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Seco-cyclic phorbol derivatives and their anti-HIV-1 activities.
Huang X, Huang X, Li Q, Ma M, Cui Y, Yang L, Wang H, Luo R, Chen J, Yang J, Lin J, Li D, Zheng Y, Zhang J. Huang X, et al. Chin J Nat Med. 2024 Apr;22(4):365-374. doi: 10.1016/S1875-5364(24)60630-8. Chin J Nat Med. 2024. PMID: 38658099
The efficacy of phorbol esters in binding with PKC is attributed to the presence of oxygen groups at positions C20, C3/C4, and C9 of phorbol. Concurrently, the lipids located at positions C12/C13 are essential for both the anti-HIV-1 activity and the formation of the PKC-l …
The efficacy of phorbol esters in binding with PKC is attributed to the presence of oxygen groups at positions C20, C3/C4, and C9 of …
Pembrolizumab Plus Binimetinib With or Without Chemotherapy for MSS/pMMR Metastatic Colorectal Cancer: Outcomes From KEYNOTE-651 Cohorts A, C, and E.
Chen EX, Kavan P, Tehfe M, Kortmansky JS, Sawyer MB, Chiorean EG, Lieu CH, Polite B, Wong L, Fakih M, Spencer K, Chaves J, Li C, Leconte P, Adelberg D, Kim R. Chen EX, et al. Clin Colorectal Cancer. 2024 Apr 1:S1533-0028(24)00024-0. doi: 10.1016/j.clcc.2024.03.002. Online ahead of print. Clin Colorectal Cancer. 2024. PMID: 38653648
Groundwater hydrochemistry, source identification and health assessment based on self-organizing map in an intensive mining area in Shanxi, China.
Shang Y, Fu C, Zhang W, Li X, Li X. Shang Y, et al. Environ Res. 2024 Apr 21:118934. doi: 10.1016/j.envres.2024.118934. Online ahead of print. Environ Res. 2024. PMID: 38653438
This study utilizes a combined approach of self-organizing maps (SOM) and K-means clustering to investigate the hydrogeochemical sources of shallow groundwater in the Changzhi Basin and the associated human health risks. The results showed that the groundwater chemical cha …
This study utilizes a combined approach of self-organizing maps (SOM) and K-means clustering to investigate the hydrogeochemical sour …
Formerly degenerate seventh zinc finger domain from transcription factor ZNF711 rehabilitated by experimental NMR structure.
Rua AJ, Alexandrescu AT. Rua AJ, et al. bioRxiv [Preprint]. 2024 Apr 10:2024.04.06.588434. doi: 10.1101/2024.04.06.588434. bioRxiv. 2024. PMID: 38645208 Free PMC article. Preprint.
Mutagenesis and pH titration experiments indicate that H26 is not involved in metal binding and that Z7 has a tridentate metal-binding site comprised of only residues C3, C6, and H19. By contrast, an F23H mutation that introduces a histidine in the consensus position forms …
Mutagenesis and pH titration experiments indicate that H26 is not involved in metal binding and that Z7 has a tridentate metal-binding site …
Newly synthesized palladium(II) complexes with dialkyl esters of (S,S)-propylenediamine-N,N'-di-(2,2'-di-(4-hydroxy-benzil))acetic acid: in vitro investigation of biological activities and HSA/DNA binding.
Ćorović K, Stojković DL, Petrović ĐS, Jovičić Milić SS, Đukić MB, Radojević ID, Raković I, Jurišević M, Gajović N, Jovanović M, Marinković J, Jovanović I, Stojanović B. Ćorović K, et al. Dalton Trans. 2024 Apr 22. doi: 10.1039/d4dt00659c. Online ahead of print. Dalton Trans. 2024. PMID: 38644680
Using fluorescence spectroscopy were investigated the interactions of new palladium(II) complexes [PdCl(2)(R(2)-S,S-pddtyr)]; (R = ethyl (C1), propyl (C2), butyl (C3), and pentyl (C4)) with calf thymus human serum albumin (HSA) and DNA (CT-DNA). The high values of the bind …
Using fluorescence spectroscopy were investigated the interactions of new palladium(II) complexes [PdCl(2)(R(2)-S,S-pddtyr)]; (R = ethyl (C1 …
Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.
GBD 2021 Diseases and Injuries Collaborators. GBD 2021 Diseases and Injuries Collaborators. Lancet. 2024 Apr 15:S0140-6736(24)00757-8. doi: 10.1016/S0140-6736(24)00757-8. Online ahead of print. Lancet. 2024. PMID: 38642570
Classical versus Collective Interactions in Asymmetric Trigonal Bipyramidal Alkaline Metal‒Boron Halide Complexes.
Badri Z, Foroutan-Nejad C. Badri Z, et al. Chemistry. 2024 Apr 20:e202400156. doi: 10.1002/chem.202400156. Online ahead of print. Chemistry. 2024. PMID: 38642012
In this work, we extend the newly introduced concept of collective bonding to a series of neutral boron complexes with the general formula M2BX3 (M = Li, Na, and K; X = F, Cl, and Br). Our state-of-the-art ab initio computations suggest that these complexes form trigonal b …
In this work, we extend the newly introduced concept of collective bonding to a series of neutral boron complexes with the general formula M …
The Effect of C2 Muscular Exposure Technique on Radiographic and Clinical Outcomes After C2-T2 Posterior Cervical Fusion.
Levy HA, Pinter ZW, Pumford A, Salmons HI, Townsley S, Katsos K, Reed R, Chen S, Abode-Iyamah K, Deen HG, Clarke M, Bydon M, Fogelson JL, Elder BD, Currier B, Freedman BA, Nassr AN, Karamian BA, Sebastian AS. Levy HA, et al. Clin Spine Surg. 2024 Apr 10. doi: 10.1097/BSD.0000000000001626. Online ahead of print. Clin Spine Surg. 2024. PMID: 38637921
Preoperative to postoperative changes in C2 slope, C2 tilt, C2-C3 segmental lordosis, C2-C3 listhesis, C0-C2 Cobb angle, proximal junctional kyphosis, ADI, C1 lamina-occiput distance, C2 sagittal vertical axis, C2-C7 lordosis, and PROMs at all follow-up intervals di …
Preoperative to postoperative changes in C2 slope, C2 tilt, C2-C3 segmental lordosis, C2-C3 listhesis, C0-C2 Cobb angle, proxi …
Artemyriantholides A-K, guaiane-type sesquiterpenoid dimers from Artemisia myriantha var. pleiocephala and their antihepatoma activity.
Wang MF, Li TZ, Ma YB, Ma WJ, Wang YC, Li FJ, Chen JJ. Wang MF, et al. Phytochemistry. 2024 Apr 16;222:114100. doi: 10.1016/j.phytochem.2024.114100. Online ahead of print. Phytochemistry. 2024. PMID: 38636688
Artemyriantholides A-K (1-11) as well as 14 known compounds (12-25) were isolated from Artemisia myriantha var. pleiocephala (Asteraceae). ...The interaction between compound 5 and MAP2K2 was conducted to give docking score of -9.0 kcal/mol by molecular docking and provide …
Artemyriantholides A-K (1-11) as well as 14 known compounds (12-25) were isolated from Artemisia myriantha var. pleiocephala (Asterac …
4,359 results