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Replacing the eleven native tryptophans by directed evolution produces an active P-glycoprotein with site-specific, non-conservative substitutions.
Swartz DJ, Singh A, Sok N, Thomas JN, Weber J, Urbatsch IL. Swartz DJ, et al. Sci Rep. 2020 Feb 21;10(1):3224. doi: 10.1038/s41598-020-59802-w. Sci Rep. 2020. PMID: 32081894 Free PMC article.
Substrate-induced conformational changes in the nucleotide-binding domains of lipid bilayer-associated P-glycoprotein during ATP hydrolysis.
Zoghbi ME, Mok L, Swartz DJ, Singh A, Fendley GA, Urbatsch IL, Altenberg GA. Zoghbi ME, et al. Among authors: swartz dj. J Biol Chem. 2017 Dec 15;292(50):20412-20424. doi: 10.1074/jbc.M117.814186. Epub 2017 Oct 9. J Biol Chem. 2017. PMID: 29018094 Free PMC article.
Interactions and cooperativity between P-glycoprotein structural domains determined by thermal unfolding provides insights into its solution structure and function.
Yang Z, Zhou Q, Mok L, Singh A, Swartz DJ, Urbatsch IL, Brouillette CG. Yang Z, et al. Among authors: swartz dj. Biochim Biophys Acta Biomembr. 2017 Jan;1859(1):48-60. doi: 10.1016/j.bbamem.2016.10.009. Epub 2016 Oct 23. Biochim Biophys Acta Biomembr. 2017. PMID: 27783926 Free article.
Directed evolution of P-glycoprotein cysteines reveals site-specific, non-conservative substitutions that preserve multidrug resistance.
Swartz DJ, Mok L, Botta SK, Singh A, Altenberg GA, Urbatsch IL. Swartz DJ, et al. Biosci Rep. 2014 Jun 25;34(3):e00116. doi: 10.1042/BSR20140062. Biosci Rep. 2014. PMID: 24825346 Free PMC article.
Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.
Ward AB, Szewczyk P, Grimard V, Lee CW, Martinez L, Doshi R, Caya A, Villaluz M, Pardon E, Cregger C, Swartz DJ, Falson PG, Urbatsch IL, Govaerts C, Steyaert J, Chang G. Ward AB, et al. Among authors: swartz dj. Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13386-91. doi: 10.1073/pnas.1309275110. Epub 2013 Jul 30. Proc Natl Acad Sci U S A. 2013. PMID: 23901103 Free PMC article.
P-glycoprotein is fully active after multiple tryptophan substitutions.
Swartz DJ, Weber J, Urbatsch IL. Swartz DJ, et al. Biochim Biophys Acta. 2013 Mar;1828(3):1159-68. doi: 10.1016/j.bbamem.2012.12.005. Epub 2012 Dec 19. Biochim Biophys Acta. 2013. PMID: 23261390 Free PMC article.
A gene optimization strategy that enhances production of fully functional P-glycoprotein in Pichia pastoris.
Bai J, Swartz DJ, Protasevich II, Brouillette CG, Harrell PM, Hildebrandt E, Gasser B, Mattanovich D, Ward A, Chang G, Urbatsch IL. Bai J, et al. Among authors: swartz dj. PLoS One. 2011;6(8):e22577. doi: 10.1371/journal.pone.0022577. Epub 2011 Aug 3. PLoS One. 2011. PMID: 21826197 Free PMC article.
Infrared studies of carbon monoxide binding to carbon monoxide dehydrogenase/acetyl-CoA synthase from Moorella thermoacetica.
Chen J, Huang S, Seravalli J, Gutzman H Jr, Swartz DJ, Ragsdale SW, Bagley KA. Chen J, et al. Among authors: swartz dj. Biochemistry. 2003 Dec 23;42(50):14822-30. doi: 10.1021/bi0349470. Biochemistry. 2003. PMID: 14674756
Infrared studies of the CO-inhibited form of the Fe-only hydrogenase from Clostridium pasteurianum I: examination of its light sensitivity at cryogenic temperatures.
Chen Z, Lemon BJ, Huang S, Swartz DJ, Peters JW, Bagley KA. Chen Z, et al. Among authors: swartz dj. Biochemistry. 2002 Feb 12;41(6):2036-43. doi: 10.1021/bi011510o. Biochemistry. 2002. PMID: 11827551
Immunolocalization of tenascin in the chinchilla inner ear.
Swartz DJ, Santi PA. Swartz DJ, et al. Hear Res. 1999 Apr;130(1-2):108-14. doi: 10.1016/s0378-5955(98)00229-9. Hear Res. 1999. PMID: 10320102
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