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The Swi5-Sfr1 complex regulates Dmc1- and Rad51-driven DNA strand exchange proceeding through two distinct three-stranded intermediates by different mechanisms.
Ito K, Maki T, Kanamaru S, Takahashi M, Iwasaki H. Ito K, et al. Nucleic Acids Res. 2024 Nov 11;52(20):12517-12533. doi: 10.1093/nar/gkae841. Nucleic Acids Res. 2024. PMID: 39340300 Free PMC article.
In eukaryotes, Dmc1 and Rad51 are key proteins of homologous recombination. The Swi5-Sfr1 complex in fission yeast, a conserved auxiliary factor, stimulates DNA strand exchange driven by both Dmc1 and Rad51. ...Although Swi5-Sfr1 stimulated the …
In eukaryotes, Dmc1 and Rad51 are key proteins of homologous recombination. The Swi5-Sfr1 complex in fission yeast, a c …
Cooperative interactions facilitate stimulation of Rad51 by the Swi5-Sfr1 auxiliary factor complex.
Argunhan B, Sakakura M, Afshar N, Kurihara M, Ito K, Maki T, Kanamaru S, Murayama Y, Tsubouchi H, Takahashi M, Takahashi H, Iwasaki H. Argunhan B, et al. Elife. 2020 Mar 24;9:e52566. doi: 10.7554/eLife.52566. Elife. 2020. PMID: 32204793 Free PMC article.
The experiments showed that both modules of Swi5-Sfr1 were important for Rad51 to drive homologous recombination. Swi5-Sfr1 complexes carrying mutations in the region of Sfr1N that binds to Rad51 were unable to activate Rad51 in a test tube. ... …
The experiments showed that both modules of Swi5-Sfr1 were important for Rad51 to drive homologous recombination. Swi5- …
Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair through homologous recombination.
Akamatsu Y, Jasin M. Akamatsu Y, et al. PLoS Genet. 2010 Oct 14;6(10):e1001160. doi: 10.1371/journal.pgen.1001160. PLoS Genet. 2010. PMID: 20976249 Free PMC article.
In fission yeast, the Swi5-Sfr1 complex plays an important role in homologous recombination (HR), a pathway crucial for the maintenance of genomic integrity. ...By generating Swi5(-/-) and Sfr1(-/-) embryonic stem cell lines, we found that both proteins are m …
In fission yeast, the Swi5-Sfr1 complex plays an important role in homologous recombination (HR), a pathway crucial for …
Rad51 presynaptic filament stabilization function of the mouse Swi5-Sfr1 heterodimeric complex.
Tsai SP, Su GC, Lin SW, Chung CI, Xue X, Dunlop MH, Akamatsu Y, Jasin M, Sung P, Chi P. Tsai SP, et al. Nucleic Acids Res. 2012 Aug;40(14):6558-69. doi: 10.1093/nar/gks305. Epub 2012 Apr 9. Nucleic Acids Res. 2012. PMID: 22492707 Free PMC article.
Recent studies have found that the human and mouse Swi5 and Sfr1 proteins form a complex that influences Rad51-mediated HR in cells. Here, we provide biophysical evidence that the mouse Swi5-Sfr1 complex has a 1:1 stoichiometry. Importantly, the Swi …
Recent studies have found that the human and mouse Swi5 and Sfr1 proteins form a complex that influences Rad51-mediated HR in cells. …
Expression, purification and crystallization of Swi5 and the Swi5-Sfr1 complex from fission yeast.
Kuwabara N, Hashimoto H, Yamada N, Unzai S, Ikeguchi M, Sato M, Murayama Y, Iwasaki H, Shimizu T. Kuwabara N, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Sep 1;66(Pt 9):1124-6. doi: 10.1107/S1744309110032239. Epub 2010 Aug 31. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010. PMID: 20823543 Free PMC article.
Swi5 and Sfr1 have been identified as mediators in fission yeast and these proteins form a complex that stimulates strand exchange. Here, the expression, purification and crystallization of Swi5 and its complex with an N-terminally truncated form of Sfr1 (DeltaN180S …
Swi5 and Sfr1 have been identified as mediators in fission yeast and these proteins form a complex that stimulates strand exchange. H …
The Swi5-Sfr1 complex stimulates Rhp51/Rad51- and Dmc1-mediated DNA strand exchange in vitro.
