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A pilot project to generate affinity reagents to human proteins.
Uhlen M, Gräslund S, Sundström M. Uhlen M, et al. Nat Methods. 2008 Oct;5(10):854-5. doi: 10.1038/nmeth1008-854. Nat Methods. 2008. PMID: 18825127 No abstract available.
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.
Ng SS, Kavanagh KL, McDonough MA, Butler D, Pilka ES, Lienard BM, Bray JE, Savitsky P, Gileadi O, von Delft F, Rose NR, Offer J, Scheinost JC, Borowski T, Sundstrom M, Schofield CJ, Oppermann U. Ng SS, et al. Nature. 2007 Jul 5;448(7149):87-91. doi: 10.1038/nature05971. Epub 2007 Jun 24. Nature. 2007. PMID: 17589501
A genetics-led approach defines the drug target landscape of 30 immune-related traits.
Fang H; ULTRA-DD Consortium, De Wolf H, Knezevic B, Burnham KL, Osgood J, Sanniti A, Lledó Lara A, Kasela S, De Cesco S, Wegner JK, Handunnetthi L, McCann FE, Chen L, Sekine T, Brennan PE, Marsden BD, Damerell D, O'Callaghan CA, Bountra C, Bowness P, Sundström Y, Milani L, Berg L, Göhlmann HW, Peeters PJ, Fairfax BP, Sundström M, Knight JC. Fang H, et al. Among authors: sundstrom m. Nat Genet. 2019 Jul;51(7):1082-1091. doi: 10.1038/s41588-019-0456-1. Epub 2019 Jun 28. Nat Genet. 2019. PMID: 31253980 Free PMC article.
Preclinical target validation using patient-derived cells.
Edwards AM, Arrowsmith CH, Bountra C, Bunnage ME, Feldmann M, Knight JC, Patel DD, Prinos P, Taylor MD, Sundström M; SGC Open Source Target-Discovery Partnership. Edwards AM, et al. Nat Rev Drug Discov. 2015 Mar;14(3):149-50. doi: 10.1038/nrd4565. Epub 2015 Feb 20. Nat Rev Drug Discov. 2015. PMID: 25722227
Structural basis for protein-protein interactions in the 14-3-3 protein family.
Yang X, Lee WH, Sobott F, Papagrigoriou E, Robinson CV, Grossmann JG, Sundström M, Doyle DA, Elkins JM. Yang X, et al. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17237-42. doi: 10.1073/pnas.0605779103. Epub 2006 Nov 3. Proc Natl Acad Sci U S A. 2006. PMID: 17085597 Free PMC article.
Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundström M, Doyle DA, Siderovski DP. Soundararajan M, et al. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6457-62. doi: 10.1073/pnas.0801508105. Epub 2008 Apr 23. Proc Natl Acad Sci U S A. 2008. PMID: 18434541 Free PMC article.
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Fedorov O, Marsden B, Pogacic V, Rellos P, Müller S, Bullock AN, Schwaller J, Sundström M, Knapp S. Fedorov O, et al. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. doi: 10.1073/pnas.0708800104. Epub 2007 Dec 11. Proc Natl Acad Sci U S A. 2007. PMID: 18077363 Free PMC article.
Insights for the development of specific kinase inhibitors by targeted structural genomics.
Fedorov O, Sundström M, Marsden B, Knapp S. Fedorov O, et al. Drug Discov Today. 2007 May;12(9-10):365-72. doi: 10.1016/j.drudis.2007.03.006. Epub 2007 Mar 29. Drug Discov Today. 2007. PMID: 17467572 Review.
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination.
Vedadi M, Niesen FH, Allali-Hassani A, Fedorov OY, Finerty PJ Jr, Wasney GA, Yeung R, Arrowsmith C, Ball LJ, Berglund H, Hui R, Marsden BD, Nordlund P, Sundstrom M, Weigelt J, Edwards AM. Vedadi M, et al. Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15835-40. doi: 10.1073/pnas.0605224103. Epub 2006 Oct 11. Proc Natl Acad Sci U S A. 2006. PMID: 17035505 Free PMC article.
The promise and peril of chemical probes.
Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, Cravatt B, Dahlin JL, Dhanak D, Edwards AM, Frederiksen M, Frye SV, Gray N, Grimshaw CE, Hepworth D, Howe T, Huber KV, Jin J, Knapp S, Kotz JD, Kruger RG, Lowe D, Mader MM, Marsden B, Mueller-Fahrnow A, Müller S, O'Hagan RC, Overington JP, Owen DR, Rosenberg SH, Roth B, Ross R, Schapira M, Schreiber SL, Shoichet B, Sundström M, Superti-Furga G, Taunton J, Toledo-Sherman L, Walpole C, Walters MA, Willson TM, Workman P, Young RN, Zuercher WJ. Arrowsmith CH, et al. Nat Chem Biol. 2015 Aug;11(8):536-41. doi: 10.1038/nchembio.1867. Nat Chem Biol. 2015. PMID: 26196764 Free PMC article.
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