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Novel phorbol analogs which bind to protein kinase C (PKC) without activation.
Sugita K, Sawada D, Sodeoka M, Sasai H, Shibasaki M. Sugita K, et al. Chem Pharm Bull (Tokyo). 1996 Feb;44(2):463-5. doi: 10.1248/cpb.44.463. Chem Pharm Bull (Tokyo). 1996. PMID: 8998847
Fms-like tyrosine kinase 3 ligand stimulation induces MLL-rearranged leukemia cells into quiescence resistant to antileukemic agents.
Furuichi Y, Goi K, Inukai T, Sato H, Nemoto A, Takahashi K, Akahane K, Hirose K, Honna H, Kuroda I, Zhang X, Kagami K, Hayashi Y, Harigaya K, Nakazawa S, Sugita K. Furuichi Y, et al. Cancer Res. 2007 Oct 15;67(20):9852-61. doi: 10.1158/0008-5472.CAN-07-0105. Cancer Res. 2007. PMID: 17942916
C/EBPalpha and C/EBPvarepsilon induce the monocytic differentiation of myelomonocytic cells with the MLL-chimeric fusion gene.
Matsushita H, Nakajima H, Nakamura Y, Tsukamoto H, Tanaka Y, Jin G, Yabe M, Asai S, Ono R, Nosaka T, Sugita K, Morimoto A, Hayashi Y, Hotta T, Ando K, Miyachi H. Matsushita H, et al. Oncogene. 2008 Dec 4;27(53):6749-60. doi: 10.1038/onc.2008.285. Epub 2008 Sep 8. Oncogene. 2008. PMID: 18776924
HMGA2 as a potential molecular target in KMT2A-AFF1-positive infant acute lymphoblastic leukaemia.
Wu Z, Eguchi-Ishimae M, Yagi C, Iwabuki H, Gao W, Tauchi H, Inukai T, Sugita K, Ishii E, Eguchi M. Wu Z, et al. Br J Haematol. 2015 Dec;171(5):818-29. doi: 10.1111/bjh.13763. Epub 2015 Sep 25. Br J Haematol. 2015. PMID: 26403224
Specific Antileukemic Activity of PD0332991, a CDK4/6 Inhibitor, against Philadelphia Chromosome-Positive Lymphoid Leukemia.
Nemoto A, Saida S, Kato I, Kikuchi J, Furukawa Y, Maeda Y, Akahane K, Honna-Oshiro H, Goi K, Kagami K, Kimura S, Sato Y, Okabe S, Niwa A, Watanabe K, Nakahata T, Heike T, Sugita K, Inukai T. Nemoto A, et al. Mol Cancer Ther. 2016 Jan;15(1):94-105. doi: 10.1158/1535-7163.MCT-14-1065. Epub 2015 Dec 4. Mol Cancer Ther. 2016. PMID: 26637365
Poly (ADP-ribose) polymerase inhibitors selectively induce cytotoxicity in TCF3-HLF-positive leukemic cells.
Piao J, Takai S, Kamiya T, Inukai T, Sugita K, Ohyashiki K, Delia D, Masutani M, Mizutani S, Takagi M. Piao J, et al. Cancer Lett. 2017 Feb 1;386:131-140. doi: 10.1016/j.canlet.2016.11.021. Epub 2016 Nov 25. Cancer Lett. 2017. PMID: 27894958
TGFβ1 synergizes with FLT3 ligand to induce chemoresistant quiescence in acute lymphoblastic leukemia with MLL gene rearrangements.
Tamai M, Furuichi Y, Kasai S, Ando N, Harama D, Goi K, Inukai T, Kagami K, Abe M, Ichikawa H, Sugita K. Tamai M, et al. Leuk Res. 2017 Oct;61:68-76. doi: 10.1016/j.leukres.2017.08.013. Epub 2017 Sep 14. Leuk Res. 2017. PMID: 28917156
p16/MTS1/INK4A gene is frequently inactivated by hypermethylation in childhood acute lymphoblastic leukemia with 11q23 translocation.
Nakamura M, Sugita K, Inukai T, Goi K, Iijima K, Tezuka T, Kojika S, Shiraishi K, Miyamoto N, Karakida N, Kagami K, O-Koyama T, Mori T, Nakazawa S. Nakamura M, et al. Leukemia. 1999 Jun;13(6):884-90. doi: 10.1038/sj.leu.2401437. Leukemia. 1999. PMID: 10360377
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