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Sequential operation of ceramide synthesis and ICE cascade in CPT-11-initiated apoptotic death signaling.
Suzuki A, Iwasaki M, Kato M, Wagai N. Suzuki A, et al. Exp Cell Res. 1997 May 25;233(1):41-7. doi: 10.1006/excr.1997.3498. Exp Cell Res. 1997. PMID: 9184074
These results suggest that ceramide synthesis acts as a dominant regulator in CPT-11-initiated death signaling and sequentially operates the ICE cascade....
These results suggest that ceramide synthesis acts as a dominant regulator in CPT-11-initiated death signaling and sequentially opera …
Involvement of EAT/mcl-1, an anti-apoptotic bcl-2-related gene, in murine embryogenesis and human development.
Sano M, Umezawa A, Suzuki A, Shimoda K, Fukuma M, Hata J. Sano M, et al. Exp Cell Res. 2000 Aug 25;259(1):127-39. doi: 10.1006/excr.2000.4977. Exp Cell Res. 2000. PMID: 10942585
EAT/mcl-1 (EAT), an anti-apoptotic bcl-2-related gene, was isolated during the early differentiation of a human embryonal carcinoma cell line, an event which serves as a model of early embryogenesis. ...
EAT/mcl-1 (EAT), an anti-apoptotic bcl-2-related gene, was isolated during the early differentiation of a human embryonal carcinoma c …
Involvement of cytoplasmic serine proteinase and CPP32 subfamily in the molecular machinery of caspase 3 activation during Fas-mediated apoptosis.
Suzuki A, Iwasaki M, Wagai N. Suzuki A, et al. Exp Cell Res. 1997 May 25;233(1):48-55. doi: 10.1006/excr.1997.3546. Exp Cell Res. 1997. PMID: 9184075
The results showed that Fas-mediated apoptosis was accompanied by caspase 3 activation, and both Fas-mediated apoptosis and caspase 3 activation were prevented by a serine proteinase inhibitor. ...These results strongly suggest that a cytoplasmic S. aureus V8-like s …
The results showed that Fas-mediated apoptosis was accompanied by caspase 3 activation, and both Fas-mediated apoptosis and caspase 3 activa …
Down regulation of Bcl-2 is the first step on Fas-mediated apoptosis of male reproductive tract.
Suzuki A, Matsuzawa A, Iguchi T. Suzuki A, et al. Oncogene. 1996 Jul 4;13(1):31-7. Oncogene. 1996. PMID: 8700551
We propose here that apoptotic death signal transduction in total involve, a number of steps, the first and most important of which is down regulation of Bcl-2....
We propose here that apoptotic death signal transduction in total involve, a number of steps, the first and most important of which i …
Necessity of interleukin-1beta converting enzyme cascade in taxotere-initiated death signaling.
Suzuki A, Kawabata T, Kato M. Suzuki A, et al. Eur J Pharmacol. 1998 Feb 5;343(1):87-92. doi: 10.1016/s0014-2999(97)01520-3. Eur J Pharmacol. 1998. PMID: 9551718
Taxotere is a new type chemotherapeutic agent which targets tubulin. In the present study, we investigated the molecular machinery of taxotere-initiated death signaling. ...
Taxotere is a new type chemotherapeutic agent which targets tubulin. In the present study, we investigated the molecular machinery of …
Hepatocyte growth factor promotes cell survival from fas-mediated cell death in hepatocellular carcinoma cells via Akt activation and Fas-death-inducing signaling complex suppression.
Suzuki A, Hayashida M, Kawano H, Sugimoto K, Nakano T, Shiraki K. Suzuki A, et al. Hepatology. 2000 Oct;32(4 Pt 1):796-802. doi: 10.1053/jhep.2000.17738. Hepatology. 2000. PMID: 11003625
The Akt/PI-3 kinase pathway is a system essential for cell survival. In the current study, we showed that hepatocyte growth factor (HGF) activates the Akt/PI-3 kinase pathway to suppress Fas-mediated cell death in human hepatocellular carcinoma (HCC; 3 lines; SK-Hep1, HLE, …
The Akt/PI-3 kinase pathway is a system essential for cell survival. In the current study, we showed that hepatocyte growth factor (H …
Tumor cell "dead or alive": caspase and survivin regulate cell death, cell cycle and cell survival.
Suzuki A, Shiraki K. Suzuki A, et al. Histol Histopathol. 2001 Apr;16(2):583-93. doi: 10.14670/HH-16.583. Histol Histopathol. 2001. PMID: 11332714 Review.
Tumor is one of the disease states produced as a result of the disintegrated regulation and is characterized as cells showing an irreversible progression of cell cycle and a resistance to cell death signaling. ...Caspase is a nomenclature referring to ICE/CED …
Tumor is one of the disease states produced as a result of the disintegrated regulation and is characterized as cells showing an irre …
SADS: A new component of Fas-DISC is the accelerator for cell death signaling and is downregulated in patients with colon carcinoma.
Suzuki A, Obata S, Hayashida M, Kawano H, Nakano T, Shiraki K. Suzuki A, et al. Nat Med. 2001 Jan;7(1):88-93. doi: 10.1038/83401. Nat Med. 2001. PMID: 11135621 Retracted.
Here we have identified a new component of Fas-DISC which we call 'small-accelerator for death signaling' (SADS). SADS cDNA encodes a 150 amino acid polypeptide (Mr = 16,700). ...
Here we have identified a new component of Fas-DISC which we call 'small-accelerator for death signaling' (SADS). SADS cDNA encodes …
Cell death induction by CTL: perforin/granzyme B system dominantly acts for cell death induction in human hepatocellular carcinoma cells.
Hayashida M, Kawano H, Nakano T, Shiraki K, Suzuki A. Hayashida M, et al. Proc Soc Exp Biol Med. 2000 Nov;225(2):143-50. doi: 10.1046/j.1525-1373.2000.22518.x. Proc Soc Exp Biol Med. 2000. PMID: 11044257
Procaspase 3/p21 complex formation to resist fas-mediated cell death is initiated as a result of the phosphorylation of p21 by protein kinase A.
Suzuki A, Kawano H, Hayashida M, Hayasaki Y, Tsutomi Y, Akahane K. Suzuki A, et al. Cell Death Differ. 2000 Aug;7(8):721-8. doi: 10.1038/sj.cdd.4400706. Cell Death Differ. 2000. PMID: 10918446
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