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102 results

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Page 1
Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV.
Mitton-Fry MJ, Brickner SJ, Hamel JC, Brennan L, Casavant JM, Chen M, Chen T, Ding X, Driscoll J, Hardink J, Hoang T, Hua E, Huband MD, Maloney M, Marfat A, McCurdy SP, McLeod D, Plotkin M, Reilly U, Robinson S, Schafer J, Shepard RM, Smith JF, Stone GG, Subramanyam C, Yoon K, Yuan W, Zaniewski RP, Zook C. Mitton-Fry MJ, et al. Among authors: subramanyam c. Bioorg Med Chem Lett. 2013 May 15;23(10):2955-61. doi: 10.1016/j.bmcl.2013.03.047. Epub 2013 Mar 21. Bioorg Med Chem Lett. 2013. PMID: 23566517
Novel 3-fluoro-6-methoxyquinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV.
Mitton-Fry MJ, Brickner SJ, Hamel JC, Barham R, Brennan L, Casavant JM, Ding X, Finegan S, Hardink J, Hoang T, Huband MD, Maloney M, Marfat A, McCurdy SP, McLeod D, Subramanyam C, Plotkin M, Reilly U, Schafer J, Stone GG, Uccello DP, Wisialowski T, Yoon K, Zaniewski R, Zook C. Mitton-Fry MJ, et al. Among authors: subramanyam c. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3353-3358. doi: 10.1016/j.bmcl.2017.06.009. Epub 2017 Jun 3. Bioorg Med Chem Lett. 2017. PMID: 28610977
Pyrimidine benzamide-based thrombopoietin receptor agonists.
Reiter LA, Subramanyam C, Mangual EJ, Jones CS, Smeets MI, Brissette WH, McCurdy SP, Lira PD, Linde RG, Li Q, Zhang F, Antipas AS, Blumberg LC, Doty JL, Driscoll JP, Munchhof MJ, Ripp SL, Shavnya A, Shepard RM, Sperger D, Thomasco LM, Trevena KA, Wolf-Gouveia LA, Zhang L. Reiter LA, et al. Among authors: subramanyam c. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5447-54. doi: 10.1016/j.bmcl.2007.07.038. Epub 2007 Jul 31. Bioorg Med Chem Lett. 2007. PMID: 17707640
Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14.
Blagg JA, Noe MC, Wolf-Gouveia LA, Reiter LA, Laird ER, Chang SP, Danley DE, Downs JT, Elliott NC, Eskra JD, Griffiths RJ, Hardink JR, Haugeto AI, Jones CS, Liras JL, Lopresti-Morrow LL, Mitchell PG, Pandit J, Robinson RP, Subramanyam C, Vaughn-Bowser ML, Yocum SA. Blagg JA, et al. Among authors: subramanyam c. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1807-10. doi: 10.1016/j.bmcl.2005.02.038. Bioorg Med Chem Lett. 2005. PMID: 15780611
Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection.
Flanagan ME, Blumenkopf TA, Brissette WH, Brown MF, Casavant JM, Shang-Poa C, Doty JL, Elliott EA, Fisher MB, Hines M, Kent C, Kudlacz EM, Lillie BM, Magnuson KS, McCurdy SP, Munchhof MJ, Perry BD, Sawyer PS, Strelevitz TJ, Subramanyam C, Sun J, Whipple DA, Changelian PS. Flanagan ME, et al. Among authors: subramanyam c. J Med Chem. 2010 Dec 23;53(24):8468-84. doi: 10.1021/jm1004286. Epub 2010 Nov 24. J Med Chem. 2010. PMID: 21105711
Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535.
Duplantier AJ, Dombroski MA, Subramanyam C, Beaulieu AM, Chang SP, Gabel CA, Jordan C, Kalgutkar AS, Kraus KG, Labasi JM, Mussari C, Perregaux DG, Shepard R, Taylor TJ, Trevena KA, Whitney-Pickett C, Yoon K. Duplantier AJ, et al. Among authors: subramanyam c. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3708-11. doi: 10.1016/j.bmcl.2011.04.077. Epub 2011 Apr 24. Bioorg Med Chem Lett. 2011. PMID: 21565499
Optimization of Tubulysin Antibody-Drug Conjugates: A Case Study in Addressing ADC Metabolism.
Tumey LN, Leverett CA, Vetelino B, Li F, Rago B, Han X, Loganzo F, Musto S, Bai G, Sukuru SC, Graziani EI, Puthenveetil S, Casavant J, Ratnayake A, Marquette K, Hudson S, Doppalapudi VR, Stock J, Tchistiakova L, Bessire AJ, Clark T, Lucas J, Hosselet C, O'Donnell CJ, Subramanyam C. Tumey LN, et al. Among authors: subramanyam c. ACS Med Chem Lett. 2016 Jun 22;7(11):977-982. doi: 10.1021/acsmedchemlett.6b00195. eCollection 2016 Nov 10. ACS Med Chem Lett. 2016. PMID: 27882194 Free PMC article.
Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active γ-secretase modulators.
Pettersson M, Johnson DS, Subramanyam C, Bales KR, am Ende CW, Fish BA, Green ME, Kauffman GW, Lira R, Mullins PB, Navaratnam T, Sakya SM, Stiff CM, Tran TP, Vetelino BC, Xie L, Zhang L, Pustilnik LR, Wood KM, O'Donnell CJ. Pettersson M, et al. Among authors: subramanyam c. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2906-11. doi: 10.1016/j.bmcl.2012.02.059. Epub 2012 Mar 1. Bioorg Med Chem Lett. 2012. PMID: 22429469
102 results