A feud that wasn't: acetylcholine evokes dopamine release in the striatum

D James Surmeier; Ann M Graybiel

doi:10.1016/j.neuron.2012.06.028

A feud that wasn't: acetylcholine evokes dopamine release in the striatum

Neuron. 2012 Jul 12;75(1):1-3. doi: 10.1016/j.neuron.2012.06.028.

Authors

D James Surmeier¹, Ann M Graybiel

Affiliation

¹ Department of Physiology, Feinberg College of Medicine, Northwestern University, Chicago, IL 60611, USA. j-surmeier@northwestern.edu

Abstract

In this issue of Neuron, Threlfell et al. (2012) report that synchronous activation of cholinergic interneurons evokes striatal dopamine release by activating presynaptic nicotinic acetylcholine receptors. These findings call for a fundamental reevaluation of the long-standing view that dopamine and acetylcholine "feud" over control of striatal circuitry.

Publication types

Comment

Grants and funding

R01 NS034696/NS/NINDS NIH HHS/United States