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Regulatory T cells engineered with TCR signaling-responsive IL-2 nanogels suppress alloimmunity in sites of antigen encounter.
Eskandari SK, Sulkaj I, Melo MB, Li N, Allos H, Alhaddad JB, Kollar B, Borges TJ, Eskandari AS, Zinter MA, Cai S, Assaker JP, Choi JY, Al Dulaijan BS, Mansouri A, Haik Y, Tannous BA, van Son WJ, Leuvenink HGD, Pomahac B, Riella LV, Tang L, Seelen MAJ, Irvine DJ, Azzi JR. Eskandari SK, et al. Among authors: sulkaj i. Sci Transl Med. 2020 Nov 11;12(569):eaaw4744. doi: 10.1126/scitranslmed.aaw4744. Sci Transl Med. 2020. PMID: 33177180 Free PMC article.
Regulatory CD8 T cells that recognize Qa-1 expressed by CD4 T-helper cells inhibit rejection of heart allografts.
Choi JY, Eskandari SK, Cai S, Sulkaj I, Assaker JP, Allos H, AlHaddad J, Muhsin SA, Alhussain E, Mansouri A, Yeung MY, Seelen MAJ, Kim HJ, Cantor H, Azzi JR. Choi JY, et al. Among authors: sulkaj i. Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):6042-6046. doi: 10.1073/pnas.1918950117. Epub 2020 Feb 28. Proc Natl Acad Sci U S A. 2020. PMID: 32111690 Free PMC article.
mTORC1 Inhibition Protects Human Regulatory T Cells From Granzyme-B-Induced Apoptosis.
Eskandari SK, Allos H, Al Dulaijan BS, Melhem G, Sulkaj I, Alhaddad JB, Saad AJ, Deban C, Chu P, Choi JY, Kollar B, Pomahac B, Riella LV, Berger SP, Sanders JSF, Lieberman J, Li L, Azzi JR. Eskandari SK, et al. Among authors: sulkaj i. Front Immunol. 2022 Jun 10;13:899975. doi: 10.3389/fimmu.2022.899975. eCollection 2022. Front Immunol. 2022. PMID: 35757726 Free PMC article.
Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity.
Ma L, Hostetler A, Morgan DM, Maiorino L, Sulkaj I, Whittaker CA, Neeser A, Pires IS, Yousefpour P, Gregory J, Qureshi K, Dye J, Abraham W, Suh H, Li N, Love JC, Irvine DJ. Ma L, et al. Among authors: sulkaj i. Cell. 2023 Jul 20;186(15):3148-3165.e20. doi: 10.1016/j.cell.2023.06.002. Epub 2023 Jul 5. Cell. 2023. PMID: 37413990 Free PMC article.
Increased Dopamine Type 2 Gene Expression in the Dorsal Striatum in Individuals With Autism Spectrum Disorder Suggests Alterations in Indirect Pathway Signaling and Circuitry.
Brandenburg C, Soghomonian JJ, Zhang K, Sulkaj I, Randolph B, Kachadoorian M, Blatt GJ. Brandenburg C, et al. Among authors: sulkaj i. Front Cell Neurosci. 2020 Nov 9;14:577858. doi: 10.3389/fncel.2020.577858. eCollection 2020. Front Cell Neurosci. 2020. PMID: 33240045 Free PMC article.