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Loss of the metalloprotease ADAM9 leads to cone-rod dystrophy in humans and retinal degeneration in mice.
Parry DA, Toomes C, Bida L, Danciger M, Towns KV, McKibbin M, Jacobson SG, Logan CV, Ali M, Bond J, Chance R, Swendeman S, Daniele LL, Springell K, Adams M, Johnson CA, Booth AP, Jafri H, Rashid Y, Banin E, Strom TM, Farber DB, Sharon D, Blobel CP, Pugh EN Jr, Pierce EA, Inglehearn CF. Parry DA, et al. Among authors: swendeman s. Am J Hum Genet. 2009 May;84(5):683-91. doi: 10.1016/j.ajhg.2009.04.005. Epub 2009 Apr 30. Am J Hum Genet. 2009. PMID: 19409519 Free PMC article.
ADAM9 is involved in pathological retinal neovascularization.
Guaiquil V, Swendeman S, Yoshida T, Chavala S, Campochiaro PA, Blobel CP. Guaiquil V, et al. Among authors: swendeman s. Mol Cell Biol. 2009 May;29(10):2694-703. doi: 10.1128/MCB.01460-08. Epub 2009 Mar 9. Mol Cell Biol. 2009. PMID: 19273593 Free PMC article.
Stimulation of platelet-derived growth factor receptor beta (PDGFRbeta) activates ADAM17 and promotes metalloproteinase-dependent cross-talk between the PDGFRbeta and epidermal growth factor receptor (EGFR) signaling pathways.
Mendelson K, Swendeman S, Saftig P, Blobel CP. Mendelson K, et al. Among authors: swendeman s. J Biol Chem. 2010 Aug 6;285(32):25024-32. doi: 10.1074/jbc.M110.102566. Epub 2010 Jun 7. J Biol Chem. 2010. PMID: 20529858 Free PMC article.
ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23.
Weskamp G, Ford JW, Sturgill J, Martin S, Docherty AJ, Swendeman S, Broadway N, Hartmann D, Saftig P, Umland S, Sehara-Fujisawa A, Black RA, Ludwig A, Becherer JD, Conrad DH, Blobel CP. Weskamp G, et al. Among authors: swendeman s. Nat Immunol. 2006 Dec;7(12):1293-8. doi: 10.1038/ni1399. Epub 2006 Oct 29. Nat Immunol. 2006. PMID: 17072319
iRHOM2 is a critical pathogenic mediator of inflammatory arthritis.
Issuree PD, Maretzky T, McIlwain DR, Monette S, Qing X, Lang PA, Swendeman SL, Park-Min KH, Binder N, Kalliolias GD, Yarilina A, Horiuchi K, Ivashkiv LB, Mak TW, Salmon JE, Blobel CP. Issuree PD, et al. Among authors: swendeman sl. J Clin Invest. 2013 Feb;123(2):928-32. doi: 10.1172/JCI66168. Epub 2013 Jan 25. J Clin Invest. 2013. PMID: 23348744 Free PMC article.
40 results