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Indole-3-carbinol triggers aryl hydrocarbon receptor-dependent estrogen receptor (ER)alpha protein degradation in breast cancer cells disrupting an ERalpha-GATA3 transcriptional cross-regulatory loop.

Marconett CN, Sundar SN, Poindexter KM, Stueve TR, Bjeldanes LF, Firestone GL. Marconett CN, et al. Among authors: sundar sn. Mol Biol Cell. 2010 Apr 1;21(7):1166-77. doi: 10.1091/mbc.e09-08-0689. Epub 2010 Feb 3. Mol Biol Cell. 2010. PMID: 20130088 Free PMC article.

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Anticancer activities of artemisinin and its bioactive derivatives.

Firestone GL, Sundar SN. Firestone GL, et al. Among authors: sundar sn. Expert Rev Mol Med. 2009 Oct 30;11:e32. doi: 10.1017/S1462399409001239. Expert Rev Mol Med. 2009. PMID: 19883518 Review.

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Minireview: modulation of hormone receptor signaling by dietary anticancer indoles.

Firestone GL, Sundar SN. Firestone GL, et al. Among authors: sundar sn. Mol Endocrinol. 2009 Dec;23(12):1940-7. doi: 10.1210/me.2009-0149. Epub 2009 Oct 16. Mol Endocrinol. 2009. PMID: 19837944 Free PMC article. Review.

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Artemisinin disrupts androgen responsiveness of human prostate cancer cells by stimulating the 26S proteasome-mediated degradation of the androgen receptor protein.

Steely AM, Willoughby JA Sr, Sundar SN, Aivaliotis VI, Firestone GL. Steely AM, et al. Among authors: sundar sn. Anticancer Drugs. 2017 Oct;28(9):1018-1031. doi: 10.1097/CAD.0000000000000547. Anticancer Drugs. 2017. PMID: 28708672

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Essential role of the cancer stem/progenitor cell marker nucleostemin for indole-3-carbinol anti-proliferative responsiveness in human breast cancer cells.

Tin AS, Park AH, Sundar SN, Firestone GL. Tin AS, et al. Among authors: sundar sn. BMC Biol. 2014 Sep 12;12:72. doi: 10.1186/s12915-014-0072-6. BMC Biol. 2014. PMID: 25209720 Free PMC article.

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Indole-3-carbinol disrupts estrogen receptor-alpha dependent expression of insulin-like growth factor-1 receptor and insulin receptor substrate-1 and proliferation of human breast cancer cells.

Marconett CN, Singhal AK, Sundar SN, Firestone GL. Marconett CN, et al. Among authors: sundar sn. Mol Cell Endocrinol. 2012 Nov 5;363(1-2):74-84. doi: 10.1016/j.mce.2012.07.008. Epub 2012 Jul 24. Mol Cell Endocrinol. 2012. PMID: 22835548 Free PMC article.

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Antiproliferative effects of artemisinin on human breast cancer cells requires the downregulated expression of the E2F1 transcription factor and loss of E2F1-target cell cycle genes.

Tin AS, Sundar SN, Tran KQ, Park AH, Poindexter KM, Firestone GL. Tin AS, et al. Among authors: sundar sn. Anticancer Drugs. 2012 Apr;23(4):370-9. doi: 10.1097/CAD.0b013e32834f6ea8. Anticancer Drugs. 2012. PMID: 22185819

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Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition of estrogen receptor-alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates the G1 cell cycle arrest of human breast cancer cells.

Marconett CN, Sundar SN, Tseng M, Tin AS, Tran KQ, Mahuron KM, Bjeldanes LF, Firestone GL. Marconett CN, et al. Among authors: sundar sn. Carcinogenesis. 2011 Sep;32(9):1315-23. doi: 10.1093/carcin/bgr116. Epub 2011 Jun 21. Carcinogenesis. 2011. PMID: 21693539 Free PMC article.

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1-Benzyl-indole-3-carbinol is a novel indole-3-carbinol derivative with significantly enhanced potency of anti-proliferative and anti-estrogenic properties in human breast cancer cells.

Nguyen HH, Lavrenov SN, Sundar SN, Nguyen DH, Tseng M, Marconett CN, Kung J, Staub RE, Preobrazhenskaya MN, Bjeldanes LF, Firestone GL. Nguyen HH, et al. Among authors: sundar sn. Chem Biol Interact. 2010 Aug 5;186(3):255-66. doi: 10.1016/j.cbi.2010.05.015. Epub 2010 Jun 2. Chem Biol Interact. 2010. PMID: 20570586 Free PMC article.

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BZL101, a phytochemical extract from the Scutellaria barbata plant, disrupts proliferation of human breast and prostate cancer cells through distinct mechanisms dependent on the cancer cell phenotype.

Marconett CN, Morgenstern TJ, San Roman AK, Sundar SN, Singhal AK, Firestone GL. Marconett CN, et al. Among authors: sundar sn. Cancer Biol Ther. 2010 Aug 15;10(4):397-405. doi: 10.4161/cbt.10.4.12424. Epub 2010 Aug 20. Cancer Biol Ther. 2010. PMID: 20574166 Free PMC article.

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