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Indole-3-carbinol triggers aryl hydrocarbon receptor-dependent estrogen receptor (ER)alpha protein degradation in breast cancer cells disrupting an ERalpha-GATA3 transcriptional cross-regulatory loop.
Marconett CN, Sundar SN, Poindexter KM, Stueve TR, Bjeldanes LF, Firestone GL. Marconett CN, et al. Among authors: sundar sn. Mol Biol Cell. 2010 Apr 1;21(7):1166-77. doi: 10.1091/mbc.e09-08-0689. Epub 2010 Feb 3. Mol Biol Cell. 2010. PMID: 20130088 Free PMC article.
Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition of estrogen receptor-alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates the G1 cell cycle arrest of human breast cancer cells.
Marconett CN, Sundar SN, Tseng M, Tin AS, Tran KQ, Mahuron KM, Bjeldanes LF, Firestone GL. Marconett CN, et al. Among authors: sundar sn. Carcinogenesis. 2011 Sep;32(9):1315-23. doi: 10.1093/carcin/bgr116. Epub 2011 Jun 21. Carcinogenesis. 2011. PMID: 21693539 Free PMC article.
14 results