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Comparison of bifunctional chelates for (64)Cu antibody imaging.
Ferreira CL, Yapp DT, Crisp S, Sutherland BW, Ng SS, Gleave M, Bensimon C, Jurek P, Kiefer GE. Ferreira CL, et al. Among authors: sutherland bw. Eur J Nucl Med Mol Imaging. 2010 Nov;37(11):2117-26. doi: 10.1007/s00259-010-1506-1. Epub 2010 Jun 16. Eur J Nucl Med Mol Imaging. 2010. PMID: 20552190
QLT0267, a small molecule inhibitor targeting integrin-linked kinase (ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatment outcomes in an orthotopic breast cancer model.
Kalra J, Warburton C, Fang K, Edwards L, Daynard T, Waterhouse D, Dragowska W, Sutherland BW, Dedhar S, Gelmon K, Bally M. Kalra J, et al. Among authors: sutherland bw. Breast Cancer Res. 2009;11(3):R25. doi: 10.1186/bcr2252. Epub 2009 May 1. Breast Cancer Res. 2009. PMID: 19409087 Free PMC article.
Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells.
Sutherland BW, Kucab J, Wu J, Lee C, Cheang MC, Yorida E, Turbin D, Dedhar S, Nelson C, Pollak M, Leighton Grimes H, Miller K, Badve S, Huntsman D, Blake-Gilks C, Chen M, Pallen CJ, Dunn SE. Sutherland BW, et al. Oncogene. 2005 Jun 16;24(26):4281-92. doi: 10.1038/sj.onc.1208590. Oncogene. 2005. PMID: 15806160
Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors.
Lou Y, McDonald PC, Oloumi A, Chia S, Ostlund C, Ahmadi A, Kyle A, Auf dem Keller U, Leung S, Huntsman D, Clarke B, Sutherland BW, Waterhouse D, Bally M, Roskelley C, Overall CM, Minchinton A, Pacchiano F, Carta F, Scozzafava A, Touisni N, Winum JY, Supuran CT, Dedhar S. Lou Y, et al. Among authors: sutherland bw. Cancer Res. 2011 May 1;71(9):3364-76. doi: 10.1158/0008-5472.CAN-10-4261. Epub 2011 Mar 17. Cancer Res. 2011. PMID: 21415165
20 results