Swales K - Search Results

1

CAR, driving into the future.

Swales K, Negishi M. Swales K, et al. Mol Endocrinol. 2004 Jul;18(7):1589-98. doi: 10.1210/me.2003-0397. Epub 2004 Feb 26. Mol Endocrinol. 2004. PMID: 14988430 Review.

2

Novel CAR-mediated mechanism for synergistic activation of two distinct elements within the human cytochrome P450 2B6 gene in HepG2 cells.

Swales K, Kakizaki S, Yamamoto Y, Inoue K, Kobayashi K, Negishi M. Swales K, et al. J Biol Chem. 2005 Feb 4;280(5):3458-66. doi: 10.1074/jbc.M411318200. Epub 2004 Nov 24. J Biol Chem. 2005. PMID: 15563456

3

Relative receptor expression is a determinant in xenobiotic-mediated CYP3A induction in rat and human cells.

Swales K, Plant N, Ayrton A, Hood S, Gibson G. Swales K, et al. Xenobiotica. 2003 Jul;33(7):703-16. doi: 10.1080/0049825031000121626. Xenobiotica. 2003. PMID: 12893520

4

Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man.

Gibson GG, Plant NJ, Swales KE, Ayrton A, El-Sankary W. Gibson GG, et al. Among authors: swales ke. Xenobiotica. 2002 Mar;32(3):165-206. doi: 10.1080/00498250110102674. Xenobiotica. 2002. PMID: 11958559 Review.

5

Pregnane X receptor regulates drug metabolism and transport in the vasculature and protects from oxidative stress.

Swales KE, Moore R, Truss NJ, Tucker A, Warner TD, Negishi M, Bishop-Bailey D. Swales KE, et al. Cardiovasc Res. 2012 Mar 15;93(4):674-81. doi: 10.1093/cvr/cvr330. Epub 2011 Dec 13. Cardiovasc Res. 2012. PMID: 22166712 Free PMC article.

6

Activation of the Farnesoid X-receptor in breast cancer cell lines results in cytotoxicity but not increased migration potential.

Alasmael N, Mohan R, Meira LB, Swales KE, Plant NJ. Alasmael N, et al. Cancer Lett. 2016 Jan 28;370(2):250-9. doi: 10.1016/j.canlet.2015.10.031. Epub 2015 Nov 3. Cancer Lett. 2016. PMID: 26545738

7

Use of suppression-PCR subtractive hybridisation to identify genes that demonstrate altered expression in male rat and guinea pig livers following exposure to Wy-14,643, a peroxisome proliferator and non-genotoxic hepatocarcinogen.

Rockett JC, Swales KE, Esdaile DJ, Gibson GG. Rockett JC, et al. Among authors: swales ke. Toxicology. 2000 Apr 3;144(1-3):13-29. doi: 10.1016/s0300-483x(99)00214-0. Toxicology. 2000. PMID: 10781867

8

The potential use of the pregnane X receptor in cardiovascular therapy.

Swales KE, Bishop-Bailey D. Swales KE, et al. Expert Rev Cardiovasc Ther. 2012 Sep;10(9):1079-82. doi: 10.1586/erc.12.103. Expert Rev Cardiovasc Ther. 2012. PMID: 23098141 No abstract available.

9

Nongenomic signaling of the retinoid X receptor through binding and inhibiting Gq in human platelets.

Moraes LA, Swales KE, Wray JA, Damazo A, Gibbins JM, Warner TD, Bishop-Bailey D. Moraes LA, et al. Blood. 2007 May 1;109(9):3741-4. doi: 10.1182/blood-2006-05-022566. Epub 2007 Jan 9. Blood. 2007. PMID: 17213293 Free PMC article.

10

First-in-human study of CH5132799, an oral class I PI3K inhibitor, studying toxicity, pharmacokinetics, and pharmacodynamics, in patients with metastatic cancer.

Blagden S, Omlin A, Josephs D, Stavraka C, Zivi A, Pinato DJ, Anthoney A, Decordova S, Swales K, Riisnaes R, Pope L, Noguchi K, Shiokawa R, Inatani M, Prince J, Jones K, Twelves C, Spicer J, Banerji U. Blagden S, et al. Among authors: swales k. Clin Cancer Res. 2014 Dec 1;20(23):5908-17. doi: 10.1158/1078-0432.CCR-14-1315. Epub 2014 Sep 17. Clin Cancer Res. 2014. PMID: 25231405 Free PMC article. Clinical Trial.

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