielmann HP. Adams VR, et al. Among authors: subramanian t. Anticancer Res. 2010 Jul;30(7):2505-12. Anticancer Res. 2010. PMID: 20682975
Formation of a Novel Macrocyclic Alkaloid from the Unnatural Farnesyl Diphosphate Analogue Anilinogeranyl Diphosphate by 5-Epi-Aristolochene Synthase.
Rising KA, Crenshaw CM, Koo HJ, Subramanian T, Chehade KA, Starks C, Allen KD, Andres DA, Spielmann HP, Noel JP, Chappell J. Rising KA, et al. Among authors: subramanian t. ACS Chem Biol. 2015 Jul 17;10(7):1729-36. doi: 10.1021/acschembio.5b00145. Epub 2015 May 4. ACS Chem Biol. 2015. PMID: 25897591 Free PMC article.
Functional characterization of the atypical integral membrane lipid phosphatase PDP1/PPAPDC2 identifies a pathway for interconversion of isoprenols and isoprenoid phosphates in mammalian cells.
Miriyala S, Subramanian T, Panchatcharam M, Ren H, McDermott MI, Sunkara M, Drennan T, Smyth SS, Spielmann HP, Morris AJ. Miriyala S, et al. Among authors: subramanian t. J Biol Chem. 2010 Apr 30;285(18):13918-29. doi: 10.1074/jbc.M109.083931. Epub 2010 Jan 28. J Biol Chem. 2010. PMID: 20110354 Free PMC article.
282 results