Haruta N, Kurokawa Y, Murayama Y, Akamatsu Y, Unzai S, Tsutsui Y, Iwasaki H. Haruta N, et al. Nat Struct Mol Biol. 2006 Sep;13(9):823-30. doi: 10.1038/nsmb1136. Epub 2006 Aug 20. Nat Struct Mol Biol. 2006. PMID: 16921379
The Swi5-Sfr1 complex overcomes, at least partly, the inhibitory effect of RPA, representing a novel class of mediator. Notably, the Swi5-Sfr1 complex preferentially stimulates the ssDNA-dependent ATPase activity of Rhp51, and it increase …
The Swi5-Sfr1 complex overcomes, at least partly, the inhibitory effect of RPA, representing a novel class of mediator. …
Fission yeast Swi5-Sfr1 protein complex, an activator of Rad51 recombinase, forms an extremely elongated dogleg-shaped structure.
Kokabu Y, Murayama Y, Kuwabara N, Oroguchi T, Hashimoto H, Tsutsui Y, Nozaki N, Akashi S, Unzai S, Shimizu T, Iwasaki H, Sato M, Ikeguchi M. Kokabu Y, et al. J Biol Chem. 2011 Dec 16;286(50):43569-76. doi: 10.1074/jbc.M111.303339. Epub 2011 Oct 27. J Biol Chem. 2011. PMID: 22033972 Free PMC article.
Furthermore, we determined a rough topology of the complex by comparing the small-angle x-ray scattering-based structures of the Swi5-Sfr1 complex and four Swi5-Sfr1-Fab complexes, in which the Fab fragments of monoclonal antibodie …
Furthermore, we determined a rough topology of the complex by comparing the small-angle x-ray scattering-based structures of the S …
Mapping and Analysis of Swi5 and Sfr1 Phosphorylation Sites.
Sevcovicova A, Plava J, Gazdarica M, Szabova E, Huraiova B, Gaplovska-Kysela K, Cipakova I, Cipak L, Gregan J. Sevcovicova A, et al. Genes (Basel). 2021 Jun 30;12(7):1014. doi: 10.3390/genes12071014. Genes (Basel). 2021. PMID: 34208949 Free PMC article.
The evolutionarily conserved Swi5-Sfr1 complex plays an important role in homologous recombination, a process crucial for the maintenance of genomic integrity. Here, we purified Schizosaccharomyces pombe Swi5-Sfr1 complex from meiotic cel …
The evolutionarily conserved Swi5-Sfr1 complex plays an important role in homologous recombination, a process crucial f …
Enhancement of ADP release from the RAD51 presynaptic filament by the SWI5-SFR1 complex.
Su GC, Chung CI, Liao CY, Lin SW, Tsai CT, Huang T, Li HW, Chi P. Su GC, et al. Nucleic Acids Res. 2014 Jan;42(1):349-58. doi: 10.1093/nar/gkt879. Epub 2013 Sep 27. Nucleic Acids Res. 2014. PMID: 24078249 Free PMC article.
Here we characterize the RAD51 presynaptic filament stabilization function of the SWI5-SFR1 complex using optical tweezers. Biochemical experiments reveal that SWI5-SFR1 enhances ATP hydrolysis by single-stranded DNA-bound RAD51. Importantly, we …
Here we characterize the RAD51 presynaptic filament stabilization function of the SWI5-SFR1 complex using optical tweez …
Mechanistic insights into the activation of Rad51-mediated strand exchange from the structure of a recombination activator, the Swi5-Sfr1 complex.
Kuwabara N, Murayama Y, Hashimoto H, Kokabu Y, Ikeguchi M, Sato M, Mayanagi K, Tsutsui Y, Iwasaki H, Shimizu T. Kuwabara N, et al. Structure. 2012 Mar 7;20(3):440-9. doi: 10.1016/j.str.2012.01.005. Structure. 2012. PMID: 22405003 Free article.
Rad51 forms a helical filament on single-stranded DNA and promotes strand exchange between two homologous DNA molecules during homologous recombination. The Swi5-Sfr1 complex interacts directly with Rad51 and stimulates strand exchange. Here we describe struc …
Rad51 forms a helical filament on single-stranded DNA and promotes strand exchange between two homologous DNA molecules during homologous re …
31 results