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Page 1
Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies.
Acin-Perez R, Benincá C, Fernandez Del Rio L, Shu C, Baghdasarian S, Zanette V, Gerle C, Jiko C, Khairallah R, Khan S, Rincon Fernandez Pacheco D, Shabane B, Erion K, Masand R, Dugar S, Ghenoiu C, Schreiner G, Stiles L, Liesa M, Shirihai OS. Acin-Perez R, et al. Among authors: dugar s. EMBO J. 2023 May 15;42(10):e111699. doi: 10.15252/embj.2022111699. Epub 2023 Mar 13. EMBO J. 2023. PMID: 36912136 Free PMC article.
We find that CV hydrolytic activity takes place in coupled intact mitochondria and is increased by respiratory chain defects. We identified (+)-Epicatechin as a selective inhibitor of ATP hydrolysis that binds CV while preventing the binding of ATPIF1. ...
We find that CV hydrolytic activity takes place in coupled intact mitochondria and is increased by respiratory chain defects. We identified …
11-beta-hydroxysterols as possible endogenous stimulators of mitochondrial biogenesis as inferred from epicatechin molecular mimicry.
Dugar S, Villarreal F, Hollinger FH, Mahajan D, Ramirez-Sanchez I, Moreno-Ulloa A, Ceballos G, Schreiner G. Dugar S, et al. Pharmacol Res. 2020 Jan;151:104540. doi: 10.1016/j.phrs.2019.104540. Epub 2019 Nov 10. Pharmacol Res. 2020. PMID: 31722227
The molecular size of the cacao flavanols (epicatechin and catechin) highly resembles that of sterols and epicatechin has been reported to activate cells surface receptors leading to the stimulation of MB in endothelial and skeletal muscle cells translating i …
The molecular size of the cacao flavanols (epicatechin and catechin) highly resembles that of sterols and epicatechin h …
(-)-Epicatechin induces mitochondrial biogenesis and markers of muscle regeneration in adults with Becker muscular dystrophy.
McDonald CM, Ramirez-Sanchez I, Oskarsson B, Joyce N, Aguilar C, Nicorici A, Dayan J, Goude E, Abresch RT, Villarreal F, Ceballos G, Perkins G, Dugar S, Schreiner G, Henricson EK. McDonald CM, et al. Among authors: dugar s. Muscle Nerve. 2021 Feb;63(2):239-249. doi: 10.1002/mus.27108. Epub 2020 Dec 16. Muscle Nerve. 2021. PMID: 33125736 Free PMC article.
INTRODUCTION: We conducted an open-label study to examine the effects of the flavonoid (-)-epicatechin in seven ambulatory adult patients with Becker muscular dystrophy (BMD). METHODS: Seven participants received (-)-epicatechin 50 mg twice per day for 8 weeks. ...T …
INTRODUCTION: We conducted an open-label study to examine the effects of the flavonoid (-)-epicatechin in seven ambulatory adult pati …
Pharmacokinetic, partial pharmacodynamic and initial safety analysis of (-)-epicatechin in healthy volunteers.
Barnett CF, Moreno-Ulloa A, Shiva S, Ramirez-Sanchez I, Taub PR, Su Y, Ceballos G, Dugar S, Schreiner G, Villarreal F. Barnett CF, et al. Among authors: dugar s. Food Funct. 2015 Mar;6(3):824-33. doi: 10.1039/c4fo00596a. Food Funct. 2015. PMID: 25598082 Free PMC article. Clinical Trial.
(-)-Epicatechin ((-)-EPI), a naturally occurring flavanol, has emerged as a likely candidate for cocoa-based product reported reductions in cardiometabolic risk. ...
(-)-Epicatechin ((-)-EPI), a naturally occurring flavanol, has emerged as a likely candidate for cocoa-based product reported reducti …
Safety and efficacy of (+)-epicatechin in subjects with Friedreich's ataxia: A phase II, open-label, prospective study.
