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Discovery of 1,5-benzodiazepines with peripheral cholecystokinin (CCK-A) receptor agonist activity. 1. Optimization of the agonist "trigger".
Aquino CJ, Armour DR, Berman JM, Birkemo LS, Carr RA, Croom DK, Dezube M, Dougherty RW Jr, Ervin GN, Grizzle MK, Head JE, Hirst GC, James MK, Johnson MF, Miller LJ, Queen KL, Rimele TJ, Smith DN, Sugg EE. Aquino CJ, et al. Among authors: sugg ee. J Med Chem. 1996 Jan 19;39(2):562-9. doi: 10.1021/jm950626d. J Med Chem. 1996. PMID: 8558528
Discovery of 1,5-benzodiazepines with peripheral cholecystokinin (CCK-A) receptor agonist activity (II): Optimization of the C3 amino substituent.
Hirst GC, Aquino C, Birkemo L, Croom DK, Dezube M, Dougherty RW Jr, Ervin GN, Grizzle MK, Henke B, James MK, Johnson MF, Momtahen T, Queen KL, Sherrill RG, Szewczyk J, Willson TM, Sugg EE. Hirst GC, et al. Among authors: sugg ee. J Med Chem. 1996 Dec 20;39(26):5236-45. doi: 10.1021/jm9601664. J Med Chem. 1996. PMID: 8978852
1,4-Benzodiazepine peripheral cholecystokinin (CCK-A) receptor agonists.
Sherrill RG, Berman JM, Birkemo L, Croom DK, Dezube M, Ervin GN, Grizzle MK, James MK, Johnson MF, Queen KL, Rimele TJ, Vanmiddlesworth F, Sugg EE. Sherrill RG, et al. Among authors: sugg ee. Bioorg Med Chem Lett. 2001 May 7;11(9):1145-8. doi: 10.1016/s0960-894x(01)00164-0. Bioorg Med Chem Lett. 2001. PMID: 11354363
Orally active nonpeptide CCK-A agonists.
Sugg EE, Birkemo L, Gan LS, Tippin TK. Sugg EE, et al. Pharm Biotechnol. 1998;11:507-24. doi: 10.1007/0-306-47384-4_22. Pharm Biotechnol. 1998. PMID: 9760694 Review. No abstract available.
Synthesis and evaluation of potent and selective beta(3) adrenergic receptor agonists containing acylsulfonamide, sulfonylsulfonamide, and sulfonylurea carboxylic acid isosteres.
Uehling DE, Donaldson KH, Deaton DN, Hyman CE, Sugg EE, Barrett DG, Hughes RG, Reitter B, Adkison KK, Lancaster ME, Lee F, Hart R, Paulik MA, Sherman BW, True T, Cowan C. Uehling DE, et al. Among authors: sugg ee. J Med Chem. 2002 Jan 31;45(3):567-83. doi: 10.1021/jm0101500. J Med Chem. 2002. PMID: 11806709
33 results