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PERM1 regulates energy metabolism in the heart via ERRα/PGC-1α axis.
Oka SI, Sreedevi K, Shankar TS, Yedla S, Arowa S, James A, Stone KG, Olmos K, Sabry AD, Horiuchi A, Cawley KM, O'very SA, Tong M, Byun J, Xu X, Kashyap S, Mourad Y, Vehra O, Calder D, Lunde T, Liu T, Li H, Mashchek JA, Cox J, Saijoh Y, Drakos SG, Warren JS. Oka SI, et al. Among authors: arowa s. Front Cardiovasc Med. 2022 Nov 7;9:1033457. doi: 10.3389/fcvm.2022.1033457. eCollection 2022. Front Cardiovasc Med. 2022. PMID: 36419485 Free PMC article.
Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype.
Nuechterlein N, Shelbourn A, Szulzewsky F, Arora S, Casad M, Pattwell S, Merino-Galan L, Sulman E, Arowa S, Alvinez N, Jung M, Brown D, Tang K, Jackson S, Stoica S, Chittaboina P, Banasavadi-Siddegowda YK, Wirsching HG, Stella N, Shapiro L, Paddison P, Patel AP, Gilbert MR, Abdullaev Z, Aldape K, Pratt D, Holland EC, Cimino PJ. Nuechterlein N, et al. Among authors: arowa s. Genes Dev. 2024 Apr 17;38(5-6):273-288. doi: 10.1101/gad.351350.123. Genes Dev. 2024. PMID: 38589034 Free PMC article.
Loss of PDE10A is associated with metastasis of colon adenocarcinoma.
Arowa S, Nuechterlein N, Ha V, Shelbourn A, Chowdhury A, Banasavadi-Siddegowda YK, Lasota J, Miettinen M, Cimino PJ. Arowa S, et al. Histol Histopathol. 2026 Feb;41(2):235-243. doi: 10.14670/HH-18-951. Epub 2025 Jun 16. Histol Histopathol. 2026. PMID: 40548384