Qureshi MY, Patterson MC, Clark V, Johnson JN, Moutvic MA, Driscoll SW, Kemppainen JL, Huston J 3rd, Anderson JR, Badley AD, Tebben PJ, Wackel P, Oglesbee D, Glockner J, Schreiner G, Dugar S, Touchette JC, Gavrilova RH. Qureshi MY, et al. Among authors: dugar s. J Inherit Metab Dis. 2021 Mar;44(2):502-514. doi: 10.1002/jimd.12285. Epub 2020 Aug 31. J Inherit Metab Dis. 2021. PMID: 32677106 Clinical Trial.
BACKGROUND: (+)-Epicatechin (EPI) induces mitochondrial biogenesis and antioxidant metabolism in muscle fibers and neurons. ...Improvement was observed in cardiac structure and function in subset of subjects with FRDA without statistically significant improvement in primar …
BACKGROUND: (+)-Epicatechin (EPI) induces mitochondrial biogenesis and antioxidant metabolism in muscle fibers and neurons. ...Improv …
Stimulatory effects of (-)-epicatechin and its enantiomer (+)-epicatechin on mouse frontal cortex neurogenesis markers and short-term memory: proof of concept.
Navarrete-Yañez V, Garate-Carrillo A, Ayala M, Rodriguez-Castañeda A, Mendoza-Lorenzo P, Ceballos G, Ordoñez-Razo R, Dugar S, Schreiner G, Villarreal F, Ramirez-Sanchez I. Navarrete-Yañez V, et al. Among authors: dugar s. Food Funct. 2021 Apr 26;12(8):3504-3515. doi: 10.1039/d0fo03084h. Food Funct. 2021. PMID: 33900336
Consumption of (-)-epicatechin (Epi), a cacao flavanol improves cognition. The aim was to compare the effects of (-)-Epi or its stereoisomer (+)-Epi on mouse frontal cortex-dependent short-term working memory and modulators of neurogenesis. ...
Consumption of (-)-epicatechin (Epi), a cacao flavanol improves cognition. The aim was to compare the effects of (-)-Epi or its stere …
A pilot study on clinical pharmacokinetics and preclinical pharmacodynamics of (+)-epicatechin on cardiometabolic endpoints.
Moreno-Ulloa A , Nájera-García N , Hernández M , Ramírez-Sánchez I , Taub PR , Su Y , Beltrán-Partida E , Ceballos G , Dugar S , Schreiner G , Best BM , Ciaraldi TP , Henry RR , Villarreal F . Moreno-Ulloa A , et al. Among authors: dugar s. Food Funct. 2018 Jan 24;9(1):307-319. doi: 10.1039/c7fo01028a. Food Funct. 2018. PMID: 29171848 Free PMC article. Clinical Trial.
We reported that (-)-epicatechin can stimulate mitochondria biogenesis and improve metabolism. However, preliminary studies indicate that the (+) stereoisomer form may be more potent. We evaluated in a preliminary manner, the pharmacokinetics (PK) and initial safety analys …
We reported that (-)-epicatechin can stimulate mitochondria biogenesis and improve metabolism. However, preliminary studies indicate …
A randomized, placebo-controlled, double-blind study on the effects of (-)-epicatechin on the triglyceride/HDLc ratio and cardiometabolic profile of subjects with hypertriglyceridemia: Unique in vitro effects.
Gutiérrez-Salmeán G, Meaney E, Lanaspa MA, Cicerchi C, Johnson RJ, Dugar S, Taub P, Ramírez-Sánchez I, Villarreal F, Schreiner G, Ceballos G. Gutiérrez-Salmeán G, et al. Among authors: dugar s. Int J Cardiol. 2016 Nov 15;223:500-506. doi: 10.1016/j.ijcard.2016.08.158. Epub 2016 Aug 8. Int J Cardiol. 2016. PMID: 27552564 Clinical Trial.
However, they often exhibit poor long-term patient compliance. Nutraceutics, including (-)-epicatechin (EPI), have gained increasing interest as coadjuvant effective and safe therapies that are able to attenuate hypertension, hyperglycemia, hyperinsulinemia, hypertriglycer …
However, they often exhibit poor long-term patient compliance. Nutraceutics, including (-)-epicatechin (EPI), have gained increasing …