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Sucrose octaacetate.
Stagner WC, Gaddam S, Parmar R, Ghanta AK. Stagner WC, et al. Profiles Drug Subst Excip Relat Methodol. 2019;44:267-291. doi: 10.1016/bs.podrm.2019.02.002. Epub 2019 Mar 8. Profiles Drug Subst Excip Relat Methodol. 2019. PMID: 31029220
Sucrose octaacetate (SOA) is a United States National Formulary (NF) monograph compendial material (U.S. Pharmacopeia, 2008), and, as shown in Fig. 1, has eight acetate groups attached to a sucrose moiety. It is a natural product that has been extracted from
Sucrose octaacetate (SOA) is a United States National Formulary (NF) monograph compendial material (U.S. Pharmacopeia, 2008),
Sucrose Octaacetate Chemical Kinetics and Shelf Lives at Various Formulation pHs.
Gaddam S, Stagner WC. Gaddam S, et al. AAPS PharmSciTech. 2018 Jan;19(1):176-183. doi: 10.1208/s12249-017-0829-7. Epub 2017 Jun 23. AAPS PharmSciTech. 2018. PMID: 28646247
Developing pediatric friendly dosage forms is a high priority worldwide. Sucrose octaacetate (SOA) has been recommended for use as a surrogate for bitter tasting active pharmaceutical ingredients. ...
Developing pediatric friendly dosage forms is a high priority worldwide. Sucrose octaacetate (SOA) has been recommended for us …
A formulation for suppressing bitter taste in the human oral cavity.
Smutzer G, Cherian S, Patel D, Lee BS, Lee K, Sotelo AR, Mitchell KW. Smutzer G, et al. Physiol Behav. 2020 Nov 1;226:113129. doi: 10.1016/j.physbeh.2020.113129. Epub 2020 Aug 11. Physiol Behav. 2020. PMID: 32791180
Stearic acid microspheres were prepared that successfully encapsulated the bitter taste stimulus sucrose octaacetate. Sucrose octaacetate microspheres were then embedded in rapidly dissolving edible films for psychophysical studies. ...These results we …
Stearic acid microspheres were prepared that successfully encapsulated the bitter taste stimulus sucrose octaacetate. Sucro
Sucrose octaacetate-taster mice have more vallate taste buds than non-tasters.
Miller IJ Jr, Whitney G. Miller IJ Jr, et al. Neurosci Lett. 1989 May 22;100(1-3):271-5. doi: 10.1016/0304-3940(89)90697-6. Neurosci Lett. 1989. PMID: 2761777
Taste buds were counted in two strains of mice which have been characterized in terms of their taste avoidance of the bitter-tasting substance, sucrose octaacetate (SOA). One strain (SWR/J) avoids SOA and is referred to as "taster' while the other strain (C57BL/6J) …
Taste buds were counted in two strains of mice which have been characterized in terms of their taste avoidance of the bitter-tasting substan …
Enzymatic synthesis of sucrose octaacetate using a novel alkaline protease.
Li G, Cai Y, Liao X, Yin J. Li G, et al. Biotechnol Lett. 2011 Mar;33(3):607-10. doi: 10.1007/s10529-010-0468-5. Epub 2010 Nov 12. Biotechnol Lett. 2011. PMID: 21072559
Sucrose octaacetate was the sole product and more than 90% sucrose was converted in 24 h at 30C. The purity of sucrose octaacetate reached 100%, via a simple purification method of alcohol/water washing and centrifugation....
Sucrose octaacetate was the sole product and more than 90% sucrose was converted in 24 h at 30C. The purity of sucro
Sucrose octaacetate avoidance in nontaster mice is not enhanced by two type-A Prp transgenes from taster mice.
Harder DB, Azen EA, Whitney G. Harder DB, et al. Chem Senses. 2000 Feb;25(1):39-45. doi: 10.1093/chemse/25.1.39. Chem Senses. 2000. PMID: 10667992
The Soa bitter-sensitivity and Prp salivary-protein loci map to distal mouse chromosome six. No recombination has been found between sucrose octaacetate (SOA)-avoidance phenotype and PRP haplotype in any mouse population. ...
The Soa bitter-sensitivity and Prp salivary-protein loci map to distal mouse chromosome six. No recombination has been found between sucr
Chromosome mapping of Soa, a gene influencing gustatory sensitivity to sucrose octaacetate in mice.
Capeless CG, Whitney G, Azen EA. Capeless CG, et al. Behav Genet. 1992 Nov;22(6):655-63. doi: 10.1007/BF01066636. Behav Genet. 1992. PMID: 1290451
Strain distribution patterns among recombinant inbred strains suggested that a locus influencing taste sensitivity to sucrose octaacetate was on chromosome 6. A location for Soa was established by linkage analysis of behavioral and electrophoretic data from outbred …
Strain distribution patterns among recombinant inbred strains suggested that a locus influencing taste sensitivity to sucrose octa
Statistical Optimization of Evaporative Light Scattering Detection for Molten Sucrose Octaacetate and Comparison With Ultraviolet Diode Array Detection Validation Parameters Using Tandem HPLC Ultraviolet Diode Array Detection/Evaporative Light Scattering Detection-Specific Stability-Indicating Method.
Parmar R, Ghanta A, Haware RV, Johnson PR, Stagner WC. Parmar R, et al. J Pharm Sci. 2016 Dec;105(12):3603-3610. doi: 10.1016/j.xphs.2016.08.030. Epub 2016 Oct 25. J Pharm Sci. 2016. PMID: 27793345
A sucrose octaacetate (SOA) gradient HPLC evaporative light scattering detection (ELSD) and low-wavelength UV-diode array detection (UV-DAD)-specific stability-indicating method development and validation comparison is reported. ...
A sucrose octaacetate (SOA) gradient HPLC evaporative light scattering detection (ELSD) and low-wavelength UV-diode array dete …
B6-MSM consomic mouse strains reveal multiple loci for genetic variation in sucrose octaacetate aversion.
Ishii A, Koide T, Takahashi A, Shiroishi T, Hettinger TP, Frank ME, Savoy LD, Formaker BK, Yertutanol S, Lionikas A, Blizard DA. Ishii A, et al. Behav Genet. 2011 Sep;41(5):716-23. doi: 10.1007/s10519-011-9464-3. Epub 2011 Apr 3. Behav Genet. 2011. PMID: 21461901
Based on crosses among inbred strains derived principally from M. m. domesticus, sucrose octaacetate (SOA) aversion in laboratory mice has been thought for many years to be controlled by a single genetic locus (Soa) located on distal chromosome (Chr) 6. ...
Based on crosses among inbred strains derived principally from M. m. domesticus, sucrose octaacetate (SOA) aversion in laborat …
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