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The Cdk-activating kinase (CAK) from budding yeast.
Kaldis P, Sutton A, Solomon MJ. Kaldis P, et al. Cell. 1996 Aug 23;86(4):553-64. doi: 10.1016/s0092-8674(00)80129-4. Cell. 1996. PMID: 8752210
Unlike CAKs from other organisms, Cak1p is active as a monomer, has full activity when expressed in E. coli, and is not a component of the basal transcription factor, TFIIH. A temperature-sensitive mutation in CAK1 confers a G2 delay accompanied by low …
Unlike CAKs from other organisms, Cak1p is active as a monomer, has full activity when expressed in E. coli, and is not a comp …
The Cak1p protein kinase is required at G1/S and G2/M in the budding yeast cell cycle.
Sutton A, Freiman R. Sutton A, et al. Genetics. 1997 Sep;147(1):57-71. Genetics. 1997. PMID: 9286668 Free PMC article.
Here we describe the isolation of a mutant allele of CAK1 in a synthetic lethal screen with the Sit4 protein phosphatase. Analysis of several different cak1 mutants shows that although the G2 to M transition appears most sensitive to loss of Cak1p function, Cak1p is …
Here we describe the isolation of a mutant allele of CAK1 in a synthetic lethal screen with the Sit4 protein phosphatase. Anal …
The yeast SAS (something about silencing) protein complex contains a MYST-type putative acetyltransferase and functions with chromatin assembly factor ASF1.
Osada S, Sutton A, Muster N, Brown CE, Yates JR 3rd, Sternglanz R, Workman JL. Osada S, et al. Genes Dev. 2001 Dec 1;15(23):3155-68. doi: 10.1101/gad.907201. Genes Dev. 2001. PMID: 11731479 Free PMC article.
The something about silencing (Sas) 2 protein of Saccharomyces cerevisiae, a member of the MYST (MOZ, Ybf2/Sas3, Sas2, and TIP60) acetyltransferase family, promotes silencing at HML and telomeres. Here we identify a ~450-kD SAS complex containing Sas2p, Sas4p, and t …
The something about silencing (Sas) 2 protein of Saccharomyces cerevisiae, a member of the MYST (MOZ, Ybf2/Sas3, Sas2, and TIP60) ace …
Characterization of SIS1, a Saccharomyces cerevisiae homologue of bacterial dnaJ proteins.
Luke MM, Sutton A, Arndt KT. Luke MM, et al. J Cell Biol. 1991 Aug;114(4):623-38. doi: 10.1083/jcb.114.4.623. J Cell Biol. 1991. PMID: 1714460 Free PMC article.
The Saccharomyces cerevisiae SIS1 gene was identified as a high copy number suppressor of the slow growth phenotype of strains containing mutations in the SIT4 gene, which encodes a predicted serine/threonine protein phosphatase. ...This region of SIS1 contains a
The Saccharomyces cerevisiae SIS1 gene was identified as a high copy number suppressor of the slow growth phenotype of strains contai …
Phosphorylation of Cdc28 and regulation of cell size by the protein kinase CKII in Saccharomyces cerevisiae.
Russo GL, van den Bos C, Sutton A, Coccetti P, Baroni MD, Alberghina L, Marshak DR. Russo GL, et al. Biochem J. 2000 Oct 1;351(Pt 1):143-50. doi: 10.1042/0264-6021:3510143. Biochem J. 2000. PMID: 10998356 Free PMC article.
To identify a functional role for this phosphorylation, we have studied the homologous enzymes in the budding yeast Saccharomyces cerevisiae. The S. cerevisiae homologue of Cdc2, Cdc28, contains a consensus CKII site (Ser-46), which is homologous with that of human …
To identify a functional role for this phosphorylation, we have studied the homologous enzymes in the budding yeast Saccharomyces cer …
SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis.
Vaquero A, Scher MB, Lee DH, Sutton A, Cheng HL, Alt FW, Serrano L, Sternglanz R, Reinberg D. Vaquero A, et al. Genes Dev. 2006 May 15;20(10):1256-61. doi: 10.1101/gad.1412706. Epub 2006 Apr 28. Genes Dev. 2006. PMID: 16648462 Free PMC article.
We found that SirT2 and its yeast counterpart Hst2 have a strong preference for histone H4K16Ac in their deacetylation activity in vitro and in vivo. ...Thus, SirT2 is a major contributor to this enzymatic conversion at the time in the cell's life cycle when condens …
We found that SirT2 and its yeast counterpart Hst2 have a strong preference for histone H4K16Ac in their deacetylation activity in vi …
Enp1, a yeast protein associated with U3 and U14 snoRNAs, is required for pre-rRNA processing and 40S subunit synthesis.
Chen W, Bucaria J, Band DA, Sutton A, Sternglanz R. Chen W, et al. Nucleic Acids Res. 2003 Jan 15;31(2):690-9. doi: 10.1093/nar/gkg145. Nucleic Acids Res. 2003. PMID: 12527778 Free PMC article.
An enp1-1 temperature-sensitive mutant inhibited 35S pre-rRNA early processing at sites A(0), A(1) and A(2) as shown by northern analysis of steady state levels of rRNA precursors. ...These results suggest a direct role for Enp1 in the early steps of r …
An enp1-1 temperature-sensitive mutant inhibited 35S pre-rRNA early processing at sites A(0), A(1) and A(2) as shown by …
Sas4 and Sas5 are required for the histone acetyltransferase activity of Sas2 in the SAS complex.
Sutton A, Shia WJ, Band D, Kaufman PD, Osada S, Workman JL, Sternglanz R. Sutton A, et al. J Biol Chem. 2003 May 9;278(19):16887-92. doi: 10.1074/jbc.M210709200. Epub 2003 Mar 6. J Biol Chem. 2003. PMID: 12626510
Based on its primary sequence, the Sas2 protein is predicted to be a member of the MYST family of histone acetyltransferases (HATs). Sas2 forms a complex with Sas4 and Sas5, which are required for its silencing function. Here we show that recombinant Sas2 has HAT ac …
Based on its primary sequence, the Sas2 protein is predicted to be a member of the MYST family of histone acetyltransferases (HATs). …
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases.
Landry J, Sutton A, Tafrov ST, Heller RC, Stebbins J, Pillus L, Sternglanz R. Landry J, et al. Proc Natl Acad Sci U S A. 2000 May 23;97(11):5807-11. doi: 10.1073/pnas.110148297. Proc Natl Acad Sci U S A. 2000. PMID: 10811920 Free PMC article.
Considering the far-ranging nature of these functions, a major experimental goal has been to understand the molecular mechanism(s) by which this family of proteins acts. ...Contrary to a recent report, we find no evidence that these proteins ADP-ribosylate histones. …
Considering the far-ranging nature of these functions, a major experimental goal has been to understand the molecular mechanism(s) by …
A novel form of transcriptional silencing by Sum1-1 requires Hst1 and the origin recognition complex.
Sutton A, Heller RC, Landry J, Choy JS, Sirko A, Sternglanz R. Sutton A, et al. Mol Cell Biol. 2001 May;21(10):3514-22. doi: 10.1128/MCB.21.10.3514-3522.2001. Mol Cell Biol. 2001. PMID: 11313477 Free PMC article.
In the yeast Saccharomyces cerevisiae, a and alpha mating-type information is stored in transcriptionally silenced cassettes called HML and HMR. Silencing of these loci, maintained by the formation of a specialized type of heterochromatin, requires trans-acting prot …
In the yeast Saccharomyces cerevisiae, a and alpha mating-type information is stored in transcriptionally silenced cassettes called H …
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