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Regulated protein-protein interaction between aPKC and PAR-3 plays an essential role in the polarization of epithelial cells.
Nagai-Tamai Y, Mizuno K, Hirose T, Suzuki A, Ohno S. Nagai-Tamai Y, et al. Among authors: suzuki a. Genes Cells. 2002 Nov;7(11):1161-71. doi: 10.1046/j.1365-2443.2002.00590.x. Genes Cells. 2002. PMID: 12390250
Over-expression of a point mutant of PAR-3 (S827A), which is predicted to form a stable complex with aPKC, causes defects in the cell-cell contact-induced cell polarization of epithelial MDCK cells, similarly to a dominant negative mutant of aPKC. CONCLUSIONS …
Over-expression of a point mutant of PAR-3 (S827A), which is predicted to form a stable complex with aPKC, causes defects in t …
Specific intron-dependent loading of DAZAP1 onto the cox6c transcript suppresses pre-mRNA splicing efficacy and induces cell growth retardation.
Sasaki K, Ono M, Takabe K, Suzuki A, Kurihara Y. Sasaki K, et al. Among authors: suzuki a. Gene. 2018 May 30;657:1-8. doi: 10.1016/j.gene.2018.03.005. Epub 2018 Mar 2. Gene. 2018. PMID: 29505834
DAZAP1-knockout mice carrying a partial loss-of-function (hypomorphic) allele exhibited severe deficiencies in spermatogenesis and cell growth, indicating that DAZAP1 plays a pivotal role in the development of germ and somatic cells. We have identified cox6c mRNA, w …
DAZAP1-knockout mice carrying a partial loss-of-function (hypomorphic) allele exhibited severe deficiencies in spermatogenesis and ce …
Maintenance of dendritic spine morphology by partitioning-defective 1b through regulation of microtubule growth.
Hayashi K, Suzuki A, Hirai S, Kurihara Y, Hoogenraad CC, Ohno S. Hayashi K, et al. Among authors: suzuki a. J Neurosci. 2011 Aug 24;31(34):12094-103. doi: 10.1523/JNEUROSCI.0751-11.2011. J Neurosci. 2011. PMID: 21865452 Free PMC article.
Partitioning-defective 1b (PAR1b), a cell polarity-regulating serine/threonine protein kinase, is thought to regulate microtubule dynamics by inhibiting microtubule binding of microtubule-associated proteins. ...In conclusion, the present results suggested a novel f …
Partitioning-defective 1b (PAR1b), a cell polarity-regulating serine/threonine protein kinase, is thought to regulate microtubule dyn …
Structural basis for compound C inhibition of the human AMP-activated protein kinase α2 subunit kinase domain.
Handa N, Takagi T, Saijo S, Kishishita S, Takaya D, Toyama M, Terada T, Shirouzu M, Suzuki A, Lee S, Yamauchi T, Okada-Iwabu M, Iwabu M, Kadowaki T, Minokoshi Y, Yokoyama S. Handa N, et al. Among authors: suzuki a. Acta Crystallogr D Biol Crystallogr. 2011 May;67(Pt 5):480-7. doi: 10.1107/S0907444911010201. Epub 2011 Apr 14. Acta Crystallogr D Biol Crystallogr. 2011. PMID: 21543851
AMP-activated protein kinase (AMPK) is a serine/threonine kinase that functions as a sensor to maintain energy balance at both the cellular and the whole-body levels and is therefore a potential target for drug design against metabolic syndrome, obesity and t …
AMP-activated protein kinase (AMPK) is a serine/threonine kinase that functions as a sensor to maintain energy balance at both …
Crystal structure of the Ca²⁺/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609.
Kukimoto-Niino M, Yoshikawa S, Takagi T, Ohsawa N, Tomabechi Y, Terada T, Shirouzu M, Suzuki A, Lee S, Yamauchi T, Okada-Iwabu M, Iwabu M, Kadowaki T, Minokoshi Y, Yokoyama S. Kukimoto-Niino M, et al. Among authors: suzuki a. J Biol Chem. 2011 Jun 24;286(25):22570-9. doi: 10.1074/jbc.M111.251710. Epub 2011 Apr 19. J Biol Chem. 2011. PMID: 21504895 Free PMC article.
