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Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum.
Surolia N, Surolia A. Surolia N, et al. Among authors: surolia a. Nat Med. 2001 Feb;7(2):167-73. doi: 10.1038/84612. Nat Med. 2001. PMID: 11175846
The antimicrobial biocide triclosan [5-chloro-2-(2,4-dichlorophenoxy)phenol] potently inhibits the growth of Plasmodium falciparum in vitro and, in a mouse model, Plasmodium berghei in vivo. ...We establish the existence of the de novo fatty acid biosynthetic pathway in th …
The antimicrobial biocide triclosan [5-chloro-2-(2,4-dichlorophenoxy)phenol] potently inhibits the growth of Plasmodium falciparum in vitro …
A novel mode of carbohydrate recognition in jacalin, a Moraceae plant lectin with a beta-prism fold.
Sankaranarayanan R, Sekar K, Banerjee R, Sharma V, Surolia A, Vijayan M. Sankaranarayanan R, et al. Among authors: surolia a. Nat Struct Biol. 1996 Jul;3(7):596-603. doi: 10.1038/nsb0796-596. Nat Struct Biol. 1996. PMID: 8673603
Jacalin, a tetrameric two-chain lectin (66,000 Mr) from jackfruit seeds, is highly specific for the tumour associated T-antigenic disaccharide. ...The lectin exhibits a novel carbohydrate-binding site involving the N terminus of the alpha-chain which is generated th …
Jacalin, a tetrameric two-chain lectin (66,000 Mr) from jackfruit seeds, is highly specific for the tumour associated T-antigenic dis …
Surface plasmon resonance studies resolve the enigmatic endotoxin neutralizing activity of polymyxin B.
Thomas CJ, Surolia N, Surolia A. Thomas CJ, et al. Among authors: surolia n, surolia a. J Biol Chem. 1999 Oct 15;274(42):29624-7. doi: 10.1074/jbc.274.42.29624. J Biol Chem. 1999. PMID: 10514430
Polymyxin B (PMB), a cyclic cationic peptide antibiotic, despite its severe side effects continues to occupy a premiere position for treating endotoxicosis. ...These studies thus provide a striking illustration of the difference in the behavior of PMB, vis …
Polymyxin B (PMB), a cyclic cationic peptide antibiotic, despite its severe side effects continues to occupy a premiere positi …
Structural basis for triclosan and NAD binding to enoyl-ACP reductase of Plasmodium falciparum.
Suguna K, Surolia A, Surolia N. Suguna K, et al. Among authors: surolia a, surolia n. Biochem Biophys Res Commun. 2001 Apr 27;283(1):224-8. doi: 10.1006/bbrc.2001.4747. Biochem Biophys Res Commun. 2001. PMID: 11322792
Recent discovery of type II fatty acid synthase in the malarial parasite Plasmodium falciparum responsible for the most debilitating form of the disease in humans makes it ideal as a target for the development of novel antimalarials. ...In the studies reported here, a
Recent discovery of type II fatty acid synthase in the malarial parasite Plasmodium falciparum responsible for the most debilitating form of …
Kinetic and thermodynamic analysis of the interactions of 23-residue peptides with endotoxin.
Thomas CJ, Surolia N, Surolia A. Thomas CJ, et al. Among authors: surolia n, surolia a. J Biol Chem. 2001 Sep 21;276(38):35701-6. doi: 10.1074/jbc.M011319200. Epub 2001 May 30. J Biol Chem. 2001. PMID: 11384964
In this work we describe the endotoxin binding properties of a series of 23-residue peptides based on the sequence corresponding to the antisense strand of the magainin gene. ...Three of the seven peptides tested have high affinities for endotoxin that approach the values …
In this work we describe the endotoxin binding properties of a series of 23-residue peptides based on the sequence corresponding to t …
Kinetic determinants of the interaction of enoyl-ACP reductase from Plasmodium falciparum with its substrates and inhibitors.
Kapoor M, Dar MJ, Surolia A, Surolia N. Kapoor M, et al. Among authors: surolia a, surolia n. Biochem Biophys Res Commun. 2001 Dec 14;289(4):832-7. doi: 10.1006/bbrc.2001.6061. Biochem Biophys Res Commun. 2001. PMID: 11735121
Paradigm shifts in malaria parasite biochemistry and anti-malarial chemotherapy.
Surolia N, RamachandraRao SP, Surolia A. Surolia N, et al. Among authors: surolia a. Bioessays. 2002 Feb;24(2):192-6. doi: 10.1002/bies.10042. Bioessays. 2002. PMID: 11835284
A fatty acid synthesis (FAS) pathway was recently discovered and established in the obligate human parasite Plasmodium falciparum. Its inhibition by triclosan (2,4,4'-trichloro-2'-hydroxydiphenyl ether) leads to its classification as a type II FAS. Humans, the verte
A fatty acid synthesis (FAS) pathway was recently discovered and established in the obligate human parasite Plasmodium falciparum. It
Exploring the interaction energies for the binding of hydroxydiphenyl ethers to enoyl-acyl carrier protein reductases.
Muralidharan J, Suguna K, Surolia A, Surolia N. Muralidharan J, et al. Among authors: surolia a, surolia n. J Biomol Struct Dyn. 2003 Feb;20(4):589-94. doi: 10.1080/07391102.2003.10506875. J Biomol Struct Dyn. 2003. PMID: 12529157
Existence of a high degree of similarity between the recently discovered enoyl-ACP reductase from P. falciparum and B. napus enzyme permitted building of a satisfactory model for the former enzyme that explained some of the key aspects of the enzyme such as its spec …
Existence of a high degree of similarity between the recently discovered enoyl-ACP reductase from P. falciparum and B. napus enzyme p …
Identification, characterization, and inhibition of Plasmodium falciparum beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ).
Sharma SK, Kapoor M, Ramya TN, Kumar S, Kumar G, Modak R, Sharma S, Surolia N, Surolia A. Sharma SK, et al. Among authors: surolia n, surolia a. J Biol Chem. 2003 Nov 14;278(46):45661-71. doi: 10.1074/jbc.M304283200. Epub 2003 Aug 20. J Biol Chem. 2003. PMID: 12930838
In this context, the fatty acid biosynthesis (FAS) pathway of the malarial parasite has recently received a lot of attention. ...We modeled the structure of PfFabZ using Escherichia coli beta-hydroxydecanoyl thioester dehydratase (EcFabA) as a template. ...
In this context, the fatty acid biosynthesis (FAS) pathway of the malarial parasite has recently received a lot of attention. ...We m …
Triclosan: a shot in the arm for antimalarial chemotherapy.
Rao SP, Surolia A, Surolia N. Rao SP, et al. Among authors: surolia a, surolia n. Mol Cell Biochem. 2003 Nov;253(1-2):55-63. doi: 10.1023/a:1026049217966. Mol Cell Biochem. 2003. PMID: 14619956 Review.
In order that malaria be successfully contained, it is important that one has a clear understanding of the normal physiology and biochemistry of the parasite essential to its survival in its human host. ...How triclosan could tilt the balance in favor of the human hosts of …
In order that malaria be successfully contained, it is important that one has a clear understanding of the normal physiology and bioc …
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