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2,372 results
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Genetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs.
Ieiri I, Higuchi S, Sugiyama Y. Ieiri I, et al. Among authors: sugiyama y. Expert Opin Drug Metab Toxicol. 2009 Jul;5(7):703-29. doi: 10.1517/17425250902976854. Expert Opin Drug Metab Toxicol. 2009. PMID: 19442037 Review.
Kinetic analysis of hepatobiliary transport of vincristine in perfused rat liver. Possible roles of P-glycoprotein in biliary excretion of vincristine.
Watanabe T, Miyauchi S, Sawada Y, Iga T, Hanano M, Inaba M, Sugiyama Y. Watanabe T, et al. Among authors: sugiyama y. J Hepatol. 1992 Sep;16(1-2):77-88. doi: 10.1016/s0168-8278(05)80098-4. J Hepatol. 1992. PMID: 1362433
[Kinetics of receptor-mediated endocytosis of polypeptide hormones that governs the overall hormone disposition in the body: analysis of the uptake process of epidermal growth factor by the liver and kidney].
Sugiyama Y. Sugiyama Y. Yakugaku Zasshi. 1991 Dec;111(12):709-36. doi: 10.1248/yakushi1947.111.12_709. Yakugaku Zasshi. 1991. PMID: 1806655 Review. Japanese.
Protein-mediated hepatic uptake of rose bengal in analbuminemic mutant rats (NAR). Albumin is not indispensable to the protein-mediated transport of rose bengal.
Tsao SC, Sugiyama Y, Shinmura K, Sawada Y, Nagase S, Iga T, Hanano M. Tsao SC, et al. Among authors: sugiyama y. Drug Metab Dispos. 1988 May-Jun;16(3):482-9. Drug Metab Dispos. 1988. PMID: 2457477
Physiologically based pharmacokinetics of radioiodinated human beta-endorphin in rats. An application of the capillary membrane-limited model.
Sato H, Sugiyama Y, Sawada Y, Iga T, Hanano M. Sato H, et al. Among authors: sugiyama y. Drug Metab Dispos. 1987 Jul-Aug;15(4):540-50. Drug Metab Dispos. 1987. PMID: 2888629
Effect of serum from renal failure and cirrhotic patients on the blood-brain barrier permeability to DL-propranolol in rats.
Lin TH, Sugiyama Y, Sawada Y, Kawasaki S, Iga T, Hanano M. Lin TH, et al. Among authors: sugiyama y. Drug Metab Dispos. 1988 Mar-Apr;16(2):290-5. Drug Metab Dispos. 1988. PMID: 2898349
Efflux of cimetidine from the rat cerebrospinal fluid.
Suzuki H, Sawada Y, Sugiyama Y, Iga T, Hanano M. Suzuki H, et al. Among authors: sugiyama y. Drug Metab Dispos. 1988 Mar-Apr;16(2):328-30. Drug Metab Dispos. 1988. PMID: 2898356 No abstract available.
Construction of a physiologically based pharmacokinetic model to describe the hepatobiliary excretion process of ligands: quantitative estimation of intracellular diffusion.
Sathirakul K, Suzuki H, Yasuda K, Hanano M, Sugiyama Y. Sathirakul K, et al. Among authors: sugiyama y. Biol Pharm Bull. 1993 Mar;16(3):273-9. doi: 10.1248/bpb.16.273. Biol Pharm Bull. 1993. PMID: 8364472
Na(+)-independent multispecific anion transporter mediates active transport of pravastatin into rat liver.
Yamazaki M, Suzuki H, Hanano M, Tokui T, Komai T, Sugiyama Y. Yamazaki M, et al. Among authors: sugiyama y. Am J Physiol. 1993 Jan;264(1 Pt 1):G36-44. doi: 10.1152/ajpgi.1993.264.1.G36. Am J Physiol. 1993. PMID: 8430803
Applications and prospects for physiologically based pharmacokinetic (PB-PK) models involving pharmaceutical agents.
Suzuki H, Iwatsubo T, Sugiyama Y. Suzuki H, et al. Among authors: sugiyama y. Toxicol Lett. 1995 Dec;82-83:349-55. doi: 10.1016/0378-4274(95)03488-9. Toxicol Lett. 1995. PMID: 8597076 Review.
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