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Synthesis of 4,5-disubstituted-2-thioxo-1,2,3,4-tetrahydropyrimidines and investigation of their acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase I/II inhibitory and antioxidant activities.
Garibov E, Taslimi P, Sujayev A, Bingol Z, Çetinkaya S, Gulçin İ, Beydemir S, Farzaliyev V, Alwasel SH, Supuran CT. Garibov E, et al. J Enzyme Inhib Med Chem. 2016;31(sup3):1-9. doi: 10.1080/14756366.2016.1198901. Epub 2016 Jun 22. J Enzyme Inhib Med Chem. 2016. PMID: 27329935 Free article.
The antioxidant activity of the cyclic thioureas was investigated by using different in vitro antioxidant assays, including 1,1-diphenyl-2-picrylhydrazyl (DPPH.) radical scavenging, Cu(2+ )and Fe(3+ )reducing, and Fe(2+ )chelating activities....
The antioxidant activity of the cyclic thioureas was investigated by using different in vitro antioxidant assays, including 1,1 …
Synthesis of some tetrahydropyrimidine-5-carboxylates, determination of their metal chelating effects and inhibition profiles against acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase.
Sujayev A, Garibov E, Taslimi P, Gulçin İ, Gojayeva S, Farzaliyev V, Alwasel SH, Supuran CT. Sujayev A, et al. J Enzyme Inhib Med Chem. 2016 Dec;31(6):1531-9. doi: 10.3109/14756366.2016.1156104. Epub 2016 Mar 28. J Enzyme Inhib Med Chem. 2016. PMID: 27050248 Free article.
2-(Methacryloyloxy)ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate, is a cyclic urea derivative synthesized from urea, 2-(methacryloyloxy) ethyl acetoacetate and substituted benzaldehyde, and tested in terms of the inhibition of two physiologically …
2-(Methacryloyloxy)ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate, is a cyclic urea derivative synthesized …
Synthesis of N-alkyl (aril)-tetra pyrimidine thiones and investigation of their human carbonic anhydrase I and II inhibitory effects.
Sujayev A, Polat Kose L, Garibov E, Gülçin İ, Farzaliev V, Alwasel SH, Supuran CT. Sujayev A, et al. J Enzyme Inhib Med Chem. 2016 Dec;31(6):1192-7. doi: 10.3109/14756366.2015.1113172. Epub 2015 Nov 19. J Enzyme Inhib Med Chem. 2016. PMID: 26586381 Free article.
A tautomeric form of these derivatives incorporates the thiol functionality, which is known to interact with metal ions from metalloenzymes active sites, such as the carbonic anhydrases (CAs, EC 4.2.1.1) among others. This is a superfamily of widespread enzymes, whi …
A tautomeric form of these derivatives incorporates the thiol functionality, which is known to interact with metal ions from metalloenzymes …