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RIG-I Uses an ATPase-Powered Translocation-Throttling Mechanism for Kinetic Proofreading of RNAs and Oligomerization.
Devarkar SC, Schweibenz B, Wang C, Marcotrigiano J, Patel SS. Devarkar SC, et al. Mol Cell. 2018 Oct 18;72(2):355-368.e4. doi: 10.1016/j.molcel.2018.08.021. Epub 2018 Sep 27. Mol Cell. 2018. PMID: 30270105 Free PMC article.
HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity.
Zheng J, Wang C, Chang MR, Devarkar SC, Schweibenz B, Crynen GC, Garcia-Ordonez RD, Pascal BD, Novick SJ, Patel SS, Marcotrigiano J, Griffin PR. Zheng J, et al. Among authors: devarkar sc. Nat Commun. 2018 Dec 18;9(1):5366. doi: 10.1038/s41467-018-07780-z. Nat Commun. 2018. PMID: 30560918 Free PMC article.
APOBEC3A Loop 1 Is a Determinant for Single-Stranded DNA Binding and Deamination.
Ziegler SJ, Hu Y, Devarkar SC, Xiong Y. Ziegler SJ, et al. Among authors: devarkar sc. Biochemistry. 2019 Sep 17;58(37):3838-3847. doi: 10.1021/acs.biochem.9b00394. Epub 2019 Sep 3. Biochemistry. 2019. PMID: 31448897 Free PMC article.
Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.
Devarkar SC, Wang C, Miller MT, Ramanathan A, Jiang F, Khan AG, Patel SS, Marcotrigiano J. Devarkar SC, et al. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):596-601. doi: 10.1073/pnas.1515152113. Epub 2016 Jan 5. Proc Natl Acad Sci U S A. 2016. PMID: 26733676 Free PMC article.
The autoinhibitory CARD2-Hel2i Interface of RIG-I governs RNA selection.
Ramanathan A, Devarkar SC, Jiang F, Miller MT, Khan AG, Marcotrigiano J, Patel SS. Ramanathan A, et al. Among authors: devarkar sc. Nucleic Acids Res. 2016 Jan 29;44(2):896-909. doi: 10.1093/nar/gkv1299. Epub 2015 Nov 26. Nucleic Acids Res. 2016. PMID: 26612866 Free PMC article.
Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA.
Yuan S, Peng L, Park JJ, Hu Y, Devarkar SC, Dong MB, Shen Q, Wu S, Chen S, Lomakin IB, Xiong Y. Yuan S, et al. Among authors: devarkar sc. Mol Cell. 2020 Oct 29:S1097-2765(20)30741-3. doi: 10.1016/j.molcel.2020.10.034. Online ahead of print. Mol Cell. 2020. PMID: 33188728
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