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Suppressor of cytokine signalling 1 in lymphocytes regulates the development of intestinal inflammation in mice.
Inagaki-Ohara K, Sasaki A, Matsuzaki G, Ikeda T, Hotokezaka M, Chijiiwa K, Kubo M, Yoshida H, Nawa Y, Yoshimura A. Inagaki-Ohara K, et al. Gut. 2006 Feb;55(2):212-9. doi: 10.1136/gut.2004.062653. Epub 2005 Aug 24. Gut. 2006. PMID: 16120757 Free PMC article.
However, the importance of regulation of cytokine signalling in IBD has not been fully clarified. We have demonstrated that suppressor of cytokine signalling 1 (SOCS1) is expressed in inflamed tissues in an experimental colitis mod …
However, the importance of regulation of cytokine signalling in IBD has not been fully clarified. We have demonstrated …
LKB1 deficiency in T cells promotes the development of gastrointestinal polyposis.
Poffenberger MC, Metcalfe-Roach A, Aguilar E, Chen J, Hsu BE, Wong AH, Johnson RM, Flynn B, Samborska B, Ma EH, Gravel SP, Tonelli L, Devorkin L, Kim P, Hall A, Izreig S, Loginicheva E, Beauchemin N, Siegel PM, Artyomov MN, Lum JJ, Zogopoulos G, Blagih J, Jones RG. Poffenberger MC, et al. Science. 2018 Jul 27;361(6400):406-411. doi: 10.1126/science.aan3975. Science. 2018. PMID: 30049881
Here, we report that heterozygous deletion of Stk11 in T cells (LT(het) mice) is sufficient to promote GI polyposis. Polyps from LT(het) mice, Stk11(+/-) mice, and human PJS patients display hallmarks of chronic inflammation, marked by inflammatory imm …
Here, we report that heterozygous deletion of Stk11 in T cells (LT(het) mice) is sufficient to promote GI polyposis. Polyps from LT(h …
Adenomatous Polyposis Coli Defines Treg Differentiation and Anti-inflammatory Function through Microtubule-Mediated NFAT Localization.
Agüera-González S, Burton OT, Vázquez-Chávez E, Cuche C, Herit F, Bouchet J, Lasserre R, Del Río-Iñiguez I, Di Bartolo V, Alcover A. Agüera-González S, et al. Cell Rep. 2017 Oct 3;21(1):181-194. doi: 10.1016/j.celrep.2017.09.020. Cell Rep. 2017. PMID: 28978472 Free article.
Adenomatous polyposis coli (APC) is a polarity regulator and tumor suppressor associated with familial adenomatous polyposis and colorectal cancer development. ...These findings suggest a dual role for APC mutations in colorectal cancer development, wh …
Adenomatous polyposis coli (APC) is a polarity regulator and tumor suppressor associated with familial adenomatous polyposis a …
Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells.
Rutz S, Kayagaki N, Phung QT, Eidenschenk C, Noubade R, Wang X, Lesch J, Lu R, Newton K, Huang OW, Cochran AG, Vasser M, Fauber BP, DeVoss J, Webster J, Diehl L, Modrusan Z, Kirkpatrick DS, Lill JR, Ouyang W, Dixit VM. Rutz S, et al. Nature. 2015 Feb 19;518(7539):417-21. doi: 10.1038/nature13979. Epub 2014 Dec 3. Nature. 2015. PMID: 25470037
Here we show that the deubiquitylating enzyme DUBA is a negative regulator of IL-17A production in T cells. Mice with DUBA-deficient T cells developed exacerbated inflammation in the small intestine after challenge with anti-CD3 antibodies. ...D …
Here we show that the deubiquitylating enzyme DUBA is a negative regulator of IL-17A production in T cells. Mice with DUBA-def …
Helicobacter pylori infection promotes methylation and silencing of trefoil factor 2, leading to gastric tumor development in mice and humans.
Peterson AJ, Menheniott TR, O'Connor L, Walduck AK, Fox JG, Kawakami K, Minamoto T, Ong EK, Wang TC, Judd LM, Giraud AS. Peterson AJ, et al. Gastroenterology. 2010 Dec;139(6):2005-17. doi: 10.1053/j.gastro.2010.08.043. Epub 2010 Aug 27. Gastroenterology. 2010. PMID: 20801119 Free PMC article.
Genome demethylation restored TFF2 expression in gastric cancer cell lines, so TFF2 silencing requires methylation. In Tff2-deficient gp130(F/F)/Tff2(-/-) mice, proliferation of mucosal cells and release of T helper cell type-1 (Th-1) 1 cytokines
Genome demethylation restored TFF2 expression in gastric cancer cell lines, so TFF2 silencing requires methylation. In Tff2-deficient gp130( …
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