Ca(2+)/calmodulin (CaM)-dependent protein kinase (CaMK) kinase (CaMKK) is a member of the CaMK cascade that mediates the response to intracellular Ca(2+) elevation. ...The structure revealed that CaMKKβ lacks the αD helix and that the equivalent region displays a hy …
Ca(2+)/calmodulin (CaM)-dependent protein kinase (CaMK) kinase (CaMKK) is a member of the CaMK cascade that mediates the response to …
Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein.
Suzuki A, Kusakai G, Kishimoto A, Lu J, Ogura T, Lavin MF, Esumi H. Suzuki A, et al. J Biol Chem. 2003 Jan 3;278(1):48-53. doi: 10.1074/jbc.M206025200. Epub 2002 Oct 29. J Biol Chem. 2003. PMID: 12409306
We identified a novel human AMP-activated protein kinase (AMPK) family member, designated ARK5, encoding 661 amino acids with an estimated molecular mass of 74 kDa. ...It has a putative Akt phosphorylation motif at amino acids 595-600, and Ser(600) was found to be p …
We identified a novel human AMP-activated protein kinase (AMPK) family member, designated ARK5, encoding 661 amino acids with an esti …
Self-association of PAR-3-mediated by the conserved N-terminal domain contributes to the development of epithelial tight junctions.
Mizuno K, Suzuki A, Hirose T, Kitamura K, Kutsuzawa K, Futaki M, Amano Y, Ohno S. Mizuno K, et al. Among authors: suzuki a. J Biol Chem. 2003 Aug 15;278(33):31240-50. doi: 10.1074/jbc.M303593200. Epub 2003 May 19. J Biol Chem. 2003. PMID: 12756256
PAR-3 is a scaffold-like PDZ-containing protein that forms a complex with PAR-6 and atypical protein kinase C (PAR-3-atypical protein kinase C-PAR-6 complex) and contributes to the establishment of cell polarity in a wide variety of biological contexts. ...Th …
PAR-3 is a scaffold-like PDZ-containing protein that forms a complex with PAR-6 and atypical protein kinase C (PAR-3-atypical …
The gamma-parvin-integrin-linked kinase complex is critically involved in leukocyte-substrate interaction.
Yoshimi R, Yamaji S, Suzuki A, Mishima W, Okamura M, Obana T, Matsuda C, Miwa Y, Ohno S, Ishigatsubo Y. Yoshimi R, et al. Among authors: suzuki a. J Immunol. 2006 Mar 15;176(6):3611-24. doi: 10.4049/jimmunol.176.6.3611. J Immunol. 2006. PMID: 16517730
In this study, we demonstrate that gamma-parvin, one of three mammalian parvin family members, is specifically expressed in several lymphoid and monocytic cell lines in a complementary manner to affixin. ...Taken together with the results that gamma-parvin could form a
In this study, we demonstrate that gamma-parvin, one of three mammalian parvin family members, is specifically expressed in several lymphoid …
PAR-1/MARK: a kinase essential for maintaining the dynamic state of microtubules.
Hayashi K, Suzuki A, Ohno S. Hayashi K, et al. Among authors: suzuki a. Cell Struct Funct. 2012;37(1):21-5. doi: 10.1247/csf.11038. Epub 2011 Dec 3. Cell Struct Funct. 2012. PMID: 22139392 Review.
The serine/threonine kinase, PAR-1, is an essential component of the evolutionary-conserved polarity-regulating system, PAR-aPKC system, which plays indispensable roles in establishing asymmetric protein distributions and cell polarity in various biological contexts (Suzuki
The serine/threonine kinase, PAR-1, is an essential component of the evolutionary-conserved polarity-regulating system, PAR-aPKC system, whi …
Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells.
Horikoshi Y, Suzuki A, Yamanaka T, Sasaki K, Mizuno K, Sawada H, Yonemura S, Ohno S. Horikoshi Y, et al. Among authors: suzuki a. J Cell Sci. 2009 May 15;122(Pt 10):1595-606. doi: 10.1242/jcs.043174. Epub 2009 Apr 28. J Cell Sci. 2009. PMID: 19401335
The defects in PAR-3 knockdown cells are efficiently rescued by wild-type PAR-3, but not by a point mutant (S827/829A) that lacks the ability to interact with aPKC, indicating that formation of the PAR-3-aPKC-PAR-6 complex is essential for apical membrane development. ...
The defects in PAR-3 knockdown cells are efficiently rescued by wild-type PAR-3, but not by a point mutant (S827/829A) that lacks the …
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