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A plant phytotoxin, solanapyrone A, is an inhibitor of DNA polymerase beta and lambda.
Mizushina Y, Kamisuki S, Kasai N, Shimazaki N, Takemura M, Asahara H, Linn S, Yoshida S, Matsukage A, Koiwai O, Sugawara F, Yoshida H, Sakaguchi K. Mizushina Y, et al. Among authors: sugawara f. J Biol Chem. 2002 Jan 4;277(1):630-8. doi: 10.1074/jbc.M105144200. Epub 2001 Oct 24. J Biol Chem. 2002. PMID: 11677229 Free article.
A sulphoquinovosyl diacylglycerol is a DNA polymerase epsilon inhibitor.
Mizushina Y, Xu X, Asahara H, Takeuchi R, Oshige M, Shimazaki N, Takemura M, Yamaguchi T, Kuroda K, Linn S, Yoshida H, Koiwai O, Saneyoshi M, Sugawara F, Sakaguchi K. Mizushina Y, et al. Among authors: sugawara f. Biochem J. 2003 Feb 15;370(Pt 1):299-305. doi: 10.1042/BJ20021737. Biochem J. 2003. PMID: 12435270 Free PMC article.
Petasiphenol: a DNA polymerase lambda inhibitor.
Mizushina Y, Kamisuki S, Kasai N, Ishidoh T, Shimazaki N, Takemura M, Asahara H, Linn S, Yoshida S, Koiwai O, Sugawara F, Yoshida H, Sakaguchi K. Mizushina Y, et al. Among authors: sugawara f. Biochemistry. 2002 Dec 10;41(49):14463-71. doi: 10.1021/bi020476q. Biochemistry. 2002. PMID: 12463744
Some anti-chronic inflammatory compounds are DNA polymerase lambda-specific inhibitors.
Mizushina Y, Hirota M, Murakami C, Ishidoh T, Kamisuki S, Shimazaki N, Takemura M, Perpelescu M, Suzuki M, Yoshida H, Sugawara F, Koiwai O, Sakaguchi K. Mizushina Y, et al. Among authors: sugawara f. Biochem Pharmacol. 2003 Nov 15;66(10):1935-44. doi: 10.1016/s0006-2952(03)00551-3. Biochem Pharmacol. 2003. PMID: 14599551
Inhibitory action of emulsified sulfoquinovosyl acylglycerol on mammalian DNA polymerases.
Mizushina Y, Maeda N, Kawasaki M, Ichikawa H, Murakami C, Takemura M, Xu X, Sugawara F, Fukumori Y, Yoshida H, Sakaguchi K. Mizushina Y, et al. Among authors: sugawara f. Lipids. 2003 Oct;38(10):1065-74. doi: 10.1007/s11745-006-1162-1. Lipids. 2003. PMID: 14669972
., Torigoe, T., Hanashima, S., Yamazaki, T., Takahashi, S., Sugawara, F., et al., An Immunosuppressive Effect by Synthetic Sulfonolipids Deduced from Sulfonoquinovosyl Diacylglycerols of Sea Urchin, Transplantation 74, 261-267 (2002); Sahara, H., Hanashima, S., Yama …
., Torigoe, T., Hanashima, S., Yamazaki, T., Takahashi, S., Sugawara, F., et al., An Immunosuppressive Effect by Synthetic Sul …
Structural relationship of lithocholic acid derivatives binding to the N-terminal 8-kDa domain of DNA polymerase beta.
Mizushina Y, Kasai N, Miura K, Hanashima S, Takemura M, Yoshida H, Sugawara F, Sakaguchi K. Mizushina Y, et al. Among authors: sugawara f. Biochemistry. 2004 Aug 24;43(33):10669-77. doi: 10.1021/bi049307r. Biochemistry. 2004. PMID: 15311928
We reported previously that lithocholic acid (LCA, 3-alpha-hydroxy-5-beta-cholan-24-oic acid), one of the major compounds in the secondary bile acids, selectively inhibited the activity of mammalian DNA polymerase beta (pol beta) [Mizushina, Y., Ohkubo, T., Sugawara, F …
We reported previously that lithocholic acid (LCA, 3-alpha-hydroxy-5-beta-cholan-24-oic acid), one of the major compounds in the secondary b …
232 results