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61 results
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The role of binding kinetics in therapeutically useful drug action.
Swinney DC. Swinney DC. Curr Opin Drug Discov Devel. 2009 Jan;12(1):31-9. Curr Opin Drug Discov Devel. 2009. PMID: 19152211
Phenotypic vs. target-based drug discovery for first-in-class medicines.
Swinney DC. Swinney DC. Clin Pharmacol Ther. 2013 Apr;93(4):299-301. doi: 10.1038/clpt.2012.236. Clin Pharmacol Ther. 2013. PMID: 23511784
Challenges and Hurdles to Business as Usual in Drug Development for Treatment of Rare Diseases.
Swinney DC. Swinney DC. Clin Pharmacol Ther. 2016 Oct;100(4):339-41. doi: 10.1002/cpt.422. Epub 2016 Aug 16. Clin Pharmacol Ther. 2016. PMID: 27393380
Enzyme Activity Assays for Protein Kinases: Strategies to Identify Active Substrates.
Haubrich BA, Swinney DC. Haubrich BA, et al. Among authors: swinney dc. Curr Drug Discov Technol. 2016;13(1):2-15. doi: 10.2174/1570163813666160115125930. Curr Drug Discov Technol. 2016. PMID: 26768716 Free PMC article. Review.
The Role of Binding Kinetics in GPCR Drug Discovery.
Swinney DC, Haubrich BA, Van Liefde I, Vauquelin G. Swinney DC, et al. Curr Top Med Chem. 2015;15(24):2504-22. doi: 10.2174/1568026615666150701113054. Curr Top Med Chem. 2015. PMID: 26126905 Review.
Radioligand binding to intact cells as a tool for extended drug screening in a representative physiological context.
Vauquelin G, Van Liefde I, Swinney DC. Vauquelin G, et al. Among authors: swinney dc. Drug Discov Today Technol. 2015 Oct;17:28-34. doi: 10.1016/j.ddtec.2015.09.001. Epub 2015 Oct 23. Drug Discov Today Technol. 2015. PMID: 26724334 Review.
A study of the molecular mechanism of binding kinetics and long residence times of human CCR5 receptor small molecule allosteric ligands.
Swinney DC, Beavis P, Chuang KT, Zheng Y, Lee I, Gee P, Deval J, Rotstein DM, Dioszegi M, Ravendran P, Zhang J, Sankuratri S, Kondru R, Vauquelin G. Swinney DC, et al. Br J Pharmacol. 2014 Jul;171(14):3364-75. doi: 10.1111/bph.12683. Br J Pharmacol. 2014. PMID: 24628038 Free PMC article.
Targeting protein ubiquitination for drug discovery. What is in the drug discovery toolbox?
Swinney DC. Swinney DC. Drug Discov Today. 2001 Mar 1;6(5):244-250. doi: 10.1016/s1359-6446(00)01650-0. Drug Discov Today. 2001. PMID: 11182597
Biochemical mechanisms of New Molecular Entities (NMEs) approved by United States FDA during 2001-2004: mechanisms leading to optimal efficacy and safety.
Swinney DC. Swinney DC. Curr Top Med Chem. 2006;6(5):461-78. doi: 10.2174/156802606776743093. Curr Top Med Chem. 2006. PMID: 16719803 Review.
How were new medicines discovered?
Swinney DC, Anthony J. Swinney DC, et al. Nat Rev Drug Discov. 2011 Jun 24;10(7):507-19. doi: 10.1038/nrd3480. Nat Rev Drug Discov. 2011. PMID: 21701501 Review.
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