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Stereoisomers of ketoconazole: preparation and biological activity.
Rotstein DM, Kertesz DJ, Walker KA, Swinney DC. Rotstein DM, et al. J Med Chem. 1992 Jul 24;35(15):2818-25. doi: 10.1021/jm00093a015. J Med Chem. 1992. PMID: 1495014
Androgen formation by cytochrome P450 CYP17. Solvent isotope effect and pL studies suggest a role for protons in the regulation of oxene versus peroxide chemistry.
Swinney DC, Mak AY. Swinney DC, et al. Biochemistry. 1994 Mar 1;33(8):2185-90. doi: 10.1021/bi00174a027. Biochemistry. 1994. PMID: 8117675
., & Swinney, D. C. (1992) J. Am. Chem. Soc. 114, 8309]. Accordingly, CYP17 is proposed to catalyze oxidations via both oxene and peroxide chemistry. ...
., & Swinney, D. C. (1992) J. Am. Chem. Soc. 114, 8309]. Accordingly, CYP17 is proposed to catalyze oxidations via both oxene and …
Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering.
Walker KA, Kertesz DJ, Rotstein DM, Swinney DC, Berry PW, So OY, Webb AS, Watson DM, Mak AY, Burton PM, et al. Walker KA, et al. J Med Chem. 1993 Jul 23;36(15):2235-7. doi: 10.1021/jm00067a022. J Med Chem. 1993. PMID: 8340925 No abstract available.
Pharmacology of a Ca(2+)-influx pathway activated by emptying the intracellular Ca2+ stores in HL-60 cells: evidence that a cytochrome P-450 is not involved.
Koch BD, Faurot GF, Kopanitsa MV, Swinney DC. Koch BD, et al. Biochem J. 1994 Aug 15;302 ( Pt 1)(Pt 1):187-90. doi: 10.1042/bj3020187. Biochem J. 1994. PMID: 8068004 Free PMC article.
Azalanstat (RS-21607), a lanosterol 14 alpha-demethylase inhibitor with cholesterol-lowering activity.
Burton PM, Swinney DC, Heller R, Dunlap B, Chiou M, Malonzo E, Haller J, Walker KA, Salari A, Murakami S, et al. Burton PM, et al. Biochem Pharmacol. 1995 Aug 8;50(4):529-44. doi: 10.1016/0006-2952(95)00152-p. Biochem Pharmacol. 1995. PMID: 7646560
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