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Isoleucine, a blood glucose-lowering amino acid, increases glucose uptake in rat skeletal muscle in the absence of increases in AMP-activated protein kinase activity.
Doi M, Yamaoka I, Nakayama M, Mochizuki S, Sugahara K, Yoshizawa F. Doi M, et al. Among authors: sugahara k. J Nutr. 2005 Sep;135(9):2103-8. doi: 10.1093/jn/135.9.2103. J Nutr. 2005. PMID: 16140883
Time course of leucine-induced 4E-BP1 and S6K1 phosphorylation in the liver and skeletal muscle of rats.
Yoshizawa F, Sekizawa H, Hirayama S, Hatakeyama A, Nagasawa T, Sugahara K. Yoshizawa F, et al. Among authors: sugahara k. J Nutr Sci Vitaminol (Tokyo). 2001 Aug;47(4):311-5. doi: 10.3177/jnsv.47.311. J Nutr Sci Vitaminol (Tokyo). 2001. PMID: 11767213
Hypoglycemic effect of isoleucine involves increased muscle glucose uptake and whole body glucose oxidation and decreased hepatic gluconeogenesis.
Doi M, Yamaoka I, Nakayama M, Sugahara K, Yoshizawa F. Doi M, et al. Among authors: sugahara k. Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1683-93. doi: 10.1152/ajpendo.00609.2006. Epub 2007 Feb 13. Am J Physiol Endocrinol Metab. 2007. PMID: 17299083
Insulin mediates the linkage acceleration of muscle protein synthesis, thermogenesis, and heat storage by amino acids.
Yamaoka I, Doi M, Kawano Y, Nakayama M, Watanabe Y, Oba K, Sugahara K, Yoshizawa F. Yamaoka I, et al. Among authors: sugahara k. Biochem Biophys Res Commun. 2009 Aug 14;386(1):252-6. doi: 10.1016/j.bbrc.2009.06.031. Epub 2009 Jun 10. Biochem Biophys Res Commun. 2009. PMID: 19523452
Differential dose response of mTOR signaling to oral administration of leucine in skeletal muscle and liver of rats.
Yoshizawa F, Mochizuki S, Sugahara K. Yoshizawa F, et al. Among authors: sugahara k. Biosci Biotechnol Biochem. 2013;77(4):839-42. doi: 10.1271/bbb.120737. Epub 2013 Apr 7. Biosci Biotechnol Biochem. 2013. PMID: 23563533
Ethionine-induced ATP depletion represses mTOR signaling in the absence of increases in AMP-activated protein kinase activity in the rat liver.
Yoshizawa F, Mochizuki S, Doi M, Yamaoka I, Sugahara K. Yoshizawa F, et al. Among authors: sugahara k. Biosci Biotechnol Biochem. 2009 Sep;73(9):1984-8. doi: 10.1271/bbb.90154. Epub 2009 Sep 7. Biosci Biotechnol Biochem. 2009. PMID: 19734680
Intravenous administration of amino acids during anesthesia stimulates muscle protein synthesis and heat accumulation in the body.
Yamaoka I, Doi M, Nakayama M, Ozeki A, Mochizuki S, Sugahara K, Yoshizawa F. Yamaoka I, et al. Among authors: sugahara k. Am J Physiol Endocrinol Metab. 2006 May;290(5):E882-8. doi: 10.1152/ajpendo.00333.2005. Epub 2005 Dec 13. Am J Physiol Endocrinol Metab. 2006. PMID: 16352675
We examined the changes of intraperitoneal temperature (Tcore) and the rates of protein synthesis (K(s)) and the phosphorylation states of translation initiation regulators and their upstream signaling components in skeletal muscle in conscious (Nor) or propofol-anesthetiz …
We examined the changes of intraperitoneal temperature (Tcore) and the rates of protein synthesis (K(s)) and the phosphorylation stat …
Tissue-specific regulation of 4E-BP1 and S6K1 phosphorylation by alpha-ketoisocaproate.
Yoshizawa F, Sekizawa H, Hirayama S, Yamazaki Y, Nagasawa T, Sugahara K. Yoshizawa F, et al. Among authors: sugahara k. J Nutr Sci Vitaminol (Tokyo). 2004 Feb;50(1):56-60. doi: 10.3177/jnsv.50.56. J Nutr Sci Vitaminol (Tokyo). 2004. PMID: 15228219
Oral administration of leucine stimulates phosphorylation of 4E-bP1 and S6K 1 in skeletal muscle but not in liver of diabetic rats.
Yoshizawa F, Hirayama S, Sekizawa H, Nagasawa T, Sugahara K. Yoshizawa F, et al. Among authors: sugahara k. J Nutr Sci Vitaminol (Tokyo). 2002 Feb;48(1):59-64. doi: 10.3177/jnsv.48.59. J Nutr Sci Vitaminol (Tokyo). 2002. PMID: 12026190
Circadian rhythms and energy metabolism with special reference to the suprachiasmatic nucleus.
Nagai K, Nagai N, Sugahara K, Niijima A, Nakagawa H. Nagai K, et al. Among authors: sugahara k. Neurosci Biobehav Rev. 1994 Winter;18(4):579-84. doi: 10.1016/0149-7634(94)90014-0. Neurosci Biobehav Rev. 1994. PMID: 7708372 Review.
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