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MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme.
Li Y, Ivica NA, Dong T, Papageorgiou DP, He Y, Brown DR, Kleyman M, Hu G, Chen WW, Sullivan LB, Del Rosario A, Hammond PT, Vander Heiden MG, Chen J. Li Y, et al. Among authors: sullivan lb. Nat Commun. 2020 Sep 24;11(1):4837. doi: 10.1038/s41467-020-18607-1. Nat Commun. 2020. PMID: 32973183 Free PMC article.
Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer.
Davidson SM, Papagiannakopoulos T, Olenchock BA, Heyman JE, Keibler MA, Luengo A, Bauer MR, Jha AK, O'Brien JP, Pierce KA, Gui DY, Sullivan LB, Wasylenko TM, Subbaraj L, Chin CR, Stephanopolous G, Mott BT, Jacks T, Clish CB, Vander Heiden MG. Davidson SM, et al. Among authors: sullivan lb. Cell Metab. 2016 Mar 8;23(3):517-28. doi: 10.1016/j.cmet.2016.01.007. Epub 2016 Feb 4. Cell Metab. 2016. PMID: 26853747 Free PMC article.
Biophysical changes reduce energetic demand in growth factor-deprived lymphocytes.
Hecht VC, Sullivan LB, Kimmerling RJ, Kim DH, Hosios AM, Stockslager MA, Stevens MM, Kang JH, Wirtz D, Vander Heiden MG, Manalis SR. Hecht VC, et al. Among authors: sullivan lb. J Cell Biol. 2016 Feb 15;212(4):439-47. doi: 10.1083/jcb.201506118. J Cell Biol. 2016. PMID: 26880201 Free PMC article.
EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection.
Olenchock BA, Moslehi J, Baik AH, Davidson SM, Williams J, Gibson WJ, Chakraborty AA, Pierce KA, Miller CM, Hanse EA, Kelekar A, Sullivan LB, Wagers AJ, Clish CB, Vander Heiden MG, Kaelin WG Jr. Olenchock BA, et al. Among authors: sullivan lb. Cell. 2016 Feb 25;164(5):884-95. doi: 10.1016/j.cell.2016.02.006. Cell. 2016. PMID: 26919427 Free PMC article.
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu-Remaileh M, Shaul YD, Liu CM, Zhou M, Koh MJ, Chung H, Davidson SM, Luengo A, Wang AQ, Xu X, Yasgar A, Liu L, Rai G, Westover KD, Vander Heiden MG, Shen M, Gray NS, Boxer MB, Sabatini DM. Pacold ME, et al. Among authors: sullivan lb. Nat Chem Biol. 2016 Jun;12(6):452-8. doi: 10.1038/nchembio.2070. Epub 2016 Apr 25. Nat Chem Biol. 2016. PMID: 27110680 Free PMC article.
Aspartate is an endogenous metabolic limitation for tumour growth.
Sullivan LB, Luengo A, Danai LV, Bush LN, Diehl FF, Hosios AM, Lau AN, Elmiligy S, Malstrom S, Lewis CA, Vander Heiden MG. Sullivan LB, et al. Nat Cell Biol. 2018 Jul;20(7):782-788. doi: 10.1038/s41556-018-0125-0. Epub 2018 Jun 25. Nat Cell Biol. 2018. PMID: 29941931 Free PMC article.
Increased demand for NAD+ relative to ATP drives aerobic glycolysis.
Luengo A, Li Z, Gui DY, Sullivan LB, Zagorulya M, Do BT, Ferreira R, Naamati A, Ali A, Lewis CA, Thomas CJ, Spranger S, Matheson NJ, Vander Heiden MG. Luengo A, et al. Among authors: sullivan lb. Mol Cell. 2021 Feb 18;81(4):691-707.e6. doi: 10.1016/j.molcel.2020.12.012. Epub 2020 Dec 30. Mol Cell. 2021. PMID: 33382985 Free PMC article.
44 results