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Emergence of hepatitis C virus NS5A L31V plus Y93H variant upon treatment failure of daclatasvir and asunaprevir is relatively resistant to ledipasvir and NS5B polymerase nucleotide inhibitor GS-558093 in human hepatocyte chimeric mice.
Kai Y, Hikita H, Tatsumi T, Nakabori T, Saito Y, Morishita N, Tanaka S, Nawa T, Oze T, Sakamori R, Yakushijin T, Hiramatsu N, Suemizu H, Takehara T. Kai Y, et al. J Gastroenterol. 2015 Nov;50(11):1145-51. doi: 10.1007/s00535-015-1108-6. Epub 2015 Jul 25. J Gastroenterol. 2015. PMID: 26208695
Human urine and plasma concentrations of bisphenol A extrapolated from pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and semi-physiological pharmacokinetic modeling.
Miyaguchi T, Suemizu H, Shimizu M, Shida S, Nishiyama S, Takano R, Murayama N, Yamazaki H. Miyaguchi T, et al. Regul Toxicol Pharmacol. 2015 Jun;72(1):71-6. doi: 10.1016/j.yrtph.2015.03.010. Epub 2015 Mar 21. Regul Toxicol Pharmacol. 2015. PMID: 25805149
The Hepatitis B Virus Genotype Affects the Persistence of Viral Replication in Immunodeficient NOG Mice.
Yokoyama Y, Miyagi T, Hikita H, Yoshioka T, Mukai K, Nawa T, Sakamori R, Ohkawa K, Hiramatsu N, Takahashi T, Suemizu H, Ryo A, Tatsumi T, Takehara T. Yokoyama Y, et al. PLoS One. 2015 Dec 14;10(12):e0144775. doi: 10.1371/journal.pone.0144775. eCollection 2015. PLoS One. 2015. PMID: 26658490 Free PMC article.
Sodium taurocholate cotransporting polypeptide inhibition efficiently blocks hepatitis B virus spread in mice with a humanized liver.
Nakabori T, Hikita H, Murai K, Nozaki Y, Kai Y, Makino Y, Saito Y, Tanaka S, Wada H, Eguchi H, Takahashi T, Suemizu H, Sakamori R, Hiramatsu N, Tatsumi T, Takehara T. Nakabori T, et al. Sci Rep. 2016 Jun 9;6:27782. doi: 10.1038/srep27782. Sci Rep. 2016. PMID: 27278060 Free PMC article.
Simulation of human plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling.
Kamimura H, Ito S, Chijiwa H, Okuzono T, Ishiguro T, Yamamoto Y, Nishinoaki S, Ninomiya SI, Mitsui M, Kalgutkar AS, Yamazaki H, Suemizu H. Kamimura H, et al. Xenobiotica. 2017 May;47(5):382-393. doi: 10.1080/00498254.2016.1199063. Epub 2016 Jul 7. Xenobiotica. 2017. PMID: 27389028
Baseline quasispecies selection and novel mutations contribute to emerging resistance-associated substitutions in hepatitis C virus after direct-acting antiviral treatment.
Kai Y, Hikita H, Morishita N, Murai K, Nakabori T, Iio S, Hagiwara H, Imai Y, Tamura S, Tsutsui S, Naito M, Nishiuchi M, Kondo Y, Kato T, Suemizu H, Yamada R, Oze T, Yakushijin T, Hiramatsu N, Sakamori R, Tatsumi T, Takehara T. Kai Y, et al. Sci Rep. 2017 Jan 30;7:41660. doi: 10.1038/srep41660. Sci Rep. 2017. PMID: 28134353 Free PMC article.
Human plasma metabolic profiles of benzydamine, a flavin-containing monooxygenase probe substrate, simulated with pharmacokinetic data from control and humanized-liver mice.
Yamazaki-Nishioka M, Shimizu M, Suemizu H, Nishiwaki M, Mitsui M, Yamazaki H. Yamazaki-Nishioka M, et al. Xenobiotica. 2018 Feb;48(2):117-123. doi: 10.1080/00498254.2017.1288280. Epub 2017 Feb 21. Xenobiotica. 2018. PMID: 28145791
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